Emerging translational science discoveries, clonal approaches, and treatment trends in chronic myeloproliferative neoplasms. Review uri icon

Overview

abstract

  • The 60th American Society of Hematology (ASH) held in San Diego in December 2018 was followed by the 13th Post-ASH chronic myeloproliferative neoplasms (MPNs) workshop on December 4 and 5, 2018. This closed annual workshop, first introduced in 2006 by Goldman and Mughal, was organized in collaboration with Alpine Oncology Foundation and allowed experts in preclinical and clinical research in the chronic MPNs to discuss the current scenario, including relevant presentations at ASH, and address pivotal open questions that impact translational research and clinical management. This review is based on the presentations and deliberations at this workshop, and rather than provide a resume of the proceedings, we have selected some of the important translational science and treatment issues that require clarity. We discuss the experimental and observational evidence to support the intimate interaction between aging, inflammation, and clonal evolution of MPNs, the clinical impact of the unfolding mutational landscape on the emerging targets and treatment of MPNs, new methods to detect clonal heterogeneity, the challenges in managing childhood and adolescent MPN, and reflect on the treatment of systemic mastocytosis (SM) following the licensing of midostaurin.

publication date

  • June 20, 2019

Research

keywords

  • Myeloproliferative Disorders
  • Translational Medical Research
  • Translational Research, Biomedical

Identity

Scopus Document Identifier

  • 85068135002

Digital Object Identifier (DOI)

  • 10.1002/hon.2622

PubMed ID

  • 31013548

Additional Document Info

volume

  • 37

issue

  • 3