Adaptive inhibition of CGAS signaling by TREX1. Academic Article uri icon

Overview

abstract

  • Mammalian cells react to the accumulation of double-stranded (ds)DNA in the cytosol by secreting antiviral and proinflammatory cytokines, notably type I interferon (IFN). Recent data reported by Tani et al. demonstrate that overactivation of this pathway is prevented by an adaptive feedback mechanism elicited by type I IFN receptors and executed by the exonuclease three prime repair exonuclease 1 (TREX1).

publication date

  • February 13, 2024

Research

keywords

  • Cytokines
  • Exodeoxyribonucleases
  • Phosphoproteins

Identity

Digital Object Identifier (DOI)

  • 10.1016/j.trecan.2024.02.001

PubMed ID

  • 38355355