selected publications
- Epigenetic regulation of chromosomal instability by EZH2 methyltransferase. Cancer discovery. 2025 Academic Article GET IT
 - Concurrent genetic and non-genetic resistance mechanisms to KRAS inhibition in CRC. 2025 GET IT
 - Genetic mechanisms of resistance to targeted KRAS inhibition. 2025 GET IT
 - Engineered microRNA scaffolds for potent gene silencing in vivo. Scientific reports. 2025 Academic Article GET IT
 - Molecular dynamics driving phenotypic divergence among KRAS mutants in pancreatic tumorigenesis. 2025 GET IT
 - A potent and selective TNKS2 inhibitor for tumor-selective WNT suppression. 2025 GET IT
 -     
    
    
                     Kinome-Focused CRISPR-Cas9 Screens in African Ancestry Patient-Derived Breast Cancer Organoids Identify Essential Kinases and Synergy of EGFR and FGFR1 Inhibition. 
 
                    Cancer research. 
            
             2025
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 5 -     
    
    
                     Selenocysteine tRNA methylation promotes oxidative stress resistance in melanoma metastasis. 
 
                    Nature cancer. 
            
             2024
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 7 - Scribble Deficiency Promotes Pancreatic Ductal Adenocarcinoma Development and Metastasis. Cancer research. 2024 Academic Article GET IT
 -     
    
    
                     Distinct clinical outcomes and biological features of specific KRAS mutants in human pancreatic cancer. 
 
                    Cancer cell. 
            
             2024
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 29 - The Orphan G Protein-Coupled Receptor GPR52 is a Novel Regulator of Breast Cancer Multicellular Organization. 2024 GET IT
 -     
    
    
                     How CRISPR Is Revolutionizing the Generation of New Models for Cancer Research. 
 
                    Cold Spring Harbor perspectives in medicine.
            
             2024
             
			
			
			
			
			
			Review
 			GET IT
 			
Times cited: 2 -     
    
    
                     Serine Supports Epithelial and Immune Cell Function in Colitis. 
 
                    The American journal of pathology. 
            
             2024
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 3 -     
    
    
                     Alveolar Differentiation Drives Resistance to KRAS Inhibition in Lung Adenocarcinoma. 
 
                    Cancer discovery. 
            
             2024
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 28 - Solid tumor growth depends on an intricate equilibrium of malignant cell states. 2023 GET IT
 -     
    
    
                     Oncogenic context shapes the fitness landscape of tumor suppression. 
 
                    Nature communications. 
            
             2023
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 16 - Alveolar differentiation drives resistance to KRAS inhibition in lung adenocarcinoma. 2023 GET IT
 - Generation of precision preclinical cancer models using regulated in vivo base editing. Nature biotechnology. 2023 Academic Article GET IT
 -     
    
    
                     Novel genetically engineered mouse models for clear cell renal cell carcinoma. 
 
                    Scientific reports. 
            
             2023
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 3 -     
    
    
                     Obesity promotes breast epithelium DNA damage in women carrying a germline mutation in BRCA1 or BRCA2. 
 
                    Science translational medicine. 
            
             2023
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 1 -     
    
    
                     Comprehensive microRNA analysis across genome-edited colorectal cancer organoid models reveals miR-24 as a candidate regulator of cell survival. 
 
                    BMC genomics. 
            
             2022
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 2 -     
    
    
                     Endogenous spacing enables co-processing of microRNAs and efficient combinatorial RNAi. 
 
                    Cell reports methods. 
            
             2022
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 8 -     
    
    
                     Chromatin profiles classify castration-resistant prostate cancers suggesting therapeutic targets. 
 
                    Science (New York, N.Y.). 
            
             2022
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 157 -     
    
    
                     A preclinical platform for assessing antitumor effects and systemic toxicities of cancer drug targets. 
 
                    Proceedings of the National Academy of Sciences of the United States of America. 
            
             2022
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 7 -     
    
    
                     CRISPR in cancer biology and therapy. 
 
                    Nature reviews. Cancer.
            
             2022
             
			
			
			
			
			
			Review
 			GET IT
 			
Times cited: 261 -     
    
    
                     Base editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants. 
 
