Science advances
Journal
Overview
publication venue for
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CHCHD2 mutant mice link mitochondrial deficits to PD pathophysiology..
11.
2025
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Oligo-CALL: A next-generation barcoding platform for studying resistance to targeted therapy..
11.
2025
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Cooperative role of distinctive TP53 and PTEN combined loss in the peripheral T cell lymphoma-GATA3 molecular subgroup..
11.
2025
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Bordetellae colonization oligosaccharide (b-Cool), a glycan crucial for nasal colonization..
11.
2025
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AKR1B10 dictates c-Myc stability to suppress colorectal cancer metastasis via PP2A nitration..
11.
2025
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Histone acetylation readers Bdf1 and Yaf9 direct SWR1 remodeler to +1 nucleosome..
11.
2025
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GTP hydrolysis triggers membrane remodeling by AMPH-1..
11.
2025
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Ecological interactions and genomic innovation fueled the evolution of ray-finned fish endothermy..
11.
2025
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Senataxin and DNA-PKcs redundantly promote non-homologous end joining repair of DNA double strand breaks during V(D)J recombination..
11.
2025
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Type II kinase inhibitors that target Parkinson's disease-associated LRRK2..
11.
2025
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Rewilding catalyzes maturation of the humoral immune system..
11.
2025
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Gut IgA functionally interacts with systemic IgG to enhance antipneumococcal vaccine responses..
11.
2025
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Vascularization of human islets by adaptable endothelium for durable and functional subcutaneous engraftment..
11.
2025
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Microenvironment actuated CAR T cells improve solid tumor efficacy without toxicity..
11.
2025
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Simultaneous noninvasive quantification of redox and downstream glycolytic fluxes reveals compartmentalized brain metabolism..
10.
2024
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Elevating levels of the endocannabinoid 2-arachidonoylglycerol blunts opioid reward but not analgesia..
10.
2024
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Genomic heterogeneity and ploidy identify patients with intrinsic resistance to PD-1 blockade in metastatic melanoma..
10.
2024
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CalDAG-GEFI acts as a guanine nucleotide exchange factor for LRRK2 to regulate LRRK2 function and neurodegeneration..
10.
2024
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Mouse α-synuclein fibrils are structurally and functionally distinct from human fibrils associated with Lewy body diseases..
10.
2024
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A genetically encoded actuator boosts L-type calcium channel function in diverse physiological settings..
10.
2024
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Small molecules from antibody pharmacophores (SMAbPs) as a hit identification workflow for immune checkpoints..
10.
2024
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Bidirectional regulation of motor circuits using magnetogenetic gene therapy..
10.
2024
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Loss of atrial natriuretic peptide signaling causes insulin resistance, mitochondrial dysfunction, and low endurance capacity..
10.
2024
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ATR inhibition activates cancer cell cGAS/STING-interferon signaling and promotes antitumor immunity in small-cell lung cancer..
10.
2024
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CCR2 cooperativity promotes hematopoietic stem cell homing to the bone marrow..
10.
2024
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CDCA7 is an evolutionarily conserved hemimethylated DNA sensor in eukaryotes..
10.
2024
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Phosphoglycerate kinase is a central leverage point in Parkinson's disease-driven neuronal metabolic deficits..
10.
2024
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Autonomous circadian rhythms in the human hepatocyte regulate hepatic drug metabolism and inflammatory responses..
10.
2024
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PTH treatment before cyclic joint loading improves cartilage health and attenuates load-induced osteoarthritis development in mice..
10.
2024
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A digital twin of the infant microbiome to predict neurodevelopmental deficits..
10.
2024
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Molecular phenotyping of small cell lung cancer using targeted cfDNA profiling of transcriptional regulatory regions..
10.
2024
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Glutamine antagonist DRP-104 suppresses tumor growth and enhances response to checkpoint blockade in KEAP1 mutant lung cancer..
10.
2024
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Childhood cancer mutagenesis caused by transposase-derived PGBD5..
10.
2024
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Redirecting raltitrexed from cancer cell thymidylate synthase to Mycobacterium tuberculosis phosphopantetheinyl transferase..
10.
2024
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Peripheral neural interfaces: Skeletal muscles are hyper-reinnervated according to the axonal capacity of the surgically rewired nerves..
10.
2024
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Distinct beta-arrestin coupling and intracellular trafficking of metabotropic glutamate receptor homo- and heterodimers..
9.
2023
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Inhibition of Parkinson's disease-related LRRK2 by type I and type II kinase inhibitors: Activity and structures..
