Zhou, Xi Kathy

Publications

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Co-Author Network

selected publications

Impact of radiotherapy dose, fractionation and immunotherapeutic partner in a mouse model of HR+ mammary carcinogenesis. Journal of the National Cancer Institute. 2024 Academic Article GET IT
Postlumpectomy Mammography for Management of Breast Cancers With Microcalcifications. JAMA surgery. 2024 Academic Article GET IT
Inhibition of UVB radiation-induced tissue swelling and immune suppression by nicotinamide riboside and pterostilbene. Photodermatology, photoimmunology & photomedicine. 2024 Academic Article GET IT
Disaggregating the Asian-American Breast Cancer Population: Disparities in Reconstruction Rates. The Journal of surgical research. 2024 Academic Article GET IT
Outcomes of atypical lobular hyperplasia managed by active surveillance or immediate surgery. World journal of surgery. 2024 Academic Article GET IT
Breast Cancer Incidence Among Asian American Women in New York City: Disparities in Screening and Presentation. Annals of surgical oncology. 2023 Academic Article GET IT
A randomized phase II trial of MR-guided prostate stereotactic body radiotherapy administered in 5 or 2 fractions for localized prostate cancer (FORT). BMC cancer. 2023 Academic Article GET IT
Neoadjuvant botensilimab plus balstilimab response pattern in locally advanced mismatch repair proficient colorectal cancer. Oncogene. 2023 Academic Article GET IT
Immunotherapy targeting different immune compartments in combination with radiation therapy induces regression of resistant tumors. Nature communications. 2023 Academic Article GET IT
Randomized phase II trial of MRI-guided salvage radiotherapy for prostate cancer in 4 weeks versus 2 weeks (SHORTER). BMC cancer. 2023 Academic Article GET IT
Obesity promotes breast epithelium DNA damage in women carrying a germline mutation in BRCA1 or BRCA2. Science translational medicine. 2023 Academic Article GET IT
Times cited: 1
Cellular senescence in the response of HR⁺ breast cancer to radiotherapy and CDK4/6 inhibitors. Journal of translational medicine. 2023 Academic Article GET IT
Microbes Contribute to Chemopreventive Efficacy, Intestinal Tumorigenesis and the Metabolome. Cancer prevention research (Philadelphia, Pa.). 2022 Academic Article GET IT
Expression of the mono-ADP-ribosyltransferase ART1 by tumor cells mediates immune resistance in non-small cell lung cancer. Science translational medicine. 2022 Academic Article GET IT
Increased trunk fat is associated with altered gene expression in breast tissue of normal weight women. NPJ breast cancer. 2022 Academic Article GET IT
Regulation of Cutaneous Immunity In Vivo by Calcitonin Gene-Related Peptide Signaling through Endothelial Cells. Journal of immunology (Baltimore, Md. : 1950). 2022 Academic Article GET IT
Reciprocal impacts of telomerase activity and ADRN/MES differentiation state in neuroblastoma tumor biology. Communications biology. 2021 Academic Article GET IT
LTX-315-enabled, radiotherapy-boosted immunotherapeutic control of breast cancer by NK cells. Oncoimmunology. 2021 Academic Article GET IT
Blood Biomarkers Reflect the Effects of Obesity and Inflammation on the Human Breast Transcriptome. Carcinogenesis. 2021 Academic Article GET IT
Dietary interventions to prevent high-fructose diet-associated worsening of colitis and colitis-associated tumorigenesis in mice. Carcinogenesis. 2021 Academic Article GET IT
Times cited: 18
GLUT5 is a determinant of dietary fructose-mediated exacerbation of experimental colitis. American journal of physiology. Gastrointestinal and liver physiology. 2021 Academic Article GET IT
Times cited: 1
Anti-tumor effects of an ID antagonist with no observed acquired resistance. NPJ breast cancer. 2021 Academic Article GET IT
Effects of Adiposity and Exercise on Breast Tissue and Systemic Metabo-Inflammatory Factors in Women at High Risk or Diagnosed with Breast Cancer. Cancer prevention research (Philadelphia, Pa.). 2021 Academic Article GET IT
Effects of obesity on breast aromatase expression and systemic metabo-inflammation in women with BRCA1 or BRCA2 mutations. NPJ breast cancer. 2021 Academic Article GET IT
Times cited: 7
Radiotherapy-exposed CD8+ and CD4+ neoantigens enhance tumor control. The Journal of clinical investigation. 2021 Academic Article GET IT