                    Nature biotechnology. 
            
             2022
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 73 - Mitochondrial Ndufa4l2 Enhances Deposition of Lipids and Expression of Ca9 in the TRACK Model of Early Clear Cell Renal Cell Carcinoma. Frontiers in oncology. 2021 Academic Article GET IT
 -     
    
    
                     RB depletion is required for the continuous growth of tumors initiated by loss of RB. 
 
                    PLoS genetics. 
            
             2021
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 7 -     
    
    
                     Engineering chromosome rearrangements in cancer. 
 
                    Disease models & mechanisms.
            
             2021
             
			
			
			
			
			
			Review
 			GET IT
 			
Times cited: 7 -     
    
    
                     WNT as a Driver and Dependency in Cancer. 
 
                    Cancer discovery.
            
             2021
             
			
			
			
			
			
			Review
 			GET IT
 			
Times cited: 200 -     
    
    
                     Dietary fructose improves intestinal cell survival and nutrient absorption. 
 
                    Nature. 
            
             2021
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 1 -     
    
    
                     Revealing ARID1A Function in Gastric Cancer from the Bottom Up. 
 
                    Cancer discovery.
            
             2021
             
			
			
			
			
			
			 Comment
 			GET IT
 			
Times cited: 4 - Inducible hepatic expression of CREBH mitigates diet-induced obesity, insulin resistance, and hepatic steatosis in mice. The Journal of biological chemistry. 2021 Academic Article GET IT
 - KRAS mutant rectal cancer cells interact with surrounding fibroblasts to deplete the extracellular matrix. Molecular oncology. 2021 Academic Article GET IT
 -     
    
    
                     Exogenous and Endogenous Sources of Serine Contribute to Colon Cancer Metabolism, Growth, and Resistance to 5-Fluorouracil. 
 
                    Cancer research. 
            
             2021
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 91 -     
    
    
                     EpCAM (CD326) Regulates Intestinal Epithelial Integrity and Stem Cells via Rho-Associated Kinase. 
 
                    Cells. 
            
             2021
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 13 -     
    
    
                     Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican. 
 
                    The Journal of experimental medicine. 
            
             2020
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 31 -     
    
    
                     Adaptable haemodynamic endothelial cells for organogenesis and tumorigenesis. 
 
                    Nature. 
            
             2020
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 195 -     
    
    
                     An In Vivo Kras Allelic Series Reveals Distinct Phenotypes of Common Oncogenic Variants. 
 
                    Cancer discovery. 
            
             2020
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 88 -     
    
    
                     Exploiting the Therapeutic Interaction of WNT Pathway Activation and Asparaginase for Colorectal Cancer Therapy. 
 
                    Cancer discovery. 
            
             2020
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 47 -     
    
    
                     Three-dimensional growth of breast cancer cells potentiates the anti-tumor effects of unacylated ghrelin and AZP-531. 
 
                    eLife. 
            
             2020
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 6 -     
    
    
                     Lineage Reversion Drives WNT Independence in Intestinal Cancer. 
 
                    Cancer discovery. 
            
             2020
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 58 - Base editing goes into hyperdrive. Nature cell biology. 2020 Comment GET IT
 -     
    
    
                     Generation of focal mutations and large genomic deletions in the pancreas using inducible in vivo genome editing. 
 
                    Carcinogenesis. 
            
             2020
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 8 -     
    
    
                     Zonation of Ribosomal DNA Transcription Defines a Stem Cell Hierarchy in Colorectal Cancer. 
 
                    Cell stem cell. 
            
             2020
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 68 -     
    
    
                     Somatic Tissue Engineering in Mouse Models Reveals an Actionable Role for WNT Pathway Alterations in Prostate Cancer Metastasis. 
 
                    Cancer discovery. 
            
             2020
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 41 -     
    
    
                     GO: a functional reporter system to identify and enrich base editing activity. 
 
                    Nucleic acids research. 
            
             2020
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 27 -     
    
    
                     Detection of Marker-Free Precision Genome Editing and Genetic Variation through the Capture of Genomic Signatures. 
 