9.
2023
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History of primary-series and booster vaccination and protection against Omicron reinfection..
9.
2023
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Single-cell genotypic and phenotypic analysis of measurable residual disease in acute myeloid leukemia..
9.
2023
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Artificial intelligence-coupled plasmonic infrared sensor for detection of structural protein biomarkers in neurodegenerative diseases..
9.
2023
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A histone deacetylase 3 and mitochondrial complex I axis regulates toxic formaldehyde production..
9.
2023
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Lighting up metastasis process before formation of secondary tumor by phosphorescence imaging..
9.
2023
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The genetic determinants of recurrent somatic mutations in 43,693 blood genomes..
9.
2023
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Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines..
9.
2023
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An RNA-based system to study hepatitis B virus replication and evaluate antivirals..
9.
2023
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ETV4 mediates dosage-dependent prostate tumor initiation and cooperates with p53 loss to generate prostate cancer..
9.
2023
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Convergent abnormalities in striatal gene networks in human cocaine use disorder and mouse cocaine administration models..
9.
2023
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Optineurin regulates NRF2-mediated antioxidant response in a mouse model of Paget's disease of bone..
9.
2023
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LAMP-enabled diagnosis of Kaposi's sarcoma for sub-Saharan Africa..
9.
2023
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Proteolytic regulation of CD73 by TRIM21 orchestrates tumor immunogenicity..
9.
2023
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A tumor vasculature-based imaging biomarker for predicting response and survival in patients with lung cancer treated with checkpoint inhibitors..
8.
2022
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Control of Gαq signaling dynamics and GPCR cross-talk by GRKs..
8.
2022
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High-temporal resolution profiling reveals distinct immune trajectories following the first and second doses of COVID-19 mRNA vaccines..
8.
2022
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Severe COVID-19 induces autoantibodies against angiotensin II that correlate with blood pressure dysregulation and disease severity..
8.
2022
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Self-assembling peptide nanofiber HIV vaccine elicits robust vaccine-induced antibody functions and modulates Fc glycosylation..
8.
2022
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Molecular architecture of the autoinhibited kinesin-1 lambda particle..
8.
2022
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Disparities in dermatology AI performance on a diverse, curated clinical image set..
8.
2022
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Mitonuclear genotype remodels the metabolic and microenvironmental landscape of Hürthle cell carcinoma..
8.
2022
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Spatial interplay patterns of cancer nuclei and tumor-infiltrating lymphocytes (TILs) predict clinical benefit for immune checkpoint inhibitors..
8.
2022
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Suppression of nuclear GSK3 signaling promotes serine/one-carbon metabolism and confers metabolic vulnerability in lung cancer cells..
8.
2022
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A NAC domain mutation (E83Q) unlocks the pathogenicity of human alpha-synuclein and recapitulates its pathological diversity..
8.
2022
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Ketohexokinase-mediated fructose metabolism is lost in hepatocellular carcinoma and can be leveraged for metabolic imaging..
8.
2022
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Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of indeterminate potential..
8.
2022
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Chronic superphysiologic AMH promotes premature luteinization of antral follicles in human ovarian xenografts..
8.
2022
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Specific mesoderm subset derived from human pluripotent stem cells ameliorates microvascular pathology in type 2 diabetic mice..
8.
2022
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Therapeutic antibody activation of the glucocorticoid-induced TNF receptor by a clustering mechanism..
8.
2022
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Mutant glucocerebrosidase impairs α-synuclein degradation by blockade of chaperone-mediated autophagy..
8.
2022
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Chemically induced protein cage assembly with programmable opening and cargo release..
8.
2022
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Synaptic vesicle pools are a major hidden resting metabolic burden of nerve terminals..
7.
2021
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The metabolic adaptation evoked by arginine enhances the effect of radiation in brain metastases..
7.
2021
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Emerging SARS-CoV-2 variants of concern evade humoral immune responses from infection and vaccination..
7.
2021
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Multiform antimicrobial resistance from a metabolic mutation..
7.
2021
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Nanodissected elastically loaded clathrin lattices relax to increased curvature..
7.
2021
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Isoflavone diet ameliorates experimental autoimmune encephalomyelitis through modulation of gut bacteria depleted in patients with multiple sclerosis..
7.
2021
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Quantitative description of a contractile macromolecular machine..
7.
2021
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Cortical response to naturalistic stimuli is largely predictable with deep neural networks..
7.
2021
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Longitudinal antibody repertoire in "mild" versus "severe" COVID-19 patients reveals immune markers associated with disease severity and resolution..
