Molecular Competition in G1 Controls When Cells Simultaneously Commit to Terminally Differentiate and Exit the Cell Cycle. Academic Article uri icon

Overview

abstract

  • Terminal differentiation is essential for the development and maintenance of tissues in all multi-cellular organisms and is associated with permanent exit from the cell cycle. Failure to permanently exit the cell cycle can result in cancer and disease. However, the molecular mechanisms and timing that coordinate differentiation commitment and cell cycle exit are not yet understood. Using live, single-cell imaging of cell cycle progression and differentiation commitment during adipogenesis, we show that a rapid switch mechanism engages exclusively in G1 to trigger differentiation commitment simultaneously with permanent exit from the cell cycle. We identify a molecular competition in G1 between when the differentiation switch is triggered and when the proliferative window closes that allows mitogen and differentiation stimuli to control the balance between terminally differentiating cells produced and progenitor cells kept in reserve, a parameter of critical importance for enabling proper development of tissue domains and organs.

publication date

  • June 16, 2020

Research

keywords

  • Cell Cycle
  • Cell Differentiation
  • Cell Division
  • Stem Cells

Identity

PubMed Central ID

  • PMC8198760

Scopus Document Identifier

  • 85086365704

Digital Object Identifier (DOI)

  • 10.1016/j.celrep.2020.107769

PubMed ID

  • 32553172

Additional Document Info

volume

  • 31

issue

  • 11