selected publications
- Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model. Neuron. 2024 Academic Article GET IT
- iPSC-induced neurons with the V337M MAPT mutation are selectively vulnerable to caspase-mediated cleavage of tau and apoptotic cell death. Molecular and cellular neurosciences. 2024 Academic Article GET IT
- Cellular and pathological functions of tau. Nature reviews. Molecular cell biology. 2024 Review GET IT
- Anti-acetylated-tau immunotherapy is neuroprotective in tauopathy and brain injury. Molecular neurodegeneration. 2024 Academic Article GET IT
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Neuroinflammation generated by HIV-infected microglia promotes dysfunction and death of neurons in human brain organoids.
PNAS nexus.
2024
Academic Article
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Times cited: 3 - APOE3 - R136S mutation confers resilience against tau pathology via cGAS-STING-IFN inhibition. 2024 GET IT
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Human iPSC 4R tauopathy model uncovers modifiers of tau propagation.
Cell.
2024
Academic Article
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Times cited: 3 - ScISOr-ATAC reveals convergent and divergent splicing and chromatin specificities between matched cell types across cortical regions, evolution, and in Alzheimer's Disease. 2024 GET IT
- Artificial intelligence and open science in discovery of disease-modifying medicines for Alzheimer's disease. Cell reports. Medicine. 2024 Review GET IT
- Mechanisms of sex differences in Alzheimer's disease. Neuron. 2024 Review GET IT
- KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss. The Journal of clinical investigation. 2024 Academic Article GET IT
- Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model. 2024 GET IT
- Novel avenues of tau research. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024 Review GET IT
- Cultivation, Differentiation, and Lentiviral Transduction of Human-Induced Pluripotent Stem Cell (hiPSC)-Derived Glutamatergic Neurons for Studying Human Tau. Methods in molecular biology (Clifton, N.J.). 2024 Academic Article GET IT
- A global view of aging and Alzheimer's pathogenesis-associated cell population dynamics and molecular signatures in human and mouse brains. Nature genetics. 2023 Academic Article GET IT
- Mechanism and therapeutic potential of targeting cGAS-STING signaling in neurological disorders. Molecular neurodegeneration. 2023 Review GET IT
- DAP12 deficiency alters microglia-oligodendrocyte communication and enhances resilience against tau toxicity. 2023 GET IT
- DAP12 deficiency alters microglia-oligodendrocyte communication and enhances resilience against tau toxicity. 2023 GET IT
- Functional characterization of Alzheimer's disease genetic variants in microglia. Nature genetics. 2023 Academic Article GET IT
- Sex Chromosomes and Gonads Shape the Sex-Biased Transcriptomic Landscape in Tlr7-Mediated Demyelination During Aging. 2023 GET IT
- Alzheimer risk-increasing TREM2 variant causes aberrant cortical synapse density and promotes network hyperexcitability in mouse models. Neurobiology of disease. 2023 Academic Article GET IT
- Human iPSC 4R tauopathy model uncovers modifiers of tau propagation. 2023 GET IT
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Autophagy prevents microglial senescence.
Nature cell biology.
2023
Academic Article
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Times cited: 8 -
Tau activation of microglial cGAS-IFN reduces MEF2C-mediated cognitive resilience.
Nature neuroscience.
2023
Academic Article
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Times cited: 32 - Transposable elements and Alzheimer's disease pathogenesis. Trends in neurosciences. 2022 Academic Article GET IT
- Friend turned foe: TREM2 agonist in battles against tau. The Journal of experimental medicine. 2022 Editorial Article GET IT
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X-linked ubiquitin-specific peptidase 11 increases tauopathy vulnerability in women.
Cell.
2022
Academic Article
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Times cited: 57 -
A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states.
Nature neuroscience.
2022
Academic Article
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Times cited: 85 - The Application of Artificial Neural Network Combined with Virtual Reality Technology in Environment Art Design. Computational intelligence and neuroscience. 2022 Academic Article GET IT
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Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy.
