A one-pot radiosynthesis of [18 F]PARPi. Academic Article uri icon

Overview

abstract

  • In this paper, we disclose a new strategy for the radiosynthesis of [18 F]PARPi from the corresponding, boc-protected, nitro-precursor. Using a two-step procedure, [18 F]PARPi could be isolated in radiochemical yields up to 9.6%. The reaction proceeds via an efficient one-pot, two-step process, allowing for simplification over previous methods that require complex multi-step, multi-pot strategies to be implemented.

publication date

  • June 16, 2020

Research

keywords

  • Fluorine Radioisotopes
  • Poly(ADP-ribose) Polymerase Inhibitors
  • Poly(ADP-ribose) Polymerases
  • Radiochemistry
  • Radiopharmaceuticals

Identity

PubMed Central ID

  • PMC7551923

Scopus Document Identifier

  • 85086445491

Digital Object Identifier (DOI)

  • 10.1002/jlcr.3847

PubMed ID

  • 32391930

Additional Document Info

volume

  • 63

issue

  • 9