Times cited: 141
Exogenous and Endogenous Sources of Serine Contribute to Colon Cancer Metabolism, Growth, and Resistance to 5-Fluorouracil. Cancer research. 2021 Academic Article GET IT
Times cited: 73
Dietary Fructose Alters the Composition, Localization, and Metabolism of Gut Microbiota in Association With Worsening Colitis. Cellular and molecular gastroenterology and hepatology. 2020 Academic Article GET IT
Times cited: 69
Obesity is Associated with Worse Outcomes in COVID-19: Analysis of Early Data from New York City. Obesity (Silver Spring, Md.). 2020 Academic Article GET IT
Times cited: 151
CD73 Blockade Promotes Dendritic Cell Infiltration of Irradiated Tumors and Tumor Rejection. Cancer immunology research. 2020 Academic Article GET IT
Times cited: 102
Supplemental estrogen and caloric restriction reduce obesity-induced periprostatic white adipose inflammation in mice. Carcinogenesis. 2019 Academic Article GET IT
Times cited: 14
Obesity-Associated Extracellular Matrix Remodeling Promotes a Macrophage Phenotype Similar to Tumor-Associated Macrophages. The American journal of pathology. 2019 Academic Article GET IT
Times cited: 64
Prostaglandin E₂ down-regulates sirtuin 1 (SIRT1), leading to elevated levels of aromatase, providing insights into the obesity-breast cancer connection. The Journal of biological chemistry. 2018 Academic Article GET IT
Times cited: 20
Obesity-associated Breast Inflammation among Hispanic/Latina Breast Cancer Patients. Cancer prevention research (Philadelphia, Pa.). 2018 Academic Article GET IT
Times cited: 12
Radiotherapy induces responses of lung cancer to CTLA-4 blockade. Nature medicine. 2018 Academic Article GET IT
Times cited: 691
Colonoscopic-Guided Pinch Biopsies in Mice as a Useful Model for Evaluating the Roles of Host and Luminal Factors in Colonic Inflammation. The American journal of pathology. 2018 Academic Article GET IT
Times cited: 3
FGFR1 underlies obesity-associated progression of estrogen receptor-positive breast cancer after estrogen deprivation. JCI insight. 2018 Academic Article GET IT
Times cited: 38
Gastric Carcinomas With Lymphoid Stroma: An Evaluation of the Histopathologic and Molecular Features. The American journal of surgical pathology. 2018 Academic Article GET IT
Times cited: 17
A Randomized Multicenter Phase II Study of Docosahexaenoic Acid in Patients with a History of Breast Cancer, Premalignant Lesions, or Benign Breast Disease. Cancer prevention research (Philadelphia, Pa.). 2018 Academic Article GET IT
Times cited: 19
Regulation of T helper cell responses during antigen presentation by norepinephrine-exposed endothelial cells. Immunology. 2017 Academic Article GET IT
Times cited: 7
Adiposity, Inflammation, and Breast Cancer Pathogenesis in Asian Women. Cancer prevention research (Philadelphia, Pa.). 2017 Academic Article GET IT
Times cited: 36
Pioglitazone Inhibits Periprostatic White Adipose Tissue Inflammation in Obese Mice. Cancer prevention research (Philadelphia, Pa.). 2017 Academic Article GET IT
Times cited: 20
Leptin regulation of the p53-HIF1α/PKM2-aromatase axis in breast adipose stromal cells: a novel mechanism for the obesity-breast cancer link. International journal of obesity (2005). 2017 Academic Article GET IT
Times cited: 52
A single-operator learning curve analysis for the endoscopic sleeve gastroplasty. Gastrointestinal endoscopy. 2017 Academic Article GET IT
Times cited: 39
Periprostatic adipose inflammation is associated with high-grade prostate cancer. Prostate cancer and prostatic diseases. 2017 Academic Article GET IT
Times cited: 66
Menopause Is a Determinant of Breast Aromatase Expression and Its Associations With BMI, Inflammation, and Systemic Markers. The Journal of clinical endocrinology and metabolism. 2017 Academic Article GET IT
Times cited: 80
Effects of Rapid Weight Loss on Systemic and Adipose Tissue Inflammation and Metabolism in Obese Postmenopausal Women. Journal of the Endocrine Society. 2017 Academic Article GET IT
Times cited: 58
Metabolic Obesity, Adipose Inflammation and Elevated Breast Aromatase in Women with Normal Body Mass Index. Cancer prevention research (Philadelphia, Pa.). 2017 Academic Article GET IT
Times cited: 121
