selected publications
- Inhibition of Bruton's tyrosine kinase with PD-1 blockade modulates T cell activation in solid tumors. JCI insight. 2024 Academic Article GET IT
- The interplay of mutagenesis and ecDNA shapes urothelial cancer evolution. Nature. 2024 Academic Article GET IT
- The power and perils of large language models in haematology. British journal of haematology. 2024 Review GET IT
- Detection of rare and novel gene fusions in patients with diffuse glioma: An institutional retrospective study. Journal of neuropathology and experimental neurology. 2024 Academic Article GET IT
- Deficiency of metabolic regulator PKM2 activates the pentose phosphate pathway and generates TCF1+ progenitor CD8+ T cells to improve immunotherapy. Nature immunology. 2024 Academic Article GET IT
- Automatic ploidy prediction and quality assessment of human blastocysts using time-lapse imaging. Nature communications. 2024 Academic Article GET IT
- HLA-E and NKG2A Mediate Resistance to M. bovis BCG Immunotherapy in Non-Muscle-Invasive Bladder Cancer. 2024 GET IT
- Mechanism of neurodegeneration mediated by clonal inflammatory microglia. 2024 GET IT
- Tumor evolution analysis uncovered immune-escape related mutations in relapse of diffuse large B-cell lymphoma. Leukemia. 2024 Letter GET IT
- Integrative Transcriptomic and Single-Cell Protein Characterization of Colorectal Carcinoma Delineates Distinct Tumor Immune Microenvironments Associated with Overall Survival. 2024 GET IT
- The Orphan G Protein-Coupled Receptor GPR52 is a Novel Regulator of Breast Cancer Multicellular Organization. 2024 GET IT
-
Multi-parametric atlas of the pre-metastatic liver for prediction of metastatic outcome in early-stage pancreatic cancer.
Nature medicine.
2024
Academic Article
GET IT
Times cited: 4 - Transferrin receptor-based circulating tumor cell enrichment provides a snapshot of the molecular landscape of solid tumors and correlates with clinical outcomes. 2024 GET IT
- ACK1 and BRK non-receptor tyrosine kinase deficiencies are associated with familial systemic lupus and involved in efferocytosis. 2024 GET IT
- Optimization of Fluorescence In Situ Hybridization Protocols in the Era of Precision Medicine. Current protocols. 2024 Academic Article GET IT
- Developing a predictive model for metastatic potential in pancreatic neuroendocrine tumor. The Journal of clinical endocrinology and metabolism. 2024 Academic Article GET IT
- The intrinsic substrate specificity of the human tyrosine kinome. Nature. 2024 Academic Article GET IT
- Benchmarking multi-ancestry prostate cancer polygenic risk scores in a real-world cohort. PLoS computational biology. 2024 Academic Article GET IT
- How Artificial Intelligence Unravels the Complex Web of Cancer Drug Response. Cancer research. 2024 Academic Article GET IT
- MGMT ProFWise: Unlocking a New Application for Combined Feature Selection and the Rank-Based Weighting Method to Link MGMT Methylation Status to Serum Protein Expression in Patients with Glioblastoma. International journal of molecular sciences. 2024 Academic Article GET IT
- The evolution of metastatic upper tract urothelial carcinoma through genomic-transcriptomic and single-cell protein markers analysis. Nature communications. 2024 Academic Article GET IT
- Rewiring Endothelial Sphingolipid Metabolism to Favor S1P Over Ceramide Protects From Coronary Atherosclerosis. Circulation research. 2024 Academic Article GET IT
- Tumor-Associated Lymphocytes and Breast Cancer Survival in Black and White Women. JAMA surgery. 2024 Academic Article GET IT
- Voice as an AI Biomarker of Health-Introducing Audiomics. JAMA otolaryngology-- head & neck surgery. 2024 Academic Article GET IT
- Whole-Genome Sequencing Analysis of Male Breast Cancer Unveils Novel Structural Events and Potential Therapeutic Targets. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 2024 Academic Article GET IT
- Cysteine induces mitochondrial reductive stress in glioblastoma through hydrogen peroxide production. Proceedings of the National Academy of Sciences of the United States of America. 2024 Academic Article GET IT
- A signature of enhanced proliferation associated with response and survival to anti-PD-L1 therapy in early-stage non-small cell lung cancer. Cell reports. Medicine. 2024 Academic Article GET IT
- The nuclear factor ID3 endows macrophages with a potent anti-tumour activity. Nature. 2024 Academic Article GET IT
- A microglia clonal inflammatory disorder in Alzheimer's Disease. 2024 GET IT
- Deciphering the origin and therapeutic targets of cancer of unknown primary: a case report that illustrates the power of integrative whole-exome and transcriptome sequencing analysis. 2024 GET IT
- Non-invasive detection of neuroendocrine prostate cancer through targeted cell-free DNA methylation. Cancer discovery. 2024 Academic Article GET IT
- Patient-derived tumor organoids with p53 mutations, and not wild-type p53, are sensitive to synergistic combination PARP inhibitor treatment. Cancer letters. 2024 Academic Article GET IT
- Author Correction: Neoadjuvant durvalumab plus radiation versus durvalumab alone in stages I-III non-small cell lung cancer: survival outcomes and molecular correlates of a randomized phase II trial. 2024 GET IT
- Neoadjuvant durvalumab plus radiation versus durvalumab alone in stages I-III non-small cell lung cancer: survival outcomes and molecular correlates of a randomized phase II trial. Nature communications. 2023 Academic Article GET IT
- A pancreatic cancer organoid platform identifies an inhibitor specific to mutant KRAS. Cell stem cell. 2023 Academic Article GET IT
- NIPBL::NACC1 Fusion Hepatic Carcinoma. The American journal of surgical pathology. 2023 Academic Article GET IT
- A reversible epigenetic memory of inflammatory injury controls lineage plasticity and tumor initiation in the mouse pancreas. Developmental cell. 2023 Academic Article GET IT
- Transcriptomic signatures of chronic active antibody-mediated rejection deciphered by RNA sequencing of human kidney allografts. Kidney international. 2023 Academic Article GET IT
- Breast adipose tissue-derived extracellular vesicles from obese women alter tumor cell metabolism. EMBO reports. 2023 Academic Article GET IT
- Author Correction: Evolution of structural rearrangements in prostate cancer intracranial metastases. 2023 GET IT
- The Landscape of US and Global Rare Tumor Research Programs: A Systematic Review. The oncologist. 2023 Academic Article GET IT
- FORMATION OF MALIGNANT, METASTATIC SMALL CELL LUNG CANCERS THROUGH OVERPRODUCTION OF cMYC PROTEIN IN TP53 AND RB1 DEPLETED PULMONARY NEUROENDOCRINE CELLS DERIVED FROM HUMAN EMBRYONIC STEM CELLS. 2023 GET IT
- Using Machine Learning Methods to Assess the Risk of Alcohol Misuse in Older Adults. 2023 GET IT
- TIMP1 is an early biomarker for detection and prognosis of lung cancer. Clinical and translational medicine. 2023 Academic Article GET IT
- Deficiency of metabolic regulator PKM2 activates the pentose phosphate pathway and generates TCF1+ progenitor CD8+ T cells to improve checkpoint blockade. 2023 GET IT
- Advanced age in humans and mouse models of glioblastoma show decreased survival from extratumoral influence. Clinical cancer research : an official journal of the American Association for Cancer Research. 2023 Academic Article GET IT
- Evolution of structural rearrangements in prostate cancer intracranial metastases. NPJ precision oncology. 2023 Academic Article GET IT
- A deep learning pipeline for automated classification of vocal fold polyps in flexible laryngoscopy. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. 2023 Academic Article GET IT
- Mapping human natural killer cell development in pediatric tonsil by imaging mass cytometry and high-resolution microscopy. 2023 GET IT
- Automatic Ploidy Prediction and Quality Assessment of Human Blastocyst Using Time-Lapse Imaging. 2023 GET IT
- The importance of escalating molecular diagnostics in patients with low-grade pediatric brain cancer. Cold Spring Harbor molecular case studies. 2023 Academic Article GET IT
-
Epigenetic memory of coronavirus infection in innate immune cells and their progenitors.
