BAX and BAK at the Gates of Innate Immunity. Article uri icon

Overview

abstract

  • Large BAX/BAK pores that form during apoptosis enable mitochondrial nucleoids to access the cytosol, potentially leading to inflammatory signaling via CGAS. Under physiological conditions, however, BAX/BAK-dependent caspase activation rapidly dismantles dying cells to prevent inflammatory responses. BAX and BAK operate at the interface between apoptotic signaling and innate immunity control.

publication date

  • March 16, 2018

Research

keywords

  • DNA, Mitochondrial
  • bcl-2-Associated X Protein

Identity

Scopus Document Identifier

  • 85043984520

Digital Object Identifier (DOI)

  • 10.1016/j.tcb.2018.02.010

PubMed ID

  • 29555208

Additional Document Info

volume

  • 28

issue

  • 5