7.
2021
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Cryo-EM structures of excitatory amino acid transporter 3 visualize coupled substrate, sodium, and proton binding and transport..
7.
2021
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Kinetics of osmotic stress regulate a cell fate switch of cell survival..
7.
2021
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Targeting oncoproteins with a positive selection assay for protein degraders..
7.
2021
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A diagnostic host response biosignature for COVID-19 from RNA profiling of nasal swabs and blood..
7.
2021
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Multilayer fabrication of durable catheter-deployable soft robotic sensor arrays for efficient left atrial mapping..
6.
2020
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Histone demethylase LSD1 is critical for endochondral ossification during bone fracture healing..
6.
2020
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Liver-expressed Cd302 and Cr1l limit hepatitis C virus cross-species transmission to mice..
6.
2020
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A 3D atlas of the dynamic and regional variation of pancreatic innervation in diabetes..
6.
2020
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IL-10-producing Tfh cells accumulate with age and link inflammation with age-related immune suppression..
6.
2020
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PET, image-guided HDAC inhibition of pediatric diffuse midline glioma improves survival in murine models..
6.
2020
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Sequential deconstruction of composite drug transport in metastatic breast cancer..
6.
2020
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TET2 deficiency reprograms the germinal center B cell epigenome and silences genes linked to lymphomagenesis..
6.
2020
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Single-molecule transport kinetics of a glutamate transporter homolog shows static disorder..
6.
2020
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Mathematical prediction of clinical outcomes in advanced cancer patients treated with checkpoint inhibitor immunotherapy..
6.
2020
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The surface stress of biomedical silicones is a stimulant of cellular response..
6.
2020
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PHOTACs enable optical control of protein degradation..
6.
2020
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Endocannabinoid genetic variation enhances vulnerability to THC reward in adolescent female mice..
6.
2020
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Structure and mechanism of bactericidal mammalian perforin-2, an ancient agent of innate immunity..
6.
2020
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Molecular phenotyping and image-guided surgical treatment of melanoma using spectrally distinct ultrasmall core-shell silica nanoparticles..
5.
2019
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Reprogramming of DNA methylation at NEUROD2-bound sequences during cortical neuron differentiation..
5.
2019
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A deep learning virtual instrument for monitoring extreme UV solar spectral irradiance..
5.
2019
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3D-printed automation for optimized PET radiochemistry..
5.
2019
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The regulatory B cell-mediated peripheral tolerance maintained by mast cell IL-5 suppresses oxazolone-induced contact hypersensitivity..
5.
2019
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Targeting thrombogenicity and inflammation in chronic HIV infection..
5.
2019
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Strictures of a microchannel impose fierce competition to select for highly motile sperm..
5.
2019
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Human consciousness is supported by dynamic complex patterns of brain signal coordination..
5.
2019
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MRGPR-mediated activation of local mast cells clears cutaneous bacterial infection and protects against reinfection..
5.
2019
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Multiple modes of PRC2 inhibition elicit global chromatin alterations in H3K27M pediatric glioma..
4.
2018
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The CCT chaperonin is a novel regulator of Ca2+ signaling through modulation of Orai1 trafficking..
4.
2018
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Cross-species systems analysis identifies gene networks differentially altered by sleep loss and depression..
4.
2018
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Substrate-modulated unwinding of transmembrane helices in the NSS transporter LeuT..
4.
2018
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Variant ribosomal RNA alleles are conserved and exhibit tissue-specific expression..
4.
2018
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Impaired cohesion and homologous recombination during replicative aging in budding yeast..
4.
2018
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Real-time quantitative analysis of metabolic flux in live cells using a hyperpolarized micromagnetic resonance spectrometer..
3.
2017
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TIE2-mediated tyrosine phosphorylation of H4 regulates DNA damage response by recruiting ABL1..
2.
2016
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The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment..
1.
2015
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Cancer did not stay home for COVID-19..
6.
2020
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Epigenetics and aging.
2016
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Alpha-synuclein seed amplification assays: Data sharing, standardization needed for clinical use.
2025
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Social media: Why sharing interferes with telling true from false.
2023
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The doors of precision: Reenergizing psychiatric drug development with psychedelics and open access computational tools.
2022
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Immunogenicity of clinically relevant SARS-CoV-2 vaccines in nonhuman primates and humans.
2021
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Current status of opioid addiction treatment and related preclinical research.
2019
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How do lncRNAs regulate transcription?
2017
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