α-Emitters for Radiotherapy: From Basic Radiochemistry to Clinical Studies-Part 2. Review uri icon

Overview

abstract

  • The use of radioactive sources to deliver cytotoxic ionizing radiation to disease sites dates back to the early 20th century, with the discovery of radium and its physiologic effects. α-emitters are of particular interest in the field of clinical oncology for radiotherapy applications. The first part of this review explored the basic radiochemistry, high cell-killing potency, and availability of α-emitting radionuclides, together with hurdles such as radiolabeling methods and daughter redistribution. The second part of this review will give an overview of the most promising and current uses of α-emitters in preclinical and clinical studies.

publication date

  • March 1, 2018

Research

keywords

  • Alpha Particles
  • Radiochemistry
  • Translational Medical Research
  • Translational Research, Biomedical

Identity

PubMed Central ID

  • PMC6910645

Scopus Document Identifier

  • 85049404512

Digital Object Identifier (DOI)

  • 10.2967/jnumed.117.204651

PubMed ID

  • 29496984

Additional Document Info

volume

  • 59

issue

  • 7