Detection and quantification of cytosolic DNA. uri icon

Overview

abstract

  • Cytosolic DNA sensing is emerging to be a critical component of the antitumor immune response by jumpstarting innate immune responses subsequent to the stimulation of the cGAS and STING pathway. Investigating the accumulation of DNA species in the cytosol is therefore an essential readout for promising anticancer strategies. In this chapter, we present different techniques that can be utilized to detect and quantify cytosolic DNA accumulation.

publication date

  • August 9, 2019

Research

keywords

  • Cytosol
  • DNA
  • Immunity, Innate
  • Neoplasms

Identity

Scopus Document Identifier

  • 85070188968

Digital Object Identifier (DOI)

  • 10.1016/bs.mie.2019.07.042

PubMed ID

  • 31727239

Additional Document Info

volume

  • 629