                    Cell reports. 
            
             2020
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 10 -     
    
    
                     In situ CRISPR-Cas9 base editing for the development of genetically engineered mouse models of breast cancer. 
 
                    The EMBO journal. 
            
             2020
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 50 -     
    
    
                     Tankyrase inhibition sensitizes cells to CDK4 blockade. 
 
                    PloS one. 
            
             2019
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 7 -     
    
    
                     Adipsin preserves beta cells in diabetic mice and associates with protection from type 2 diabetes in humans. 
 
                    Nature medicine. 
            
             2019
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 130 -     
    
    
                     A rectal cancer organoid platform to study individual responses to chemoradiation. 
 
                    Nature medicine. 
            
             2019
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 417 -     
    
    
                     Preclinical murine platform to evaluate therapeutic countermeasures against radiation-induced gastrointestinal syndrome. 
 
                    Proceedings of the National Academy of Sciences of the United States of America. 
            
             2019
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 27 -     
    
    
                     Distinct Colorectal Cancer-Associated APC Mutations Dictate Response to Tankyrase Inhibition. 
 
                    Cancer discovery. 
            
             2019
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 65 -     
    
    
                     Systemic silencing of PHD2 causes reversible immune regulatory dysfunction. 
 
                    The Journal of clinical investigation. 
            
             2019
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 29 -     
    
    
                     PIP4Ks Suppress Insulin Signaling through a Catalytic-Independent Mechanism. 
 
                    Cell reports. 
            
             2019
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 42 -     
    
    
                     Base editing the mammalian genome. 
 
                    Methods (San Diego, Calif.).
            
             2019
             
			
			
			
			
			
			Review
 			GET IT
 			
Times cited: 15 -     
    
    
                     Adenine base editing in an adult mouse model of tyrosinaemia. 
 
                    Nature biomedical engineering. 
            
             2019
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 160 -     
    
    
                     Murine Liver Organoids as a Genetically Flexible System to Study Liver Cancer In Vivo and In Vitro. 
 
                    Hepatology communications. 
            
             2019
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 32 -     
    
    
                     Genetic Liver-Specific AMPK Activation Protects against Diet-Induced Obesity and NAFLD. 
 
                    Cell reports. 
            
             2019
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 239 -     
    
    
                     CRISPR: Stressed about p53?. 
 
                    Trends in molecular medicine.
            
             2018
             
			
			
			
			
			
			 Comment
 			GET IT
 			
Times cited: 6 -     
    
    
                     Optimized base editors enable efficient editing in cells, organoids and mice. 
 
                    Nature biotechnology. 
            
             2018
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 285 -     
    
    
                     R-Spondin chromosome rearrangements drive Wnt-dependent tumour initiation and maintenance in the intestine. 
 
                    Nature communications. 
            
             2017
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 95 -     
    
    
                     Transplantation of engineered organoids enables rapid generation of metastatic mouse models of colorectal cancer. 
 
                    Nature biotechnology. 
            
             2017
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 202 -     
    
    
                     Wnt Signaling and Colorectal Cancer. 
 
                    Current colorectal cancer reports. 
            
             2017
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 252 -     
    
    
                     Somatic Genome Editing Goes Viral. 
 
                    Trends in molecular medicine. 
            
             2016
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 2 -     
    
    
                     p53-Dependent Nestin Regulation Links Tumor Suppression to Cellular Plasticity in Liver Cancer.
              2016
  			GET IT
 			
Times cited: 17 -     
    
    
                     Pten loss promotes MAPK pathway dependency in HER2/neu breast carcinomas. 
 
                    Proceedings of the National Academy of Sciences of the United States of America. 
            
             2016
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 61 - Immunofluorescent Staining of Mouse Intestinal Stem Cells. Bio-protocol. 2016 Academic Article GET IT
 - Isolation, Culture, and Maintenance of Mouse Intestinal Stem Cells. Bio-protocol. 2016 Academic Article GET IT
 -     
    
    
                     Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration. 
 
                    Nature. 
            
             2015
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 915 -     
    
    
                     Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH. 
 
                    Science (New York, N.Y.). 
            