Cell.
2023
Academic Article
GET IT
Times cited: 2 - Long-molecule scars of backup DNA repair in BRCA1- and BRCA2-deficient cancers. Nature. 2023 Academic Article GET IT
- SPRY4-dependent ERK negative feedback demarcates functional adult stem cells in the male mouse germline. Biology of reproduction. 2023 Academic Article GET IT
- The Relationship of Duffy Gene Polymorphism, High Sensitivity C-Reactive Protein, and Long-term Outcomes. 2023 GET IT
- Bone-matrix mineralization dampens integrin-mediated mechanosignalling and metastatic progression in breast cancer. Nature biomedical engineering. 2023 Academic Article GET IT
- The Identification of CELSR3 and Other Potential Cell Surface Targets in Neuroendocrine Prostate Cancer. Cancer research communications. 2023 Academic Article GET IT
- Insulin feedback is a targetable resistance mechanism of PI3K inhibition in glioblastoma. Neuro-oncology. 2023 Academic Article GET IT
- Patient-derived tumor organoids with p53 mutations, and not wild-type p53, are sensitive to synergistic combination PARP inhibitor treatment. 2023 GET IT
- PRMT5 Inhibition Drives Therapeutic Vulnerability to Combination Treatment with BCL-2 Inhibition in Mantle Cell Lymphoma. Blood advances. 2023 Academic Article GET IT
- How I read an article that uses machine learning methods. Blood advances. 2023 Academic Article GET IT
- PRMT5 supports multiple oncogenic pathways in mantle cell lymphoma. Blood. 2023 Academic Article GET IT
- The Immunogenomic Landscape of Neuroendocrine Prostate Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2023 Academic Article GET IT
- Genetic Risk Factors for End-Stage Hip Osteoarthritis Treated with Total Hip Arthroplasty: A Genome-Wide Association Study. The Journal of arthroplasty. 2023 Academic Article GET IT
-
Multicenter phase 2 study of oral azacitidine (CC-486) plus CHOP as initial treatment for PTCL.
Blood.
2023
Academic Article
GET IT
Times cited: 26 -
A Unique Cellular Organization of Human Distal Airways and Its Disarray in Chronic Obstructive Pulmonary Disease.
American journal of respiratory and critical care medicine.
2023
Academic Article
GET IT
Times cited: 25 - Multi-omic molecular profiling and network biology for precision anaesthesiology: a narrative review. British journal of anaesthesia. 2023 Review GET IT
- Soluble adenylyl cyclase contributes to imiquimod-mediated inflammation and is a potential therapeutic target in psoriasis. Experimental dermatology. 2023 Academic Article GET IT
-
Landscape of prostate-specific membrane antigen heterogeneity and regulation in AR-positive and AR-negative metastatic prostate cancer.
Nature cancer.
2023
Academic Article
GET IT
Times cited: 43 - Metasurface-enhanced infrared spectroscopy in multiwell format for real-time assaying of live cells. Lab on a chip. 2023 Academic Article GET IT
-
Combinatorial treatment rescues tumour-microenvironment-mediated attenuation of MALT1 inhibitors in B-cell lymphomas.
Nature materials.
2023
Academic Article
GET IT
Times cited: 19 - Identification of Novel Genetic Markers for the Risk of Spinal Pathologies: A Genome-Wide Association Study of 2 Biobanks. The Journal of bone and joint surgery. American volume. 2023 Academic Article GET IT
- Single-cell RNA sequencing reveals immunosuppressive myeloid cell diversity during malignant progression in a murine model of glioma. Cell reports. 2023 Academic Article GET IT
-
Obesity promotes breast epithelium DNA damage in women carrying a germline mutation in BRCA1 or BRCA2.
Science translational medicine.
2023
Academic Article
GET IT
Times cited: 1 - Molecular evolution of classic Hodgkin lymphoma revealed through whole genome sequencing of Hodgkin and Reed Sternberg cells. Blood cancer discovery. 2023 Academic Article GET IT
- Wearable sensor-based performance status assessment in cancer: A pilot multicenter study from the Alliance for Clinical Trials in Oncology (A19_Pilot2). PLOS digital health. 2023 Academic Article GET IT
- BTG1 mutation yields supercompetitive B cells primed for malignant transformation. Science (New York, N.Y.). 2023 Academic Article GET IT
- An atlas of substrate specificities for the human serine/threonine kinome. Nature. 2023 Academic Article GET IT
- Population-Level Prevalence of Rare Variants Associated With Atrial Fibrillation and its Impact on Patient Outcomes. JACC. Clinical electrophysiology. 2023 Academic Article GET IT
-
Tumor-intrinsic IRE1α signaling controls protective immunity in lung cancer.
Nature communications.
2023
Academic Article
GET IT
Times cited: 16 - A non-invasive artificial intelligence approach for the prediction of human blastocyst ploidy: a retrospective model development and validation study. The Lancet. Digital health. 2023 Academic Article GET IT
- Whole-genome characterization of myoepithelial carcinomas of the soft tissue. Cold Spring Harbor molecular case studies. 2022 Academic Article GET IT
-
A FOXO1-dependent transcription network is a targetable vulnerability of mantle cell lymphomas.
The Journal of clinical investigation.
2022
Academic Article
GET IT
Times cited: 7 - Application of Deep Learning on Single-cell RNA Sequencing Data Analysis: A Review. Genomics, proteomics & bioinformatics. 2022 Review GET IT
- Spatial omics technologies at multimodal and single cell/subcellular level. Genome biology. 2022 Review GET IT
-
Metastatic pancreatic neuroendocrine tumors feature elevated T cell infiltration.
JCI insight.
