Molecular genotypes of the human T cell receptor gamma-chain. Academic Article uri icon

Overview

abstract

  • New RFLP of the human TCR gamma-chain defined by a single restriction enzyme (PvuII) are described. They define three alleles and allow haplotype assignments within families. They occur at a high frequency within the population studied and are useful for studies on disease associations with the gamma-chain genes. The PvuII sites flank the C gamma 2 gene. A polymorphic site maps to an area 0.5 kb downstream of C gamma 2-exon III. The second RFLP appears to be the result of a 3-kb insertion giving rise to differences in the number of copies of exon II in the C gamma 2 gene.

publication date

  • February 15, 1988

Research

keywords

  • Deoxyribonucleases, Type II Site-Specific
  • Receptors, Antigen, T-Cell

Identity

Scopus Document Identifier

  • 0023837241

PubMed ID

  • 2893827

Additional Document Info

volume

  • 140

issue

  • 4