             2015
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 795 -     
    
    
                     Modeling Disease In Vivo With CRISPR/Cas9. 
 
                    Trends in molecular medicine.
            
             2015
             
			
			
			
			
			
			Review
 			GET IT
 			
Times cited: 92 -     
    
    
                     Transcriptional plasticity promotes primary and acquired resistance to BET inhibition. 
 
                    Nature. 
            
             2015
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 435 -     
    
    
                     Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer. 
 
                    Cell. 
            
             2015
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 430 -     
    
    
                     The polarity protein Scribble regulates myelination and remyelination in the central nervous system. 
 
                    PLoS biology. 
            
             2015
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 27 -     
    
    
                     Inducible in vivo genome editing with CRISPR-Cas9. 
 
                    Nature biotechnology. 
            
             2015
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 419 -     
    
    
                     Inducible in vivo silencing of Brd4 identifies potential toxicities of sustained BET protein inhibition. 
 
                    Cell reports. 
            
             2014
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 156 -     
    
    
                     p53-dependent Nestin regulation links tumor suppression to cellular plasticity in liver cancer. 
 
                    Cell. 
            
             2014
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 179 -     
    
    
                     Conditional reverse tet-transactivator mouse strains for the efficient induction of TRE-regulated transgenes in mice. 
 
                    PloS one. 
            
             2014
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 65 -     
    
    
                     A modular and flexible ESC-based mouse model of pancreatic cancer. 
 
                    Genes & development. 
            
             2014
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 65 -     
    
    
                     Suppression of eukaryotic initiation factor 4E prevents chemotherapy-induced alopecia. 
 
                    BMC pharmacology & toxicology. 
            
             2013
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 10 -     
    
    
                     Creating transgenic shRNA mice by recombinase-mediated cassette exchange. 
 
                    Cold Spring Harbor protocols. 
            
             2013
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 7 -     
    
    
                     Variability of inducible expression across the hematopoietic system of tetracycline transactivator transgenic mice. 
 
                    PloS one. 
            
             2013
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 24 -     
    
    
                     Life in the fast lane: mammalian disease models in the genomics era. 
 
                    Cell. 
            
             2012
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 65 -     
    
    
                     A pipeline for the generation of shRNA transgenic mice. 
 
                    Nature protocols. 
            
             2012
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 137 -     
    
    
                     SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia. 
 
                    The Journal of clinical investigation. 
            
             2011
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 151 -     
    
    
                     Reversible suppression of an essential gene in adult mice using transgenic RNA interference. 
 
                    Proceedings of the National Academy of Sciences of the United States of America. 
            
             2011
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 48 -     
    
    
                     A rapid and scalable system for studying gene function in mice using conditional RNA interference. 
 
                    Cell. 
            
             2011
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 263 -     
    
    
                     Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi. 
 
                    Nature biotechnology. 
            
             2010
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 219 -     
    
    
                     Loss of human Scribble cooperates with H-Ras to promote cell invasion through deregulation of MAPK signalling. 
 
                    Oncogene. 
            
             2008
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 141 -     
    
    
                     Polarity regulators and the control of epithelial architecture, cell migration, and tumorigenesis. 
 
                    International review of cytology.
            
             2007
             
			
			
			
			
			
			Review
 			GET IT
 			
Times cited: 103 -     
    
    
                     The Scribble and Par complexes in polarity and migration: friends or foes?. 
 
                    Trends in cell biology.
            
             2006
             
			
			
			
			
			
			Review
 			GET IT
 			
Times cited: 125 -     
    
    
                     The tumour-suppressor Scribble dictates cell polarity during directed epithelial migration: regulation of Rho GTPase recruitment to the leading edge. 
 
                    Oncogene. 
            
             2006
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 154 -     
    
    
                     A network of PDZ-containing proteins regulates T cell polarity and morphology during migration and immunological synapse formation. 
 
                    Immunity. 
            
             2005
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 223 -     
    
    
                     hScrib is a functional homologue of the Drosophila tumour suppressor Scribble. 
 
                    Oncogene. 
            
             2003
             
			
			
			
			
			
			Academic Article
 			GET IT
 			
Times cited: 99