2022
Academic Article
GET IT
Times cited: 7 - The cytidine deaminase APOBEC3G contributes to cancer mutagenesis and clonal evolution in bladder cancer. Cancer research. 2022 Academic Article GET IT
- Implementation of Whole-Genome and Transcriptome Sequencing Into Clinical Cancer Care. JCO precision oncology. 2022 Review GET IT
- Genome-Wide Association Study of Adhesive Capsulitis Suggests Significant Genetic Risk Factors. The Journal of bone and joint surgery. American volume. 2022 Academic Article GET IT
- Unsupervised discovery of tissue architecture in multiplexed imaging. Nature methods. 2022 Academic Article GET IT
- Host protein kinases required for SARS-CoV-2 nucleocapsid phosphorylation and viral replication. Science signaling. 2022 Academic Article GET IT
- Predicting inpatient mortality in patients with inflammatory bowel disease: A machine learning approach. Journal of gastroenterology and hepatology. 2022 Academic Article GET IT
- A nuclear cAMP microdomain suppresses tumor growth by Hippo pathway inactivation. Cell reports. 2022 Academic Article GET IT
- Tumor Infiltrating Myeloid Cells Confer de novo Resistance to PD-L1 Blockade through EMT-stromal and Tgf-beta Dependent Mechanisms. Molecular cancer therapeutics. 2022 Academic Article GET IT
- African Ancestry Associated Gene Expression Profiles in Triple Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African Descent. Cancer discovery. 2022 Academic Article GET IT
- Sensing of SARS-CoV-2 by pDCs and their subsequent production of IFN-I contribute to macrophage-induced cytokine storm during COVID-19. Science immunology. 2022 Academic Article GET IT
- Gain of Chromosome 1q Perturbs a Competitive Endogenous RNA Network to Promote Melanoma Metastasis. Cancer research. 2022 Academic Article GET IT
- A Knock-in Mouse Model of Thymoma with the GTF2I L424H Mutation. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2022 Academic Article GET IT
- GA4GH Phenopackets: A Practical Introduction. Advanced genetics (Hoboken, N.J.). 2022 Academic Article GET IT
- Characterization of Genetic Risk of End-Stage Knee Osteoarthritis Treated with Total Knee Arthroplasty: A Genome-Wide Association Study. The Journal of bone and joint surgery. American volume. 2022 Academic Article GET IT
- Endothelial-leukemia interactions remodel drug responses uncovering T-ALL vulnerabilities. Blood. 2022 Academic Article GET IT
- GLI1-Rearranged Enteric Tumor: Expanding the Spectrum of Gastrointestinal Neoplasms with GLI1 gene fusions. The American journal of surgical pathology. 2022 Academic Article GET IT
- Next generation patient derived tumor organoids. Translational research : the journal of laboratory and clinical medicine. 2022 Review GET IT
- Nicotinamide drives T cell activation in the mammary tumor microenvironment. Journal of translational medicine. 2022 Letter GET IT
-
The GA4GH Phenopacket schema defines a computable representation of clinical data.
Nature biotechnology.
2022
Letter
GET IT
Times cited: 41 - Weakly-supervised tumor purity prediction from frozen H&E stained slides. EBioMedicine. 2022 Academic Article GET IT
- Tumor-induced double positive T cells display distinct lineage commitment mechanisms and functions. The Journal of experimental medicine. 2022 Academic Article GET IT
- Alterations in transcriptional networks in cancer: the role of noncoding somatic driver mutations. Current opinion in genetics & development. 2022 Review GET IT
- The lactate-NAD+ axis activates cancer-associated fibroblasts by downregulating p62. Cell reports. 2022 Academic Article GET IT
- An activation to memory differentiation trajectory of tumor-infiltrating lymphocytes informs metastatic melanoma outcomes. Cancer cell. 2022 Academic Article GET IT
-
Inhibition of FGF receptor blocks adaptive resistance to RET inhibition in CCDC6-RET-rearranged thyroid cancer.
The Journal of experimental medicine.
2022
Academic Article
GET IT
Times cited: 9 - Inflammatory Responses in the Placenta upon SARS-CoV-2 Infection Late in Pregnancy. iScience. 2022 Academic Article GET IT
- Global evolution of the tumor microenvironment associated with progression from preinvasive invasive to invasive human lung adenocarcinoma. Cell reports. 2022 Academic Article GET IT
- Molecular and Pharmacological Bladder Cancer Therapy Screening: Discovery of Clofarabine as a Highly Active Compound. European urology. 2022 Academic Article GET IT
- Utility of multimodality molecular profiling for pediatric patients with central nervous system tumors. Neuro-oncology advances. 2022 Academic Article GET IT
-
Detecting Neuroendocrine Prostate Cancer Through Tissue-Informed Cell-Free DNA Methylation Analysis.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2022
Academic Article
GET IT
Times cited: 35 -
RET Fusion-Positive Papillary Thyroid Cancers are Associated with a More Aggressive Phenotype.
Annals of surgical oncology.
2022
Academic Article
GET IT
Times cited: 7 - The genomic landscape of metastatic clear cell renal cell carcinoma after systemic therapy. Molecular oncology. 2022 Academic Article GET IT
- Histone 3 Methyltransferases Alter Melanoma Initiation and Progression Through Discrete Mechanisms. Frontiers in cell and developmental biology. 2022 Academic Article GET IT
- Automatic classification of informative laryngoscopic images using deep learning. Laryngoscope investigative otolaryngology. 2022 Academic Article GET IT
- Simple Linear Cancer Risk Prediction Models With Novel Features Outperform Complex Approaches. JCO clinical cancer informatics. 2022 Academic Article GET IT
-
System-wide transcriptome damage and tissue identity loss in COVID-19 patients.
Cell reports. Medicine.
2022
Academic Article
GET IT
Times cited: 25 - Collision tumors revealed by prospectively assessing subtype-defining molecular alterations in 904 individual prostate cancer foci. JCI insight. 2022 Academic Article GET IT
- Serial ctDNA analysis predicts clinical progression in patients with advanced urothelial carcinoma. British journal of cancer. 2022 Academic Article GET IT
- Metabolic and Immune Markers for Precise Monitoring of COVID-19 Severity and Treatment. Frontiers in immunology. 2022 Academic Article GET IT
- GCN2 kinase activation by ATP-competitive kinase inhibitors. Nature chemical biology. 2021 Academic Article GET IT
- Systems biology analysis of human genomes points to key pathways conferring spina bifida risk. Proceedings of the National Academy of Sciences of the United States of America. 2021 Academic Article GET IT
- Pan-cancer analysis reveals molecular patterns associated with age. Cell reports. 2021 Academic Article GET IT
- Stage-specific regulation of DNA methylation by TET enzymes during human cardiac differentiation. Cell reports. 2021 Academic Article GET IT
- Prediction of primary venous thromboembolism based on clinical and genetic factors within the U.K. Biobank. Scientific reports. 2021 Academic Article GET IT
- Allele-specific genomic data elucidate the role of somatic gain and copy-number neutral loss of heterozygosity in cancer. Cell systems. 2021 Academic Article GET IT
- Extracellular Matrix in Synthetic Hydrogel-based Prostate Cancer Organoids Regulate Therapeutic Response to EZH2 and DRD2 inhibitors. Advanced materials (Deerfield Beach, Fla.). 2021 Academic Article GET IT
- CLIP-170S is a microtubule +TIP variant that confers resistance to taxanes by impairing drug-target engagement. Developmental cell. 2021 Academic Article GET IT
- RNA-Sequencing-Based Transcriptomic Score with Prognostic and Theranostic Values in Multiple Myeloma. Journal of personalized medicine. 2021 Academic Article GET IT
- OCT2 pre-positioning facilitates cell fate transition and chromatin architecture changes in humoral immunity. Nature immunology. 2021 Academic Article GET IT
- Cohesin Core Complex Gene Dosage Contributes to Germinal Center Derived Lymphoma Phenotypes and Outcomes. Frontiers in immunology. 2021 Academic Article GET IT
- The NF-κB transcriptional footprint is essential for SARS-CoV-2 replication. Journal of virology. 2021 Academic Article GET IT
- Multi-platform profiling characterizes molecular subgroups and resistance networks in chronic lymphocytic leukemia. Nature communications. 2021 Academic Article GET IT
-
Reshaping of the androgen-driven chromatin landscape in normal prostate cells by early cancer drivers and effect on therapeutic sensitivity.
