Dynamic 3D Chromatin Reorganization during Establishment and Maintenance of Pluripotency. Review uri icon

Overview

abstract

  • Higher-order chromatin structure is tightly linked to gene expression and therefore cell identity. In recent years, the chromatin landscape of pluripotent stem cells has become better characterized, and unique features at various architectural levels have been revealed. However, the mechanisms that govern establishment and maintenance of these topological characteristics and the temporal and functional relationships with transcriptional or epigenetic features are still areas of intense study. Here, we will discuss progress and limitations of our current understanding regarding how the 3D chromatin topology of pluripotent stem cells is established during somatic cell reprogramming and maintained during cell division. We will also discuss evidence and theories about the driving forces of topological reorganization and the functional links with key features and properties of pluripotent stem cell identity.

publication date

  • November 25, 2020

Research

keywords

  • Cell Division
  • Cellular Reprogramming
  • Chromatin
  • Chromatin Assembly and Disassembly
  • Pluripotent Stem Cells

Identity

PubMed Central ID

  • PMC7724465

Scopus Document Identifier

  • 85096975425

Digital Object Identifier (DOI)

  • 10.1016/j.stemcr.2020.10.012

PubMed ID

  • 33242398

Additional Document Info

volume

  • 15

issue

  • 6