CRISPR: Stressed about p53? uri icon

Overview

abstract

  • Two recent reports show that, in some contexts, CRISPR-mediated genome editing can lead to a p53-mediated stress response and cell-cycle arrest. These findings may help to explain why CRISPR-mediated genetic manipulation in different cell types leads to dissimilar outcomes, and highlights the need for a better understanding of the factors that influence effective genome editing in vitro and in vivo.

publication date

  • July 17, 2018

Research

keywords

  • Clustered Regularly Interspaced Short Palindromic Repeats
  • Gene Editing

Identity

Scopus Document Identifier

  • 85049866718

Digital Object Identifier (DOI)

  • 10.1016/j.molmed.2018.06.010

PubMed ID

  • 30017531

Additional Document Info

volume

  • 24

issue

  • 9