Aging and Lung Disease. Review uri icon



  • People worldwide are living longer, and it is estimated that by 2050, the proportion of the world's population over 60 years of age will nearly double. Natural lung aging is associated with molecular and physiological changes that cause alterations in lung function, diminished pulmonary remodeling and regenerative capacity, and increased susceptibility to acute and chronic lung diseases. As the aging population rapidly grows, it is essential to examine how alterations in cellular function and cell-to-cell interactions of pulmonary resident cells and systemic immune cells contribute to a higher risk of increased susceptibility to infection and development of chronic diseases, such as chronic obstructive pulmonary disease and interstitial pulmonary fibrosis. This review provides an overview of physiological, structural, and cellular changes in the aging lung and immune system that facilitate the development and progression of disease.

publication date

  • November 15, 2019



  • Aging
  • Lung Diseases


Scopus Document Identifier

  • 85079252050

Digital Object Identifier (DOI)

  • 10.1146/annurev-physiol-021119-034610

PubMed ID

  • 31730381

Additional Document Info


  • 82