Cell reports.
2021
Academic Article
GET IT
Times cited: 1 - Molecular Evaluation of Low-grade Low-stage Endometrial Cancer With and Without Recurrence. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists. 2021 Academic Article GET IT
- Functional comparison of exome capture-based methods for transcriptomic profiling of formalin-fixed paraffin-embedded tumors. NPJ genomic medicine. 2021 Academic Article GET IT
- A polygenic-score-based approach for identification of gene-drug interactions stratifying breast cancer risk. American journal of human genetics. 2021 Academic Article GET IT
- Blood Biomarkers Reflect the Effects of Obesity and Inflammation on the Human Breast Transcriptome. Carcinogenesis. 2021 Academic Article GET IT
- Validation of a Circulating Tumor DNA-Based Next-Generation Sequencing Assay in a Cohort of Patients with Solid tumors: A Proposed Solution for Decentralized Plasma Testing. The oncologist. 2021 Academic Article GET IT
-
Diet-regulated production of PDGFcc by macrophages controls energy storage.
Science (New York, N.Y.).
2021
Academic Article
GET IT
Times cited: 2 - Clinical utility of whole-genome sequencing in precision oncology. Seminars in cancer biology. 2021 Information Resource GET IT
- Characterization of GECPAR, a noncoding RNA that regulates the transcriptional program of diffuse large B cell lymphoma. Haematologica. 2021 Academic Article GET IT
- Analytical demands to use whole-genome sequencing in precision oncology. Seminars in cancer biology. 2021 Information Resource GET IT
- Temporal evolution of cellular heterogeneity during the progression to advanced AR-negative prostate cancer. Nature communications. 2021 Academic Article GET IT
-
Targeting the epichaperome as an effective precision medicine approach in a novel PML-SYK fusion acute myeloid leukemia.
NPJ precision oncology.
2021
Academic Article
GET IT
Times cited: 21 -
Neoadjuvant durvalumab with or without stereotactic body radiotherapy in patients with early-stage non-small-cell lung cancer: a single-centre, randomised phase 2 trial.
The Lancet. Oncology.
2021
Academic Article
GET IT
Times cited: 125 - Incorporating cytologic adequacy assessment into precision oncology workflow using telepathology: An institutional experience. Cancer cytopathology. 2021 Academic Article GET IT
-
A molecular single-cell lung atlas of lethal COVID-19.
Nature.
2021
Academic Article
GET IT
Times cited: 10 - Artificial intelligence in oncology: From bench to clinic. Seminars in cancer biology. 2021 Information Resource GET IT
-
QSER1 protects DNA methylation valleys from de novo methylation.
Science (New York, N.Y.).
2021
Academic Article
GET IT
Times cited: 61 - RNA-sequencing data-driven dissection of human plasma cell differentiation reveals new potential transcription regulators. Leukemia. 2021 Academic Article GET IT
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Deep learning predicts chromosomal instability from histopathology images.
iScience.
2021
Academic Article
GET IT
Times cited: 21 -
Artificial Intelligence in Cancer Research and Precision Medicine.
Cancer discovery.
2021
Information Resource
GET IT
Times cited: 268 -
Metastasis and Immune Evasion from Extracellular cGAMP Hydrolysis.
Cancer discovery.
2021
Academic Article
GET IT
Times cited: 168 -
The spatial landscape of lung pathology during COVID-19 progression.
Nature.
2021
Academic Article
GET IT
Times cited: 226 - Towards artificial intelligence-driven pathology assessment for hematological malignancies. Blood cancer discovery. 2021 Academic Article GET IT
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A Deep Learning Approach to Diagnostic Classification of Prostate Cancer Using Pathology-Radiology Fusion.
Journal of magnetic resonance imaging : JMRI.
2021
Academic Article
GET IT
Times cited: 51 - Genome-wide investigation identifies a rare copy-number variant burden associated with human spina bifida. Genetics in medicine : official journal of the American College of Medical Genetics. 2021 Academic Article GET IT
- Building biorepositories in the midst of a pandemic. Journal of clinical and translational science. 2021 Academic Article GET IT
- Whole-genome characterization of lung adenocarcinomas lacking the RTK/RAS/RAF pathway. Cell reports. 2021 Academic Article GET IT
-
Exogenous and Endogenous Sources of Serine Contribute to Colon Cancer Metabolism, Growth, and Resistance to 5-Fluorouracil.
Cancer research.
2021
Academic Article
GET IT
Times cited: 70 -
Chemical systems biology reveals mechanisms of glucocorticoid receptor signaling.
Nature chemical biology.
2021
Academic Article
GET IT
Times cited: 1 -
Smc3 dosage regulates B cell transit through germinal centers and restricts their malignant transformation.
Nature immunology.
2021
Academic Article
GET IT
Times cited: 25 -
Profiling of immune dysfunction in COVID-19 patients allows early prediction of disease progression.
Life science alliance.
2020
Academic Article
GET IT
Times cited: 53 -
Leveraging phenotypic variability to identify genetic interactions in human phenotypes.
American journal of human genetics.
2020
Academic Article
GET IT
Times cited: 31 -
Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture.
Nature.
2020
Academic Article
GET IT
Times cited: 154 -
Common germline-somatic variant interactions in advanced urothelial cancer.
Nature communications.
2020
Academic Article
GET IT
Times cited: 23 -
Performance Characteristics of a Targeted Sequencing Platform for Simultaneous Detection of Single Nucleotide Variants, Insertions/Deletions, Copy Number Alterations, and Gene Fusions in Cancer Genome.
Archives of pathology & laboratory medicine.
2020
Academic Article
GET IT
Times cited: 1 -
High-resolution mouse subventricular zone stem-cell niche transcriptome reveals features of lineage, anatomy, and aging.
Proceedings of the National Academy of Sciences of the United States of America.
2020
Academic Article
GET IT
Times cited: 33 -
Unique Immune Cell Coactivators Specify Locus Control Region Function and Cell Stage.
Molecular cell.
2020
Academic Article
GET IT
Times cited: 24 -
Clinical, regional, and genetic characteristics of Covid-19 patients from UK Biobank.
PloS one.
2020
Academic Article
GET IT
Times cited: 34 -
Integration of whole-exome and anchored PCR-based next generation sequencing significantly increases detection of actionable alterations in precision oncology.
Translational oncology.
2020
Academic Article
GET IT
Times cited: 9 -
Precision medicine and artificial intelligence: overview and relevance to reproductive medicine.
Fertility and sterility.
2020
Information Resource
GET IT
Times cited: 4 -
Predictive modeling in reproductive medicine: Where will the future of artificial intelligence research take us?.
Fertility and sterility.
2020
Information Resource
GET IT
Times cited: 3 -
Limitations of Detecting Genetic Variants from the RNA Sequencing Data in Tissue and Fine-Needle Aspiration Samples.
Thyroid : official journal of the American Thyroid Association.
2020
Academic Article
GET IT
Times cited: 24 -
Distinct Classes of Complex Structural Variation Uncovered across Thousands of Cancer Genome Graphs.
