Harnessing FLASH irradiation to improve immunotherapy of medulloblastoma. Academic Article uri icon

Overview

abstract

  • Ultra-high dose delivery of radiation (>40 Gy/s), namely FLASH radiation therapy (FLASH-RT), is a novel treatment strategy that maximizes cell kill while sparing normal tissue. Recent data reported by Ni et al. demonstrate that one of the mechanisms through which FLASH-RT promotes inflammation involves the metabolic reprogramming of macrophages to support immune stimulation, thus enhancing immunotherapy in medulloblastoma (MB).

publication date

  • March 6, 2025

Identity

Digital Object Identifier (DOI)

  • 10.1016/j.trecan.2025.02.005

PubMed ID

  • 40055118