IgA-coated E. coli enriched in Crohn's disease spondyloarthritis promote T_H17-dependent inflammation. Science translational medicine. 2017 Academic Article GET IT
Times cited: 232
White adipose tissue inflammation and cancer-specific survival in patients with squamous cell carcinoma of the oral tongue. Cancer. 2016 Academic Article GET IT
Times cited: 41
Celecoxib Alters the Intestinal Microbiota and Metabolome in Association with Reducing Polyp Burden. Cancer prevention research (Philadelphia, Pa.). 2016 Academic Article GET IT
Times cited: 34
Elevated Levels of Urinary PGE-M Are Found in Tobacco Users and Indicate a Poor Prognosis for Oral Squamous Cell Carcinoma Patients. Cancer prevention research (Philadelphia, Pa.). 2016 Academic Article GET IT
Times cited: 4
Early human herpes virus type 6 reactivation in umbilical cord blood allogeneic stem cell transplantation. Leukemia & lymphoma. 2016 Academic Article GET IT
Times cited: 10
Allogeneic Transplantation for Patients With Advanced Myelofibrosis: Splenomegaly and High Serum LDH are Adverse Risk Factors for Successful Engraftment. Clinical lymphoma, myeloma & leukemia. 2016 Academic Article GET IT
Times cited: 10
Calcitonin Gene-Related Peptide-Exposed Endothelial Cells Bias Antigen Presentation to CD4+ T Cells toward a Th17 Response. Journal of immunology (Baltimore, Md. : 1950). 2016 Academic Article GET IT
Times cited: 30
Noninvasive Detection of Inflammatory Changes in White Adipose Tissue by Label-Free Raman Spectroscopy. Analytical chemistry. 2016 Academic Article GET IT
Times cited: 20
Systemic Correlates of White Adipose Tissue Inflammation in Early-Stage Breast Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2015 Academic Article GET IT
Times cited: 157
Id1 expression in endothelial cells of the colon is required for normal response to injury. The American journal of pathology. 2015 Academic Article GET IT
Times cited: 9
Obesity-dependent changes in interstitial ECM mechanics promote breast tumorigenesis. Science translational medicine. 2015 Academic Article GET IT
Times cited: 236
Estrogen Protects against Obesity-Induced Mammary Gland Inflammation in Mice. Cancer prevention research (Philadelphia, Pa.). 2015 Academic Article GET IT
Times cited: 29
Comprehensive models of human primary and metastatic colorectal tumors in immunodeficient and immunocompetent mice by chemokine targeting. Nature biotechnology. 2015 Academic Article GET IT
Times cited: 27
Menopause is a determinant of breast adipose inflammation. Cancer prevention research (Philadelphia, Pa.). 2015 Academic Article GET IT
Times cited: 84
Id1 Deficiency Protects against Tumor Formation in Apc(Min/+) Mice but Not in a Mouse Model of Colitis-Associated Colon Cancer. Cancer prevention research (Philadelphia, Pa.). 2015 Academic Article GET IT
Times cited: 8
ID1 is a functional marker for intestinal stem and progenitor cells required for normal response to injury. Stem cell reports. 2014 Academic Article GET IT
Times cited: 36
Tobacco smoke-induced immunologic changes may contribute to oral carcinogenesis. Journal of investigative medicine : the official publication of the American Federation for Clinical Research. 2014 Academic Article GET IT
Times cited: 13
Impact of obesity on the survival of patients with early-stage squamous cell carcinoma of the oral tongue. Cancer. 2014 Academic Article GET IT
Times cited: 59
Rapid-Testing Technology and Systems Improvement for the Elimination of Congenital Syphilis in Haiti: Overcoming the "Technology to Systems Gap". Journal of sexually transmitted diseases. 2013 Academic Article GET IT
Norepinephrine and adenosine-5'-triphosphate synergize in inducing IL-6 production by human dermal microvascular endothelial cells. Cytokine. 2013 Academic Article GET IT
Times cited: 34
Dietary polyphenols suppress elevated levels of proinflammatory mediators and aromatase in the mammary gland of obese mice. Cancer prevention research (Philadelphia, Pa.). 2013 Academic Article GET IT
Times cited: 35
Effect of zileuton and celecoxib on urinary LTE4 and PGE-M levels in smokers. Cancer prevention research (Philadelphia, Pa.). 2013 Academic Article GET IT
Times cited: 21
Genetic deletion of microsomal prostaglandin E synthase-1 suppresses mouse mammary tumor growth and angiogenesis. Prostaglandins & other lipid mediators. 2013 Academic Article GET IT
Times cited: 26
