Clinical Potential of Human Epidermal Growth Factor Receptor 2 and Human Epidermal Growth Factor Receptor 3 Imaging in Breast Cancer. Review uri icon

Overview

abstract

  • Increased expression of the human epidermal growth factor receptor (HER) protein family are targets in breast cancer for imaging and therapy. Imaging modalities targeting HER2 and HER3 can diagnose breast cancer with a specific, biologically relevant target. Repeat biopsies do not address heterogeneity intratumorally or between primary disease and metastasis. HER2- and HER3-targeted PET is an important tool to diagnose disease in breast cancer and evaluate response to targeted therapies. PET and single photon emission computed tomography with radiolabeled biomolecules can be used to detect and quantify specific targets, conferring a better understanding of the behavior and effectiveness of treatments.

publication date

  • July 1, 2018

Research

keywords

  • Breast Neoplasms
  • Positron-Emission Tomography
  • Receptor, ErbB-2
  • Receptor, ErbB-3
  • Tomography, Emission-Computed, Single-Photon

Identity

PubMed Central ID

  • PMC6092024

Scopus Document Identifier

  • 85049344324

Digital Object Identifier (DOI)

  • 10.1016/j.cpet.2018.02.010

PubMed ID

  • 30100080

Additional Document Info

volume

  • 13

issue

  • 3