Heather Winona Stout-Delgado Associate Professor of Immunology in Medicine

Associate Professor of Immunology in Medicine, Medicine , Weill Cornell Medical College 2021 -
Assistant Professor of Immunology in Medicine, Medicine , Weill Cornell Medical College 2014 - 2021

Publications

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selected publications

Heightened cholesterol 25-hydroxylase expression in aged lung during Streptococcus pneumoniae. Frontiers in aging. 2024 Academic Article GET IT
Leptin signaling maintains autonomic stability during severe influenza infection in mice. The Journal of clinical investigation. 2024 Academic Article GET IT
Role of Mitofusin 1 in mediating reactive oxygen species in alveolar macrophages during Streptococcuspneumoniae. Redox biology. 2024 Academic Article GET IT
Retraction Note: NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages. Nature medicine. 2023 Article GET IT
Times cited: 1
Impact of Senolytic Treatment on Gene Expression in Aged Lung. International journal of molecular sciences. 2023 Academic Article GET IT
Times cited: 3
Role of Cholesterol 25-Hydroxylase (Ch25h) in Mediating Innate Immune Responses to Streptococcus pneumoniae Infection. Cells. 2023 Academic Article GET IT
The Role of Glutathione Reductase in Influenza Infection. American journal of respiratory cell and molecular biology. 2022 Academic Article GET IT
Antiviral Gene Expression in Young and Aged Murine Lung during H1N1 and H3N2. International journal of molecular sciences. 2021 Academic Article GET IT
Association of circulating cell-free double-stranded DNA and metabolic derangements in idiopathic pulmonary fibrosis. Thorax. 2021 Academic Article GET IT
Times cited: 9
Cytokine signatures of end organ injury in COVID-19. Scientific reports. 2021 Academic Article GET IT
Times cited: 33
Decreased IDO1-dependent tryptophan metabolism in aged lung during influenza. The European respiratory journal. 2021 Academic Article GET IT
Times cited: 9
RIPK3 Activates MLKL-mediated Necroptosis and Inflammasome Signaling during Streptococcus Infection. American journal of respiratory cell and molecular biology. 2021 Academic Article GET IT
Times cited: 31
Hepcidin Is Essential for Alveolar Macrophage Function and Is Disrupted by Smoke in a Murine Chronic Obstructive Pulmonary Disease Model. Journal of immunology (Baltimore, Md. : 1950). 2020 Academic Article GET IT
Times cited: 16
Impact of Influenza on Pneumococcal Vaccine Effectiveness during Streptococcus pneumoniae Infection in Aged Murine Lung. Vaccines. 2020 Academic Article GET IT
Targeted antioxidants as therapeutics for treatment of pneumonia in the elderly. Translational research : the journal of laboratory and clinical medicine. 2020 Review GET IT
Times cited: 6
DROSHA-Dependent miRNA and AIM2 Inflammasome Activation in Idiopathic Pulmonary Fibrosis. International journal of molecular sciences. 2020 Information Resource GET IT
Times cited: 17
GLUT1-dependent glycolysis regulates exacerbation of fibrosis via AIM2 inflammasome activation. Thorax. 2019 Academic Article GET IT
Times cited: 54
Aging and Lung Disease. Annual review of physiology. 2019 Information Resource GET IT
Times cited: 275
DROSHA-Dependent AIM2 Inflammasome Activation Contributes to Lung Inflammation during Idiopathic Pulmonary Fibrosis. Cells. 2019 Academic Article GET IT
Importance of Mcl-1 for Alveolar Macrophage Apoptosis-associated Bacterial Killing. American journal of respiratory and critical care medicine. 2019 Comment GET IT
Times cited: 1
Mitochondrial Dysfunction in Aged Macrophages and Lung during Primary Streptococcus pneumoniae Infection is Improved with Pirfenidone. Scientific reports. 2019 Academic Article GET IT
Times cited: 35
Decreased NLRP3 inflammasome expression in aged lung may contribute to increased susceptibility to secondary Streptococcus pneumoniae infection. Experimental gerontology. 2017 Academic Article GET IT
Times cited: 13
NLRP3 inflammasome activation in aged macrophages is diminished during Streptococcus pneumoniae infection. American journal of physiology. Lung cellular and molecular physiology. 2017 Academic Article GET IT
Times cited: 31
Glucose Transporter 1-Dependent Glycolysis Is Increased during Aging-Related Lung Fibrosis, and Phloretin Inhibits Lung Fibrosis. American journal of respiratory cell and molecular biology. 2017 Academic Article GET IT
Times cited: 100
Age-Dependent Susceptibility to Pulmonary Fibrosis Is Associated with NLRP3 Inflammasome Activation. American journal of respiratory cell and molecular biology. 2016 Academic Article GET IT
Times cited: 111
NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages. Nature medicine. 2016 Academic Article GET IT
Age-enhanced endoplasmic reticulum stress contributes to increased Atg9A inhibition of STING-mediated IFN-β production during Streptococcus pneumoniae infection. Journal of immunology (Baltimore, Md. : 1950). 2014 Academic Article GET IT
Times cited: 37
Human metapneumovirus inhibits the IL-6-induced JAK/STAT3 signalling cascade in airway epithelium. The Journal of general virology. 2013 Academic Article GET IT
Times cited: 18
Impaired NLRP3 inflammasome function in elderly mice during influenza infection is rescued by treatment with nigericin. Journal of immunology (Baltimore, Md. : 1950). 2012 Academic Article GET IT
Times cited: 85
Nanoparticle delivery of mycophenolic acid upregulates PD-L1 on dendritic cells to prolong murine allograft survival. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2011 Academic Article GET IT
Times cited: 61
Efficacy of a vaccine that links viral epitopes to flagellin in protecting aged mice from influenza viral infection. Vaccine. 2011 Academic Article GET IT
Times cited: 22
Aging promotes neutrophil-induced mortality by augmenting IL-17 production during viral infection. Cell host & microbe. 2009 Academic Article GET IT
Times cited: 108
Granzyme C supports efficient CTL-mediated killing late in primary alloimmune responses. Journal of immunology (Baltimore, Md. : 1950). 2008 Academic Article GET IT
Times cited: 24
Aging impairs IFN regulatory factor 7 up-regulation in plasmacytoid dendritic cells during TLR9 activation. Journal of immunology (Baltimore, Md. : 1950). 2008 Academic Article GET IT
Times cited: 131
Intrahepatic lymphocyte expression of dipeptidyl peptidase I-processed granzyme B and perforin induces hepatocyte expression of serine proteinase inhibitor 6 (Serpinb9/SPI-6). Journal of immunology (Baltimore, Md. : 1950). 2007 Academic Article GET IT
Times cited: 16
The role of serpinb9/serine protease inhibitor 6 in preventing granzyme B-dependent hepatotoxicity. Hepatology (Baltimore, Md.). 2007 Academic Article GET IT
Times cited: 21

Research

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Co-investigator Network

Funding awarded

Multidisciplinary Approach Training in Respiratory Research awarded by National Heart, Lung, & Blood Institute Principal Investigator 2023 - 2028
Impact of Aging on Oxysterol Regulation of Alveolar Macrophage Function during S. pneumoniae awarded by National Institute on Aging Principal Investigator 2023 - 2028

Alveolar Macrophage Iron-induced Dysfunction in COPD Pathogenesis awarded by Parker B. Francis Foundation Key Personnel 2022 - 2025

Background

education and training

Ph.D., University of Texas Southwestern Medical School 2007
B.S., University of Texas at Dallas 2002

Contact

full name

Heather Winona Stout-Delgado

primary email

hes2019@med.cornell.edu