Immunohistochemical stains for CD3 and CD8 do not improve detection of gluten-sensitive enteropathy in duodenal biopsies. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 2013 Academic Article GET IT
Times cited: 17
Increased levels of urinary PGE-M, a biomarker of inflammation, occur in association with obesity, aging, and lung metastases in patients with breast cancer. Cancer prevention research (Philadelphia, Pa.). 2013 Academic Article GET IT
Times cited: 61
Caloric restriction reverses obesity-induced mammary gland inflammation in mice. Cancer prevention research (Philadelphia, Pa.). 2013 Academic Article GET IT
Times cited: 48
S1P₁ localizes to the colonic vasculature in ulcerative colitis and maintains blood vessel integrity. Journal of lipid research. 2013 Academic Article GET IT
Times cited: 56
Metabolic profiling, a noninvasive approach for the detection of experimental colorectal neoplasia. Cancer prevention research (Philadelphia, Pa.). 2012 Academic Article GET IT
Times cited: 46
N-acetyl-S-farnesyl-l-cysteine suppresses chemokine production by human dermal microvascular endothelial cells. Experimental dermatology. 2012 Academic Article GET IT
Times cited: 5
Pioglitazone, a PPARγ agonist, suppresses CYP19 transcription: evidence for involvement of 15-hydroxyprostaglandin dehydrogenase and BRCA1. Cancer prevention research (Philadelphia, Pa.). 2012 Academic Article GET IT
Times cited: 24
A web-based screening and accrual strategy for a cancer prevention clinical trial in healthy smokers. Contemporary clinical trials. 2012 Academic Article GET IT
Times cited: 14
MicroRNA expression aids the preoperative diagnosis of pancreatic ductal adenocarcinoma. Pancreas. 2012 Academic Article GET IT
Times cited: 53
Pituitary adenylate cyclase-activating peptide and vasoactive intestinal polypeptide bias Langerhans cell Ag presentation toward Th17 cells. European journal of immunology. 2012 Academic Article GET IT
Times cited: 29
Activation status of Wnt/ß-catenin signaling in normal and neoplastic breast tissues: relationship to HER2/neu expression in human and mouse. PloS one. 2012 Academic Article GET IT
Times cited: 46
Increased levels of COX-2 and prostaglandin E2 contribute to elevated aromatase expression in inflamed breast tissue of obese women. Cancer discovery. 2012 Academic Article GET IT
Times cited: 220
The effect of HIV and HPV coinfection on cervical COX-2 expression and systemic prostaglandin E2 levels. Cancer prevention research (Philadelphia, Pa.). 2011 Academic Article GET IT
Times cited: 37
Biologic phenotyping of the human small airway epithelial response to cigarette smoking. PloS one. 2011 Academic Article GET IT
Times cited: 63
Taxane-induced blockade to nuclear accumulation of the androgen receptor predicts clinical responses in metastatic prostate cancer. Cancer research. 2011 Academic Article GET IT
Times cited: 379
Inflammation and increased aromatase expression occur in the breast tissue of obese women with breast cancer. Cancer prevention research (Philadelphia, Pa.). 2011 Academic Article GET IT
Times cited: 390
Multiple cancer/testis antigens are preferentially expressed in hormone-receptor negative and high-grade breast cancers. PloS one. 2011 Academic Article GET IT
Times cited: 83
Obesity is associated with inflammation and elevated aromatase expression in the mouse mammary gland. Cancer prevention research (Philadelphia, Pa.). 2011 Academic Article GET IT
Times cited: 334
Calcitonin gene-related peptide inhibits chemokine production by human dermal microvascular endothelial cells. Brain, behavior, and immunity. 2011 Academic Article GET IT
Times cited: 48
Clinical and biologic importance of F-actin autoantibodies in HCV monoinfected and HCV-HIV coinfected patients. American journal of clinical pathology. 2010 Academic Article GET IT
Times cited: 4
Effects of cigarette smoke on the human oral mucosal transcriptome. Cancer prevention research (Philadelphia, Pa.). 2010 Academic Article GET IT
Times cited: 145
Maitake beta-glucan promotes recovery of leukocytes and myeloid cell function in peripheral blood from paclitaxel hematotoxicity. Cancer immunology, immunotherapy : CII. 2010 Academic Article GET IT
Times cited: 16
Elevated levels of urinary prostaglandin e metabolite indicate a poor prognosis in ever smoker head and neck squamous cell carcinoma patients. Cancer prevention research (Philadelphia, Pa.). 2009 Academic Article GET IT
