Microglial microRNAs mediate sex-specific responses to tau pathology. Academic Article uri icon

Overview

abstract

  • Sex is a key modifier of neurological disease outcomes. Microglia are implicated in neurological diseases and modulated by microRNAs, but it is unknown whether microglial microRNAs have sex-specific influences on disease. We show in mice that microglial microRNA expression differs in males and females and that loss of microRNAs leads to sex-specific changes in the microglial transcriptome and tau pathology. These findings suggest that microglial microRNAs influence tau pathogenesis in a sex-specific manner.

publication date

  • December 23, 2019

Research

keywords

  • Brain
  • MicroRNAs
  • Microglia
  • Sex Characteristics
  • Tauopathies

Identity

PubMed Central ID

  • PMC7394069

Scopus Document Identifier

  • 85077155433

Digital Object Identifier (DOI)

  • 10.1038/s41593-019-0560-7

PubMed ID

  • 31873194

Additional Document Info

volume

  • 23

issue

  • 2