Nature communications.
2022
Academic Article
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Times cited: 123 -
Familial natural short sleep mutations reduce Alzheimer pathology in mice.
iScience.
2022
Academic Article
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Times cited: 8 -
Single-nuclei isoform RNA sequencing unlocks barcoded exon connectivity in frozen brain tissue.
Nature biotechnology.
2022
Academic Article
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Times cited: 50 -
Mutant glucocerebrosidase impairs α-synuclein degradation by blockade of chaperone-mediated autophagy.
Science advances.
2022
Academic Article
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Times cited: 16 -
Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration.
Cell.
2022
Academic Article
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Times cited: 124 -
AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation.
Science translational medicine.
2021
Academic Article
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Times cited: 58 -
New insights and therapeutic opportunities for progranulin-deficient frontotemporal dementia.
Current opinion in neurobiology.
2021
Review
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Times cited: 1 -
Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice.
Nature communications.
2021
Academic Article
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Times cited: 114 -
Reducing acetylated tau is neuroprotective in brain injury.
Cell.
2021
Academic Article
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Times cited: 110 -
Sex Differences in Neurodegeneration: The Role of the Immune System in Humans.
Biological psychiatry.
2021
Review
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Times cited: 30 -
A MAC2-positive progenitor-like microglial population is resistant to CSF1R inhibition in adult mouse brain.
eLife.
2020
Academic Article
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Times cited: 49 -
Discovery of small molecules that normalize the transcriptome and enhance cysteine cathepsin activity in progranulin-deficient microglia.
Scientific reports.
2020
Academic Article
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Times cited: 15 -
Nanoscopic Visualization of Restricted Nonvolume Cholinergic and Monoaminergic Transmission with Genetically Encoded Sensors.
Nano letters.
2020
Academic Article
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Times cited: 15 -
Astrocyte senescence promotes glutamate toxicity in cortical neurons.
PloS one.
2020
Academic Article
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Times cited: 121 -
Promoting tau secretion and propagation by hyperactive p300/CBP via autophagy-lysosomal pathway in tauopathy.
Molecular neurodegeneration.
2020
Academic Article
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Times cited: 73 -
Microglial microRNAs mediate sex-specific responses to tau pathology.
Nature neuroscience.
2019
Academic Article
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Times cited: 75 -
Preferential tau aggregation in von Economo neurons and fork cells in frontotemporal lobar degeneration with specific MAPT variants.
Acta neuropathologica communications.
2019
Academic Article
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Times cited: 32 -
A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies.
Stem cell reports.
2019
Academic Article
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Times cited: 52 -
Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis.
Neuron.
2019
Academic Article
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Times cited: 85 -
Mapping cis-regulatory chromatin contacts in neural cells links neuropsychiatric disorder risk variants to target genes.
Nature genetics.
2019
Academic Article
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Times cited: 110 -
Do Microglial Sex Differences Contribute to Sex Differences in Neurodegenerative Diseases?.
Trends in molecular medicine.
2019
Review
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Times cited: 75 -
Proximal recolonization by self-renewing microglia re-establishes microglial homeostasis in the adult mouse brain.
PLoS biology.
2019
Academic Article
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Times cited: 105 -
Regulation of Tau Homeostasis and Toxicity by Acetylation.
2019
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Times cited: 4 -
Military-related risk factors for dementia.
Alzheimer's & dementia : the journal of the Alzheimer's Association.
2018
Review
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Times cited: 19 -
Converging pathways in neurodegeneration, from genetics to mechanisms.
Nature neuroscience.
2018
Review
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Times cited: 320 -
Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy.
Proceedings of the National Academy of Sciences of the United States of America.
2018
Academic Article
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Times cited: 105 -
The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders.
Cell.
2018
Review
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Times cited: 84 -
Transcription Factor-Mediated Differentiation of Human iPSCs into Neurons.
Current protocols in cell biology.