Cell.
2020
Academic Article
GET IT
Times cited: 131 -
Adaptable haemodynamic endothelial cells for organogenesis and tumorigenesis.
Nature.
2020
Academic Article
GET IT
Times cited: 153 -
The future of precision medicine: towards a more predictive personalized medicine.
Emerging topics in life sciences.
2020
Information Resource
GET IT
Times cited: 1 -
A machine learning and network framework to discover new indications for small molecules.
PLoS computational biology.
2020
Academic Article
GET IT
Times cited: 13 - Selective dysregulation of ROCK2 activity promotes aberrant transcriptional networks in ABC diffuse large B-cell lymphoma. Scientific reports. 2020 Academic Article GET IT
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Molecular Profiles of Mixed Endometrial Carcinoma.
The American journal of surgical pathology.
2020
Academic Article
GET IT
Times cited: 3 -
Immunoprophylactic and immunotherapeutic control of hormone receptor-positive breast cancer.
Nature communications.
2020
Academic Article
GET IT
Times cited: 84 -
Urinary Cell Transcriptome Profiling and Identification of ITM2A, SLAMF6, and IKZF3 as Biomarkers of Acute Rejection in Human Kidney Allografts.
Transplantation direct.
2020
Academic Article
GET IT
Times cited: 8 -
Multicenter Phase II Study of Cabazitaxel in Advanced Gastroesophageal Cancer: Association of HER2 Expression and M2-Like Tumor-Associated Macrophages with Patient Outcome.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2020
Academic Article
GET IT
Times cited: 9 -
A reference single-cell transcriptomic atlas of human skeletal muscle tissue reveals bifurcated muscle stem cell populations.
Skeletal muscle.
2020
Academic Article
GET IT
Times cited: 108 -
TBL1XR1 Mutations Drive Extranodal Lymphoma by Inducing a Pro-tumorigenic Memory Fate.
Cell.
2020
Academic Article
GET IT
Times cited: 71 -
Small Cell Carcinoma of the Ovary, Hypercalcemic Type (SCCOHT) beyond SMARCA4 Mutations: A Comprehensive Genomic Analysis.
Cells.
2020
Academic Article
GET IT
Times cited: 30 -
Lineage Reversion Drives WNT Independence in Intestinal Cancer.
Cancer discovery.
2020
Academic Article
GET IT
Times cited: 47 -
The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple-Negative Breast Cancer.
Cancer discovery.
2020
Academic Article
GET IT
Times cited: 31 -
Fusions involving BCOR and CREBBP are rare events in infiltrating glioma.
Acta neuropathologica communications.
2020
Academic Article
GET IT
Times cited: 18 -
Single-cell profiling reveals an endothelium-mediated immunomodulatory pathway in the eye choroid.
The Journal of experimental medicine.
2020
Academic Article
GET IT
Times cited: 57 -
Epigenetic reprogramming sensitizes immunologically silent EBV+ lymphomas to virus-directed immunotherapy.
Blood.
2020
Academic Article
GET IT
Times cited: 44 -
Epithelial plasticity can generate multi-lineage phenotypes in human and murine bladder cancers.
Nature communications.
2020
Academic Article
GET IT
Times cited: 42 -
A novel prognostic two-gene signature for triple negative breast cancer.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.
2020
Academic Article
GET IT
Times cited: 7 -
Identification of Distinct Heterogenic Subtypes and Molecular Signatures Associated with African Ancestry in Triple Negative Breast Cancer Using Quantified Genetic Ancestry Models in Admixed Race Populations.
Cancers.
2020
Academic Article
GET IT
Times cited: 23 -
Mutant EZH2 Induces a Pre-malignant Lymphoma Niche by Reprogramming the Immune Response.
Cancer cell.
2020
Academic Article
GET IT
Times cited: 96 -
CIC is a critical regulator of neuronal differentiation.
JCI insight.
2020
Academic Article
GET IT
Times cited: 22 -
Demographic and genetic factors influence the abundance of infiltrating immune cells in human tissues.
Nature communications.
2020
Academic Article
GET IT
Times cited: 28 - ABEMUS: platform-specific and data-informed detection of somatic SNVs in cfDNA. Bioinformatics (Oxford, England). 2020 Academic Article GET IT
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Adenomyoepithelial tumors of the breast: molecular underpinnings of a rare entity.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.
2020
Academic Article
GET IT
Times cited: 4 -
Integrative multiplatform molecular profiling of benign prostatic hyperplasia identifies distinct subtypes.
Nature communications.
2020
Academic Article
GET IT
Times cited: 41 -
Tumor Microenvironment Is Critical for the Maintenance of Cellular States Found in Primary Glioblastomas.
Cancer discovery.
2020
Academic Article
GET IT
Times cited: 30 -
Circulating tumor DNA profile recognizes transformation to castration-resistant neuroendocrine prostate cancer.
The Journal of clinical investigation.
2020
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Single-Cell Analysis of the Muscle Stem Cell Hierarchy Identifies Heterotypic Communication Signals Involved in Skeletal Muscle Regeneration.
Cell reports.
2020
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Times cited: 196 - SLFN11 Expression in Advanced Prostate Cancer and Response to Platinum-based Chemotherapy. Molecular cancer therapeutics. 2020 Academic Article GET IT
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The novel lncRNA BlackMamba controls the neoplastic phenotype of ALK- anaplastic large cell lymphoma by regulating the DNA helicase HELLS.
Leukemia.
2020
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Urinary cell transcriptomics and acute rejection in human kidney allografts.
JCI insight.
2020
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The aging skin microenvironment dictates stem cell behavior.
Proceedings of the National Academy of Sciences of the United States of America.
2020
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Computational methods in tumor immunology.
Methods in enzymology.
2020
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Inhibition of EZH2 Catalytic Activity Selectively Targets a Metastatic Subpopulation in Triple-Negative Breast Cancer.
Cell reports.
2020
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Stable reduction of STARD4 alters cholesterol regulation and lipid homeostasis.
Biochimica et biophysica acta. Molecular and cell biology of lipids.
2020
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A Bayesian machine learning approach for drug target identification using diverse data types.
Nature communications.
2019
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Differential Contributions of Pre- and Post-EMT Tumor Cells in Breast Cancer Metastasis.
Cancer research.
2019
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Organotypic tumor slice cultures provide a versatile platform for immuno-oncology and drug discovery.
Oncoimmunology.
2019
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Deep learning-based classification of mesothelioma improves prediction of patient outcome.
Nature medicine.
2019
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Integrative Molecular Analysis of Patients With Advanced and Metastatic Cancer.
JCO precision oncology.
2019
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Clinical features of neuroendocrine prostate cancer.
European journal of cancer.
2019
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Exploring tumor clonal evolution in bone marrow of patients with diffuse large B-cell lymphoma by deep IGH sequencing and its potential relevance in relapse.
Blood cancer journal.
2019
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Cancer-Specific Thresholds Adjust for Whole Exome Sequencing-based Tumor Mutational Burden Distribution.
JCO precision oncology.
2019
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Supplemental estrogen and caloric restriction reduce obesity-induced periprostatic white adipose inflammation in mice.
Carcinogenesis.
2019
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Obesity-Associated Extracellular Matrix Remodeling Promotes a Macrophage Phenotype Similar to Tumor-Associated Macrophages.
The American journal of pathology.
