Pharmacological modulation of nucleic acid sensors - therapeutic potential and persisting obstacles. Review uri icon



  • Nucleic acid sensors, primarily TLR and RLR family members, as well as cGAS-STING signalling, play a critical role in the preservation of cellular and organismal homeostasis. Accordingly, deregulated nucleic acid sensing contributes to the origin of a diverse range of disorders, including infectious diseases, as well as cardiovascular, autoimmune and neoplastic conditions. Accumulating evidence indicates that normalizing aberrant nucleic acid sensing can mediate robust therapeutic effects. However, targeting nucleic acid sensors with pharmacological agents, such as STING agonists, presents multiple obstacles, including drug-, target-, disease- and host-related issues. Here, we discuss preclinical and clinical data supporting the potential of this therapeutic paradigm and highlight key limitations and possible strategies to overcome them.

publication date

  • September 25, 2019



  • Antineoplastic Agents
  • Cancer Vaccines
  • Immunity, Innate
  • Immunotherapy
  • Neoplasms
  • Nucleic Acids


Scopus Document Identifier

  • 85074242543

Digital Object Identifier (DOI)

  • 10.1038/s41573-019-0043-2

PubMed ID

  • 31554927

Additional Document Info


  • 18


  • 11