The regulatory B cell-mediated peripheral tolerance maintained by mast cell IL-5 suppresses oxazolone-induced contact hypersensitivity. Academic Article uri icon

Overview

abstract

  • The function of regulatory immune cells in peripheral tissues is crucial to the onset and severity of various diseases. Interleukin-10 (IL-10)-producing regulatory B (IL-10+ Breg) cells are known to suppress various inflammatory diseases. However, evidence for the mechanism by which IL-10+ Breg cells are generated and maintained is still very limited. Here, we found that IL-10+ Breg cells suppress the activation of IL-13-producing type 2 innate lymphoid cells (IL-13+ ILC2s) in an IL-10-dependent manner in mice with oxazolone-induced severe contact hypersensitivity (CHS). Mast cell (MC) IL-5 was important for maintaining the population of IL-10+ Breg cells in peripheral lymphoid tissues. Overall, these results uncover a previously unknown mechanism of MCs as a type of immunoregulatory cell and elucidate the cross-talk among MCs, IL-10+ Breg cells, and IL-13+ ILC2s in CHS.

publication date

  • July 17, 2019

Research

keywords

  • B-Lymphocytes, Regulatory
  • Dermatitis, Contact
  • Interleukin-5
  • Mast Cells
  • Oxazolone
  • Peripheral Tolerance

Identity

PubMed Central ID

  • PMC6636983

Scopus Document Identifier

  • 85069942253

Digital Object Identifier (DOI)

  • 10.1126/sciadv.aav8152

PubMed ID

  • 31328158

Additional Document Info

volume

  • 5

issue

  • 7