Claire I Vanpouille-Box   Assistant Professor of Cell Biology in Radiation Oncology

Claire Vanpouille-Box is an Assistant Professor of Cell Biology in Radiation Oncology. She developed a keen interest in anti-cancer treatments based on the combination of immunotherapy and radiation therapy (RT). Her graduate work at the University of Angers (France), studied a new treatment concept that aims at generating a localized RT via the use of nanoparticles during which she became interested in radiation-induced anti-tumor immunity. 

She then conducted her postdoctoral training  at NYU School of Medicine and at Weill Cornell Medicine whose preclinical studies demonstrated that TGFb is a master regulator of RT-induced anti-tumor immunity and that RT-induced cancer-cell type I interferon is required to elicit durable regression of the irradiated and non-irradiated tumor (i.e., the abscopal effect). 

Claire has received many prestigious awards among which the 2014-Marie Curie Award from the Radiation Research Society (RRS) and the 2015-AACR Susan G Komen Scholar-in-training award from the American Association for Cancer Research (AACR). 

She serves as associate editor for the Journal of Translational Medicine and Radiation Research. 

  • The main focus of her group is to investigate the key factors impacting the immunogenicity of radiotherapy in brain malignancies. More specifically, the Vanpouille-Box lab aims at exploring the immune-metabolic role of radiation therapy and to define the impact of TGF-beta and activin A in the radiation response of glioblastomas. With a better understanding of the metabolic changes, molecular pathways and cellular responses from the host and/or the tumor that result from radiation therapy, our main goal is to identify new actionable targets for the modulation of anti-tumor immune responses against glioblastomas.

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Contact

full name

  • Claire I Vanpouille-Box

primary email

  • clv2002@med.cornell.edu