Wnt Signaling and Colorectal Cancer. Academic Article uri icon

Overview

abstract

  • The WNT signaling pathway is a critical mediator of tissue homeostasis and repair, and frequently co-opted during tumor development. Almost all colorectal cancers (CRC) demonstrate hyperactivation of the WNT pathway, which in many cases is believed to be the initiating and driving event. In this short review, we provide a focused overview of recent developments in our understanding of the WNT pathway in CRC, describe new research tools that are enabling a deeper understanding of WNT biology, and outline ongoing efforts to target this pathway therapeutically.

publication date

  • February 28, 2017

Identity

PubMed Central ID

  • PMC5391049

Scopus Document Identifier

  • 85014043316

Digital Object Identifier (DOI)

  • 10.1007/s11888-017-0354-9

PubMed ID

  • 28413363

Additional Document Info

volume

  • 13

issue

  • 2