2019
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Landscape of innate immune system transcriptome and acute T cell-mediated rejection of human kidney allografts.
JCI insight.
2019
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Upper tract urothelial carcinoma has a luminal-papillary T-cell depleted contexture and activated FGFR3 signaling.
Nature communications.
2019
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Artificial intelligence: its applications in reproductive medicine and the assisted reproductive technologies.
Fertility and sterility.
2019
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N-Myc-mediated epigenetic reprogramming drives lineage plasticity in advanced prostate cancer.
The Journal of clinical investigation.
2019
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Imipridone ONC212 activates orphan G protein-coupled receptor GPR132 and integrated stress response in acute myeloid leukemia.
Leukemia.
2019
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A Recurrent Activating Missense Mutation in Waldenström Macroglobulinemia Affects the DNA Binding of the ETS Transcription Factor SPI1 and Enhances Proliferation.
Cancer discovery.
2019
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Precision Targeting with EZH2 and HDAC Inhibitors in Epigenetically Dysregulated Lymphomas.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2019
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Times cited: 58 - Deep learning enables robust assessment and selection of human blastocysts after in vitro fertilization. NPJ digital medicine. 2019 Academic Article GET IT
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CHD1 Loss Alters AR Binding at Lineage-Specific Enhancers and Modulates Distinct Transcriptional Programs to Drive Prostate Tumorigenesis.
Cancer cell.
2019
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Delta-like protein 3 expression and therapeutic targeting in neuroendocrine prostate cancer.
Science translational medicine.
2019
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Dynamic transcriptome profiles within spermatogonial and spermatocyte populations during postnatal testis maturation revealed by single-cell sequencing.
PLoS genetics.
2019
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Long non-coding RNAs discriminate the stages and gene regulatory states of human humoral immune response.
Nature communications.
2019
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Generation of pulmonary neuroendocrine cells and SCLC-like tumors from human embryonic stem cells.
The Journal of experimental medicine.
2019
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The Transcriptional Regulator Sin3A Contributes to the Oncogenic Potential of STAT3.
Cancer research.
2019
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Predicting peptide presentation by major histocompatibility complex class I: an improved machine learning approach to the immunopeptidome.
BMC bioinformatics.
2019
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Drug-Induced Expression-Based Computational Repurposing of Small Molecules Affecting Transcription Factor Activity.
Methods in molecular biology (Clifton, N.J.).
2019
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UCHL1 loss alters the cell-cycle in metastatic pancreatic neuroendocrine tumors.
Endocrine-related cancer.
2019
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Epigenetic analysis identifies factors driving racial disparity in prostate cancer.
Cancer reports (Hoboken, N.J.).
2018
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Revisiting the initial steps of sexual development in the malaria parasite Plasmodium falciparum.
Nature microbiology.
2018
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Association of T-Cell Receptor Repertoire Use With Response to Combined Trastuzumab-Lapatinib Treatment of HER2-Positive Breast Cancer: Secondary Analysis of the NeoALTTO Randomized Clinical Trial.
JAMA oncology.
2018
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Prostaglandin E2 down-regulates sirtuin 1 (SIRT1), leading to elevated levels of aromatase, providing insights into the obesity-breast cancer connection.
The Journal of biological chemistry.
2018
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CHL1 expression differentiates Hürthle cell carcinoma from benign Hürthle cell nodules.
Journal of surgical oncology.
2018
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TET2 Deficiency Causes Germinal Center Hyperplasia, Impairs Plasma Cell Differentiation, and Promotes B-cell Lymphomagenesis.
Cancer discovery.
2018
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Colonoscopic-Guided Pinch Biopsies in Mice as a Useful Model for Evaluating the Roles of Host and Luminal Factors in Colonic Inflammation.
The American journal of pathology.
2018
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Activating Transcription Factor 4 Modulates TGFβ-Induced Aggressiveness in Triple-Negative Breast Cancer via SMAD2/3/4 and mTORC2 Signaling.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2018
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Immune reprogramming via PD-1 inhibition enhances early-stage lung cancer survival.
JCI insight.
2018
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Patient derived organoids to model rare prostate cancer phenotypes.
Nature communications.
2018
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Accelerated lipid catabolism and autophagy are cancer survival mechanisms under inhibited glutaminolysis.
Cancer letters.
2018
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Phenotype, penetrance, and treatment of 133 cytotoxic T-lymphocyte antigen 4-insufficient subjects.
The Journal of allergy and clinical immunology.
2018
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Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy.
Molecular cell.
2018
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Rapid identification of BCR/ABL1-like acute lymphoblastic leukaemia patients using a predictive statistical model based on quantitative real time-polymerase chain reaction: clinical, prognostic and therapeutic implications.
British journal of haematology.
2018
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A Randomized Multicenter Phase II Study of Docosahexaenoic Acid in Patients with a History of Breast Cancer, Premalignant Lesions, or Benign Breast Disease.
Cancer prevention research (Philadelphia, Pa.).
2018
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Tailoring CD19xCD3-DART exposure enhances T-cells to eradication of B-cell neoplasms.
Oncoimmunology.
2018
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Chromosomal instability drives metastasis through a cytosolic DNA response.
Nature.
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AICDA drives epigenetic heterogeneity and accelerates germinal center-derived lymphomagenesis.
Nature communications.
2018
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The ERβ4 variant induces transformation of the normal breast mammary epithelial cell line MCF-10A; the ERβ variants ERβ2 and ERβ5 increase aggressiveness of TNBC by regulation of hypoxic signaling.
Oncotarget.
2018
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Bioinformatics Approaches to Predict Drug Responses from Genomic Sequencing.
Methods in molecular biology (Clifton, N.J.).
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Deep Convolutional Neural Networks Enable Discrimination of Heterogeneous Digital Pathology Images.
EBioMedicine.
2017
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Bone biopsy protocol for advanced prostate cancer in the era of precision medicine.
Cancer.
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HN1L Promotes Triple-Negative Breast Cancer Stem Cells through LEPR-STAT3 Pathway.
Stem cell reports.
2017
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STMN1 is Overexpressed in Adrenocortical Carcinoma and Promotes a More Aggressive Phenotype In Vitro.
Annals of surgical oncology.
2017
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Identifying and Targeting Sporadic Oncogenic Genetic Aberrations in Mouse Models of Triple-Negative Breast Cancer.
Cancer discovery.
2017
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TET proteins safeguard bivalent promoters from de novo methylation in human embryonic stem cells.
Nature genetics.
2017
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EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop.
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2017
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Single-cell RNA sequencing reveals a signature of sexual commitment in malaria parasites.
Nature.
2017
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A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product.
Cell metabolism.
2017
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Broad Targeting Specificity during Bacterial Type III CRISPR-Cas Immunity Constrains Viral Escape.
Cell host & microbe.
2017
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Cancer stem cell-related gene expression as a potential biomarker of response for first-in-class imipridone ONC201 in solid tumors.
PloS one.
2017
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EthSEQ: ethnicity annotation from whole exome sequencing data.
Bioinformatics (Oxford, England).
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R-Spondin chromosome rearrangements drive Wnt-dependent tumour initiation and maintenance in the intestine.
Nature communications.
2017
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Inherited determinants of early recurrent somatic mutations in prostate cancer.
Nature communications.
2017
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Next-Generation Rapid Autopsies Enable Tumor Evolution Tracking and Generation of Preclinical Models.
