Cytosolic DNA Sensing in Organismal Tumor Control. Review uri icon



  • Besides constituting a first layer of defense against microbial challenges, the detection of cytosolic DNA is fundamental for mammalian organisms to control malignant transformation and tumor progression. The accumulation of DNA in the cytoplasm can initiate the proliferative inactivation (via cellular senescence) or elimination (via regulated cell death) of neoplastic cell precursors. Moreover, cytosolic DNA sensing is intimately connected to the secretion of cytokines that support innate and adaptive antitumor immunity. Here, we discuss the molecular mechanisms whereby cytosolic DNA enables cell-intrinsic and -extrinsic oncosuppression, and their relevance for the development of novel therapeutic approaches that reinstate anticancer immunosurveillance.

publication date

  • June 28, 2018



  • Cell Transformation, Neoplastic
  • Cytosol
  • DNA
  • Immunologic Surveillance
  • Neoplasms


Scopus Document Identifier

  • 85048439930

Digital Object Identifier (DOI)

  • 10.1016/j.ccell.2018.05.013

PubMed ID

  • 30216189

Additional Document Info


  • 34


  • 3