TREX1 dictates the immune fate of irradiated cancer cells. Academic Article uri icon

Overview

abstract

  • The optimal radiation dose and fractionation to induce anti-tumor immunity remain elusive. We recently found that the exonuclease TREX1 abrogates the immunogenicity of irradiated cancer cells by degrading interferon-stimulatory cytosolic dsDNA. TREX1 upregulation by radiation dose per fraction beyond a threshold of 10-12 Gy results in poor synergy with immune checkpoint blockers.

publication date

  • June 16, 2017

Identity

PubMed Central ID

  • PMC5599078

Scopus Document Identifier

  • 85028557564

Digital Object Identifier (DOI)

  • 10.1080/2162402X.2017.1339857

PubMed ID

  • 28932642

Additional Document Info

volume

  • 6

issue

  • 9