JCO precision oncology.
2017
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Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma.
Journal of visualized experiments : JoVE.
2017
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Global miRNA expression analysis identifies novel key regulators of plasma cell differentiation and malignant plasma cell.
Nucleic acids research.
2017
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Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells.
Nature.
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Concerted regulation of retinal pigment epithelium basement membrane and barrier function by angiocrine factors.
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2017
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An integrated model for detecting significant chromatin interactions from high-resolution Hi-C data.
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Conversion of adult endothelium to immunocompetent haematopoietic stem cells.
Nature.
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Widespread Mitotic Bookmarking by Histone Marks and Transcription Factors in Pluripotent Stem Cells.
Cell reports.
2017
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Identification of a nucleoside analog active against adenosine kinase-expressing plasma cell malignancies.
The Journal of clinical investigation.
2017
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The cancer precision medicine knowledge base for structured clinical-grade mutations and interpretations.
Journal of the American Medical Informatics Association : JAMIA.
2017
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Stem Cell Lineage Infidelity Drives Wound Repair and Cancer.
Cell.
2017
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Epigenetic Identity in AML Depends on Disruption of Nonpromoter Regulatory Elements and Is Affected by Antagonistic Effects of Mutations in Epigenetic Modifiers.
Cancer discovery.
2017
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Oncogenic BRAF disrupts thyroid morphogenesis and function via twist expression.
eLife.
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Personalized In Vitro and In Vivo Cancer Models to Guide Precision Medicine.
Cancer discovery.
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Cabozantinib Eradicates Advanced Murine Prostate Cancer by Activating Antitumor Innate Immunity.
Cancer discovery.
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BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells.
Cancer discovery.
2017
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Melanoma genome evolution across species.
BMC genomics.
2017
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Effective Combination Therapies for B-cell Lymphoma Predicted by a Virtual Disease Model.
Cancer research.
2017
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Regulatory elements in molecular networks.
Wiley interdisciplinary reviews. Systems biology and medicine.
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Sox17 drives functional engraftment of endothelium converted from non-vascular cells.
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A Computational Approach for Identifying Synergistic Drug Combinations.
PLoS computational biology.
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Endothelial-specific inhibition of NF-κB enhances functional haematopoiesis.
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Mechanisms of Acquired Drug Resistance to the HDAC6 Selective Inhibitor Ricolinostat Reveals Rational Drug-Drug Combination with Ibrutinib.
Clinical cancer research : an official journal of the American Association for Cancer Research.
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Therapeutic efficacy of the bromodomain inhibitor OTX015/MK-8628 in ALK-positive anaplastic large cell lymphoma: an alternative modality to overcome resistant phenotypes.
Oncotarget.
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Oncotarget.
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CREBBP Inactivation Promotes the Development of HDAC3-Dependent Lymphomas.
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N-Myc Induces an EZH2-Mediated Transcriptional Program Driving Neuroendocrine Prostate Cancer.
Cancer cell.
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A Data-Driven Approach to Predicting Successes and Failures of Clinical Trials.
Cell chemical biology.
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Multi-tiered Reorganization of the Genome during B Cell Affinity Maturation Anchored by a Germinal Center-Specific Locus Control Region.
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An Epigenomic Approach to Improving Response to Neoadjuvant Cisplatin Chemotherapy in Bladder Cancer.
Biomolecules.
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Deep Sequencing of T-cell Receptor DNA as a Biomarker of Clonally Expanded TILs in Breast Cancer after Immunotherapy.
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EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis.
Cancer cell.
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KLF4: A new player in plasma cell development.
Cell cycle (Georgetown, Tex.).
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Single-cell TCRseq: paired recovery of entire T-cell alpha and beta chain transcripts in T-cell receptors from single-cell RNAseq.
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Development and validation of a whole-exome sequencing test for simultaneous detection of point mutations, indels and copy-number alterations for precision cancer care.
NPJ genomic medicine.
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Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer.
The New England journal of medicine.
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Epigenetic profiles signify cell fate plasticity in unipotent spermatogonial stem and progenitor cells.
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Predictive features of ligand-specific signaling through the estrogen receptor.
Molecular systems biology.
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Disruption of Adipose Rab10-Dependent Insulin Signaling Causes Hepatic Insulin Resistance.
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Nuclear envelope expansion is crucial for proper chromosomal segregation during a closed mitosis.
Journal of cell science.
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Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer.
Nature medicine.
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Prostate-Specific Membrane Antigen Is a Potential Antiangiogenic Target in Adrenocortical Carcinoma.
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Combinatorial targeting of nuclear export and translation of RNA inhibits aggressive B-cell lymphomas.
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Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH.
Science (New York, N.Y.).
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EBV-miR-BHRF1-2 targets PRDM1/Blimp1: potential role in EBV lymphomagenesis.
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Transcriptome sequencing reveals thousands of novel long non-coding RNAs in B cell lymphoma.
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Prediction of Genetic Interactions Using Machine Learning and Network Properties.
Frontiers in bioengineering and biotechnology.
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Cell.
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The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development.
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DNA Methylation Dynamics of Germinal Center B Cells Are Mediated by AID.
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Obesity-dependent changes in interstitial ECM mechanics promote breast tumorigenesis.
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Deficiency of UBE2T, the E2Â Ubiquitin Ligase Necessary for FANCD2 and FANCI Ubiquitination, Causes FA-T Subtype of Fanconi Anemia.
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Identification of Reprogrammed Myeloid Cell Transcriptomes in NSCLC.
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The chromatin Remodeler CHD8 is required for activation of progesterone receptor-dependent enhancers.
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The Journal of clinical investigation.
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Proceedings of the National Academy of Sciences of the United States of America.
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Lymphoblastic transformation of follicular lymphoma: a clinicopathologic and molecular analysis of 7 patients.
Human pathology.
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Circulation research.
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Histone variant H3.3 is an essential maternal factor for oocyte reprogramming.
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Molecular human reproduction.
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Akt suppression of TGFβ signaling contributes to the maintenance of vascular identity in embryonic stem cell-derived endothelial cells.
Stem cells (Dayton, Ohio).
2014
Academic Article
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Times cited: 21 -
Molecular diagnosis of autosomal dominant polycystic kidney disease using next-generation sequencing.
The Journal of molecular diagnostics : JMD.
2013
Academic Article
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Times cited: 59 -
Genetic regulation of vesiculogenesis and immunomodulation in Mycobacterium tuberculosis.
Proceedings of the National Academy of Sciences of the United States of America.
2013
Academic Article
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Times cited: 81 -
EZH2 mutations are frequent and represent an early event in follicular lymphoma.
Blood.
2013
Academic Article
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Times cited: 265 -
Synergistic activation of inflammatory cytokine genes by interferon-γ-induced chromatin remodeling and toll-like receptor signaling.
Immunity.
2013
Academic Article
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Times cited: 235 -
A hybrid mechanism of action for BCL6 in B cells defined by formation of functionally distinct complexes at enhancers and promoters.
Cell reports.
2013
Academic Article
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Times cited: 148 -
Molecular signatures of tissue-specific microvascular endothelial cell heterogeneity in organ maintenance and regeneration.
Developmental cell.
2013
Academic Article
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Times cited: 488 -
A stable transcription factor complex nucleated by oligomeric AML1-ETO controls leukaemogenesis.