2018
Academic Article
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Times cited: 192 -
Tau-mediated synaptic and neuronal dysfunction in neurodegenerative disease.
Current opinion in neurobiology.
2018
Review
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Times cited: 85 -
Nav1.1-Overexpressing Interneuron Transplants Restore Brain Rhythms and Cognition in a Mouse Model of Alzheimer's Disease.
Neuron.
2018
Academic Article
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Times cited: 154 -
SIRT1 Deacetylates Tau and Reduces Pathogenic Tau Spread in a Mouse Model of Tauopathy.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2018
Academic Article
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Times cited: 107 -
Systematic Three-Dimensional Coculture Rapidly Recapitulates Interactions between Human Neurons and Astrocytes.
Stem cell reports.
2017
Academic Article
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Times cited: 74 -
Endo-lysosomal dysfunction: a converging mechanism in neurodegenerative diseases.
Current opinion in neurobiology.
2017
Review
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Times cited: 41 -
Scalable Production of iPSC-Derived Human Neurons to Identify Tau-Lowering Compounds by High-Content Screening.
Stem cell reports.
2017
Academic Article
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Times cited: 189 -
An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons.
The Journal of biological chemistry.
2017
Academic Article
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Times cited: 107 -
An 8-week, open-label, dose-finding study of nimodipine for the treatment of progranulin insufficiency from GRN gene mutations.
Alzheimer's & dementia (New York, N. Y.).
2017
Academic Article
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Times cited: 30 -
Microglial NFκB-TNFα hyperactivation induces obsessive-compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia.
Proceedings of the National Academy of Sciences of the United States of America.
2017
Academic Article
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Times cited: 89 -
Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis.
Science translational medicine.
2017
Academic Article
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Times cited: 137 -
Acetylated tau in Alzheimer's disease: An instigator of synaptic dysfunction underlying memory loss: Increased levels of acetylated tau blocks the postsynaptic signaling required for plasticity and promotes memory deficits associated with tauopathy.
BioEssays : news and reviews in molecular, cellular and developmental biology.
2017
Review
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Times cited: 48 -
Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment.
Molecular neurodegeneration.
2016
Academic Article
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Times cited: 107 -
Critical data-based re-evaluation of minocycline as a putative specific microglia inhibitor.
Glia.
2016
Review
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Times cited: 106 -
Targeting microglia for the treatment of Alzheimer's Disease.
Glia.
2016
Review
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Times cited: 105 -
Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss.
Neuron.
2016
Academic Article
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Times cited: 186 -
Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits.
Nature medicine.
2015
Academic Article
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Times cited: 387 -
Reducing inflammation and rescuing FTD-related behavioral deficits in progranulin-deficient mice with α7 nicotinic acetylcholine receptor agonists.
Biochemical pharmacology.
2015
Academic Article
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Times cited: 12 -
SIRT1 deficiency in microglia contributes to cognitive decline in aging and neurodegeneration via epigenetic regulation of IL-1β.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2015
Academic Article
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Times cited: 206 -
Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models.
Nature medicine.
2014
Academic Article
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Times cited: 187 -
Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD.
The Journal of experimental medicine.
2014
Academic Article
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Times cited: 78 -
Sirtuins in neurodegenerative diseases: an update on potential mechanisms.
Frontiers in aging neuroscience.
2013
Review
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Times cited: 110 -
Poly(ADP-ribose) polymerase-1-induced NAD(+) depletion promotes nuclear factor-κB transcriptional activity by preventing p65 de-acetylation.
Biochimica et biophysica acta.
2013
Academic Article
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Times cited: 50 -
Argyrophilic grain disease differs from other tauopathies by lacking tau acetylation.
Acta neuropathologica.
2013
Academic Article
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Times cited: 85 -
Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury.
The Journal of clinical investigation.
2012
Academic Article
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Times cited: 244 -
Cathepsin B degrades amyloid-β in mice expressing wild-type human amyloid precursor protein.
The Journal of biological chemistry.