Times cited: 21
Clinical, pathologic, and molecular features of early-onset colorectal carcinoma. The American journal of surgical pathology. 2009 Academic Article GET IT
Times cited: 121
Levels of prostaglandin E metabolite and leukotriene E(4) are increased in the urine of smokers: evidence that celecoxib shunts arachidonic acid into the 5-lipoxygenase pathway. Cancer prevention research (Philadelphia, Pa.). 2009 Academic Article GET IT
Times cited: 100
Phosphorylated 4E-BP1 is associated with poor survival in melanoma. Clinical cancer research : an official journal of the American Association for Cancer Research. 2009 Academic Article GET IT
Times cited: 58
Maitake beta-glucan enhances umbilical cord blood stem cell transplantation in the NOD/SCID mouse. Experimental biology and medicine (Maywood, N.J.). 2009 Academic Article GET IT
Times cited: 12
Distinct specificities of Mycobacterium tuberculosis and mammalian proteasomes for N-acetyl tripeptide substrates. The Journal of biological chemistry. 2008 Academic Article GET IT
Times cited: 48
Combination chemoprevention of HER2/neu-induced breast cancer using a cyclooxygenase-2 inhibitor and a retinoid X receptor-selective retinoid. Cancer prevention research (Philadelphia, Pa.). 2008 Academic Article GET IT
Times cited: 36
Total number of resected lymph nodes predicts survival in esophageal cancer. Annals of surgery. 2008 Academic Article GET IT
Times cited: 209
MicroRNA analysis as a potential diagnostic tool for papillary thyroid carcinoma. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 2008 Academic Article GET IT
Times cited: 174
Survivin as a useful adjunct marker for the grading of papillary urothelial carcinoma. Archives of pathology & laboratory medicine. 2008 Academic Article GET IT
Times cited: 26
Clinical relevance of neutral endopeptidase (NEP/CD10) in melanoma. Journal of translational medicine. 2007 Academic Article GET IT
Times cited: 28
Potentially reduced exposure cigarettes accelerate atherosclerosis: evidence for the role of nicotine. Cardiovascular toxicology. 2007 Academic Article GET IT
Times cited: 36
Some design issues of strata-matched non-randomized studies with survival outcomes. Statistics in medicine. 2006 Academic Article GET IT
Gene expression profiling separates chromophobe renal cell carcinoma from oncocytoma and identifies vesicular transport and cell junction proteins as differentially expressed genes. Clinical cancer research : an official journal of the American Association for Cancer Research. 2006 Academic Article GET IT
Times cited: 62
Do competence skills moderate the impact of social influences to drink and perceived social benefits of drinking on alcohol use among inner-city adolescents?. Prevention science : the official journal of the Society for Prevention Research. 2006 Academic Article GET IT
Times cited: 18
Messenger RNA expression ratios among four genes predict subtypes of renal cell carcinoma and distinguish oncocytoma from carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research. 2005 Academic Article GET IT
Times cited: 38
Classification of Missense Mutations of Disease Genes. Journal of the American Statistical Association. 2005 Academic Article GET IT
Expression of the mono-ADP-ribosyltransferase ART1 by tumor cells mediates immune resistance in non-small cell lung cancer. Academic Article
Expression of the mono-ADP-ribosyltransferase ART1 by tumor cells mediates immune resistance in non-small cell lung cancer. Academic Article
Expression of the mono-ADP-ribosyltransferase ART1 by tumor cells mediates immune resistance in non-small cell lung cancer. Academic Article
Expression of the mono-ADP-ribosyltransferase ART1 by tumor cells mediates immune resistance in non-small cell lung cancer. Academic Article
Expression of the mono-ADP-ribosyltransferase ART1 by tumor cells mediates immune resistance in non-small cell lung cancer. Academic Article
Expression of the mono-ADP-ribosyltransferase ART1 by tumor cells mediates immune resistance in non-small cell lung cancer. Academic Article
Regulation of Cutaneous Immunity In Vivo by Calcitonin Gene-Related Peptide Signaling through Endothelial Cells. J Immunol. J Immunol. Academic Article