Nature.
2013
Academic Article
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The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry.
Nature neuroscience.
2013
Academic Article
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Times cited: 270 -
AID stabilizes stem-cell phenotype by removing epigenetic memory of pluripotency genes.
Nature.
2013
Academic Article
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Times cited: 80 -
EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation.
Cancer cell.
2013
Academic Article
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Times cited: 668 -
A novel approach for characterizing microsatellite instability in cancer cells.
PloS one.
2013
Academic Article
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Times cited: 41 -
Punctuated evolution of prostate cancer genomes.
Cell.
2013
Academic Article
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Times cited: 1006 -
Downregulation of FOXP1 is required during germinal center B-cell function.
Blood.
2013
Academic Article
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Times cited: 56 -
Inferring chromatin-bound protein complexes from genome-wide binding assays.
Genome research.
2013
Academic Article
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Times cited: 29 - Epigenomic alterations in localized and advanced prostate cancer. Neoplasia (New York, N.Y.). 2013 Academic Article GET IT
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Metabolic alterations in lung cancer-associated fibroblasts correlated with increased glycolytic metabolism of the tumor.
Molecular cancer research : MCR.
2013
Academic Article
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Times cited: 77 -
Porous materials with optimal adsorption thermodynamics and kinetics for CO2 separation.
Nature.
2013
Academic Article
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Times cited: 1504 -
NFIB is a governor of epithelial-melanocyte stem cell behaviour in a shared niche.
Nature.
2013
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Times cited: 134 -
Aberration in DNA methylation in B-cell lymphomas has a complex origin and increases with disease severity.
PLoS genetics.
2013
Academic Article
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Times cited: 100 -
Epigenetic repression of miR-31 disrupts androgen receptor homeostasis and contributes to prostate cancer progression.
Cancer research.
2012
Academic Article
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Times cited: 156 -
Antagonistic function of the RNA-binding protein HuR and miR-200b in post-transcriptional regulation of vascular endothelial growth factor-A expression and angiogenesis.
The Journal of biological chemistry.
2012
Academic Article
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Times cited: 71 -
Human ESC-derived hemogenic endothelial cells undergo distinct waves of endothelial to hematopoietic transition.
Blood.
2012
Academic Article
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Times cited: 65 -
Integrative epigenomic analysis identifies biomarkers and therapeutic targets in adult B-acute lymphoblastic leukemia.
Cancer discovery.
2012
Academic Article
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Times cited: 78 -
Efficient direct reprogramming of mature amniotic cells into endothelial cells by ETS factors and TGFβ suppression.
Cell.
2012
Academic Article
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Times cited: 192 -
Genome-wide detection of genes targeted by non-Ig somatic hypermutation in lymphoma.
PloS one.
2012
Academic Article
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Times cited: 44 -
Oncogene-mediated alterations in chromatin conformation.
Proceedings of the National Academy of Sciences of the United States of America.
2012
Academic Article
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Times cited: 114 -
Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons.
Cell.
2012
Academic Article
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Times cited: 3083 -
Calcimimetics versus parathyroidectomy for treatment of primary hyperparathyroidism: retrospective chart analysis of a prospective database.
Annals of surgery.
2012
Academic Article
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Times cited: 25 -
Concordant signaling pathways produced by pesticide exposure in mice correspond to pathways identified in human Parkinson's disease.
PloS one.
2012
Academic Article
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Times cited: 46 -
Identification of functionally active, low frequency copy number variants at 15q21.3 and 12q21.31 associated with prostate cancer risk.
Proceedings of the National Academy of Sciences of the United States of America.
2012
Academic Article
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Times cited: 43 -
A panel of four miRNAs accurately differentiates malignant from benign indeterminate thyroid lesions on fine needle aspiration.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2012
Academic Article
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Times cited: 113 -
Using transcriptome sequencing to identify mechanisms of drug action and resistance.
Nature chemical biology.
2012
Academic Article
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Times cited: 139 -
Faster sequencers, larger datasets, new challenges.
Genome biology.
2012
Academic Article
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Times cited: 35 -
DNA methyltransferase 1 and DNA methylation patterning contribute to germinal center B-cell differentiation.
Blood.
2011
Academic Article
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Times cited: 127 -
An integrated ChIP-seq analysis platform with customizable workflows.
BMC bioinformatics.
2011
Academic Article
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Times cited: 70 -
Large-scale discovery and characterization of protein regulatory motifs in eukaryotes.
PloS one.
2010
Academic Article
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Times cited: 30 -
Mutations in FLVCR1 cause posterior column ataxia and retinitis pigmentosa.
American journal of human genetics.
2010
Academic Article
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Times cited: 83 -
Identification and genome-wide prediction of DNA binding specificities for the ApiAP2 family of regulators from the malaria parasite.
PLoS pathogens.
2010
Academic Article
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Times cited: 192 -
EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis.
Blood.
2010
Academic Article
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Times cited: 257 -
DNA methylation signatures define molecular subtypes of diffuse large B-cell lymphoma.
Blood.
2010
Academic Article
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Times cited: 131 -
Revealing global regulatory perturbations across human cancers.
Molecular cell.
2009
Academic Article
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Times cited: 163 -
DISPARE: DIScriminative PAttern REfinement for Position Weight Matrices.
BMC bioinformatics.
2009
Academic Article
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Times cited: 6 -
Coupling of zygotic transcription to mitotic control at the Drosophila mid-blastula transition.
Development (Cambridge, England).
2009
Academic Article
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Times cited: 87 -
The BCL6 transcriptional program features repression of multiple oncogenes in primary B cells and is deregulated in DLBCL.
Blood.
2009
Academic Article
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Times cited: 191 -
let-7 Overexpression leads to an increased fraction of cells in G2/M, direct down-regulation of Cdc34, and stabilization of Wee1 kinase in primary fibroblasts.
The Journal of biological chemistry.
2009
Academic Article
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Times cited: 98 -
A universal framework for regulatory element discovery across all genomes and data types.
Molecular cell.
2007
Academic Article
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Times cited: 230 -
Unmasking activation of the zygotic genome using chromosomal deletions in the Drosophila embryo.
PLoS biology.
2007
Academic Article
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Times cited: 217 -
Developing a systems-level understanding of gene expression.
Genome biology.
2007
Conference Paper
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Times cited: 2 -
Fastcompare: a nonalignment approach for genome-scale discovery of DNA and mRNA regulatory elements using network-level conservation.
Methods in molecular biology (Clifton, N.J.).
2007
Academic Article
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Times cited: 7 -
Ab initio genotype-phenotype association reveals intrinsic modularity in genetic networks.
Molecular systems biology.
2006
Academic Article
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Times cited: 47 -
Revealing posttranscriptional regulatory elements through network-level conservation.
PLoS computational biology.
2005
Academic Article
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Times cited: 68 -
Fast and systematic genome-wide discovery of conserved regulatory elements using a non-alignment based approach.
Genome biology.
2005
Academic Article
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Times cited: 107 -
IMGT/PhyloGene: an on-line tool for comparative analysis of immunoglobulin and T cell receptor genes.
Developmental and comparative immunology.
2003
Academic Article
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Times cited: 31 -
Reconstructing the duplication history of tandemly repeated genes.
Molecular biology and evolution.
2002
Academic Article
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Times cited: 58