2012
Academic Article
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Times cited: 87 -
Transcriptional expression patterns triggered by chemically distinct neuroprotective molecules.
Neuroscience.
2012
Academic Article
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Times cited: 5 -
Selective targeting of microglia by quantum dots.
Journal of neuroinflammation.
2012
Academic Article
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Times cited: 65 -
Poly(ADP-ribose)polymerase-1 modulates microglial responses to amyloid β.
Journal of neuroinflammation.
2011
Academic Article
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Times cited: 92 -
Protective effects and mechanisms of sirtuins in the nervous system.
Progress in neurobiology.
2011
Review
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Times cited: 182 -
CX3CR1 protein signaling modulates microglial activation and protects against plaque-independent cognitive deficits in a mouse model of Alzheimer disease.
The Journal of biological chemistry.
2011
Academic Article
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Times cited: 220 -
Manipulation of gene expression in the central nervous system with lentiviral vectors.
Methods in molecular biology (Clifton, N.J.).
2011
Academic Article
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Times cited: 7 -
Acetylation of tau inhibits its degradation and contributes to tauopathy.
Neuron.
2010
Academic Article
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Times cited: 783 -
Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer's Disease.
Cell stem cell.
2009
Academic Article
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Times cited: 181 -
Cystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimer's disease.
Neuron.
2008
Academic Article
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Times cited: 188 -
Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease.
Nature neuroscience.
2008
Academic Article
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Times cited: 315 -
Therapeutic potential of sirtuin-activating compounds in Alzheimer's disease.
Drug news & perspectives.
2007
Review
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Times cited: 25 -
Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease.
Neuron.
2006
Academic Article
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Times cited: 297 -
SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling.
The Journal of biological chemistry.
2005
Academic Article
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Times cited: 606 -
Intracellularly generated amyloid-beta peptide counteracts the antiapoptotic function of its precursor protein and primes proapoptotic pathways for activation by other insults in neuroblastoma cells.
Journal of neurochemistry.
2004
Academic Article
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Times cited: 35 -
New non-viral method for gene transfer into primary cells.
Methods (San Diego, Calif.).
2004
Academic Article
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Times cited: 195 -
Identification of cathepsin B as a mediator of neuronal death induced by Abeta-activated microglial cells using a functional genomics approach.
The Journal of biological chemistry.
2003
Academic Article
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Times cited: 111 -
Localization of the Slack potassium channel in the rat central nervous system.
The Journal of comparative neurology.
2002
Academic Article
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Times cited: 120 -
Specific interference with gene expression and gene function mediated by long dsRNA in neural cells.
Journal of neuroscience methods.
2002
Academic Article
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Times cited: 56 -
Cell type-specific expression of the Kv3.1 gene is mediated by a negative element in the 5' untranslated region of the Kv3.1 promoter.
Journal of neurochemistry.
1999
Academic Article
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Times cited: 15 -
Wild-type but not Alzheimer-mutant amyloid precursor protein confers resistance against p53-mediated apoptosis.
Proceedings of the National Academy of Sciences of the United States of America.
1999
Academic Article
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Times cited: 79 -
Formation of intermediate-conductance calcium-activated potassium channels by interaction of Slack and Slo subunits.
Nature neuroscience.
1998
Academic Article
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Times cited: 129 -
When, where, and how much? Expression of the Kv3.1 potassium channel in high-frequency firing neurons.
Journal of neurobiology.
1998
Review
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Times cited: 85 -
Contribution of the Kv3.1 potassium channel to high-frequency firing in mouse auditory neurones.
The Journal of physiology.
1998
Academic Article
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Times cited: 296 -
Cloning and characterization of the promoter for a potassium channel expressed in high frequency firing neurons.
The Journal of biological chemistry.
1996
Academic Article
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Times cited: 43 -
Electrophysiological and pharmacological characterization of a mammalian Shaw channel expressed in NIH 3T3 fibroblasts.
Journal of neurophysiology.
1995
Academic Article
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Times cited: 100