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Research

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Co-investigator Network

Funding awarded

Application of 4D proteomics and super-resolution microscopy in extracellular vesicle and particle-borne biomarker discovery for early pancreatic cancer detection awarded by National Cancer Institute Co-Investigator 2023 - 2028
Targeting the BCL2 immune checkpoint to enhance the immunostimulatory effects of radiation in breast cancer awarded by National Cancer Institute Co-Investigator 2023 - 2028
Fatty acid metabolic regulation of anti-tumor immunity against irradiated glioblastoma awarded by National Institute of Neurological Disorders & Stroke Co-Investigator 2023 - 2028
Microbiota, Metabolites, and Colon Neoplasia awarded by National Cancer Institute Co-Investigator 2021 - 2026
Correlative biomarkers to optimize breast cancer treatment and prevention strategies awarded by Breast Cancer Research Foundation, Inc. Co-Investigator 2024 - 2025
Role of FAP-positive cells in immune response to irradiated glioblastoma awarded by National Cancer Institute Co-Investigator 2023 - 2025
Development of novel preclinical models and therapeutics for ETMR awarded by Children''s Cancer Research Fund Co-Investigator 2023 - 2025
Extending the survival of HR+ breast cancer patients receiving CDK4/6 inhibitors by targeting IL17-producing gamma delta T cells awarded by United States Department of Defense Co-Investigator 2022 - 2025
Defining the role of stress-induced changes in the IgG-gut microbiomeneutrophil axis during breast cancer progression and metastasis awarded by Starr Cancer Consortium Co-Investigator 2023 - 2024
Elucidating the Role of MALAT1 Somatic Driver Mutations in Colorectal Cancer awarded by National Cancer Institute Co-Investigator 2018 - 2024
missing activity Co-Investigator 2018 - 2024
missing activity Co-Investigator 2018 - 2024

Dissecting the interplay between immunoglobulin G and the gut microbiome in cancer progression and metastasis awarded by National Cancer Institute Co-Principal Investigator 2023 - 2024

Cancer Cell Intrinsic Interferon-I pathway Activation by Fractionated Radiation awarded by National Cancer Institute Key Personnel 2022 - 2027
Correlative biomarkers to optimize breast cancer treatment and prevention strategies awarded by Breast Cancer Research Foundation, Inc. Key Personnel 2024 - 2025
Optimization of immune checkpoint inhibition during radiation-induced vaccination in breast cancer awarded by Breast Cancer Research Foundation, Inc. Key Personnel 2023 - 2024
missing activity Key Personnel 2021 - 2023

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Background

education and training

B.S., Nanjing University (China) 96
Ph.D., Duke University 2002
M.S., Duke University 2000

Contact

full name

Xi Kathy Zhou

primary email

kaz2004@med.cornell.edu

VIVO Weill Cornell Medical College

Xi Kathy Zhou Professor of Research in Population Health Sciences

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email