The Evolving Landscape of Brain Metastasis. Review uri icon

Overview

abstract

  • Metastasis, involving the spread of systemic cancer to the brain, results in neurologic disability and death. Current treatments are largely palliative in nature; improved therapeutic approaches represent an unmet clinical need. However, recent experimental and clinical advances challenge the bleak long-term outcome of this disease. Encompassing key recent findings in epidemiology, genetics, microenvironment, leptomeningeal disease, neurocognition, targeted therapy, immunotherapy, and prophylaxis, we review preclinical and clinical studies to provide a comprehensive picture of contemporary research and the management of secondary brain tumors.

publication date

  • February 21, 2018

Research

keywords

  • Brain Neoplasms

Identity

PubMed Central ID

  • PMC6602095

Scopus Document Identifier

  • 85042190508

Digital Object Identifier (DOI)

  • 10.1016/j.trecan.2018.01.003

PubMed ID

  • 29506669

Additional Document Info

volume

  • 4

issue

  • 3