Transposable elements and Alzheimer's disease pathogenesis. Academic Article uri icon

Overview

abstract

  • Alzheimer's disease (AD) is characterized by the pathological accumulation of amyloid β (Aβ) plaques and neurofibrillary tangles composed of hyperphosphorylated tau. Microglia and astrocytes respond to the abnormal presence of tau protein with induced transposable element (TE) transcription. In this Forum, we discuss new data that link dysregulated TE expression to AD pathogenesis.

publication date

  • December 30, 2022

Research

keywords

  • Alzheimer Disease

Identity

Digital Object Identifier (DOI)

  • 10.1016/j.tins.2022.12.003

PubMed ID

  • 36588011