Adiposity, Inflammation, and Breast Cancer Pathogenesis in Asian Women. Academic Article uri icon

Overview

abstract

  • Obesity is associated with white adipose tissue (WAT) inflammation in the breast, elevated levels of the estrogen biosynthetic enzyme, aromatase, and systemic changes that predispose to breast cancer development. We examined whether WAT inflammation and its associated systemic effects correlate with body fat levels in an Asian population where body mass index (BMI) is not an accurate assessment of obesity and cancer risk. We also investigated whether biologic differences could account for the greater proportion of premenopausal estrogen receptor (ER)-positive breast cancer in Asian versus Western countries. Breast WAT and fasting blood were prospectively collected from Taiwanese women undergoing mastectomy for breast cancer treatment. Body composition was measured in a subgroup using bioelectrical impedance analysis. WAT inflammation was defined by the presence of crown-like structures of the breast, which are composed of dead or dying adipocytes surrounded by macrophages. Findings were compared with U.S. Caucasian women. In the Taiwanese cohort (n = 72), breast WAT inflammation was present in 31 (43%) women and was associated with elevated BMI (P < 0.01) and increased levels of body fat (P < 0.01), C-reactive protein (P = 0.02), triglycerides (P < 0.01), insulin resistance scores (P = 0.04), and lower HDL cholesterol (P < 0.01). ER+ tumors were associated with greater body fat versus other subtypes (P = 0.03). Compared with U.S. Caucasians (n = 267), Taiwanese women had larger breast adipocytes despite lower BMI after adjusting for BMI and menopausal status (P = 0.01). A subclinical inflammatory state associated with increased adiposity and metabolic dysfunction could contribute to breast cancer pathogenesis in Asian women. Cancer Prev Res; 11(4); 227-36. ©2017 AACR.

publication date

  • December 8, 2017

Research

keywords

  • Adipose Tissue, White
  • Adiposity
  • Asian Continental Ancestry Group
  • Asian People
  • Asians
  • European Continental Ancestry Group
  • Inflammation
  • Triple Negative Breast Neoplasms
  • White People
  • Whites

Identity

PubMed Central ID

  • PMC5882588

Scopus Document Identifier

  • 85047775239

Digital Object Identifier (DOI)

  • 10.1158/1940-6207.CAPR-17-0283

PubMed ID

  • 29222346

Additional Document Info

volume

  • 11

issue

  • 4