Apostolou, Eftychia

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CRISPR screening uncovers a long-range enhancer for ONECUT1 in pancreatic differentiation and links a diabetes risk variant. Cell reports. 2024 Academic Article GET IT
Genetic variation modulates susceptibility to aberrant DNA hypomethylation and imprint deregulation in naïve pluripotent stem cells. 2024 GET IT
TAD hierarchy restricts poised LTR activation and loss of TAD hierarchy promotes LTR co-option in cancer. 2024 GET IT
Transcriptional remodeling by OTX2 directs specification and patterning of mammalian definitive endoderm. 2024 GET IT
CRISPR Screening Uncovers a Long-Range Enhancer for ONECUT1 in Pancreatic Differentiation and Links a Diabetes Risk Variant. 2024 GET IT
3D Enhancer-promoter networks provide predictive features for gene expression and coregulation in early embryonic lineages. Nature structural & molecular biology. 2023 Academic Article GET IT
Dynamic network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer gene regulatory activity during cell state transitions. Nature genetics. 2023 Academic Article GET IT
Times cited: 215
3D enhancer-promoter interactions and multi-connected hubs: Organizational principles and functional roles. Cell reports. 2023 Review GET IT
Progress and challenges in stem cell biology. Nature cell biology. 2023 Academic Article GET IT
A Knock-in Mouse Model of Thymoma with the GTF2I L424H Mutation. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2022 Academic Article GET IT
A bipartite element with allele-specific functions safeguards DNA methylation imprints at the Dlk1-Dio3 locus. Developmental cell. 2021 Academic Article GET IT
Times cited: 19
OCT2 pre-positioning facilitates cell fate transition and chromatin architecture changes in humoral immunity. Nature immunology. 2021 Academic Article GET IT
Deciphering the Complexity of 3D Chromatin Organization Driving Lymphopoiesis and Lymphoid Malignancies. Frontiers in immunology. 2021 Information Resource GET IT
Times cited: 10
H3K27ac bookmarking promotes rapid post-mitotic activation of the pluripotent stem cell program without impacting 3D chromatin reorganization. Molecular cell. 2021 Academic Article GET IT
Times cited: 48
Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture. Nature. 2020 Academic Article GET IT
Times cited: 150
Dynamic 3D Chromatin Reorganization during Establishment and Maintenance of Pluripotency. Stem cell reports. 2020 Information Resource GET IT
Times cited: 19
Context-Dependent Requirement of Euchromatic Histone Methyltransferase Activity during Reprogramming to Pluripotency. Stem cell reports. 2020 Academic Article GET IT
Times cited: 8
Transcription factors: building hubs in the 3D space. Cell cycle (Georgetown, Tex.). 2020 Information Resource GET IT
Times cited: 39
A Susceptibility Locus on Chromosome 13 Profoundly Impacts the Stability of Genomic Imprinting in Mouse Pluripotent Stem Cells. Cell reports. 2020 Academic Article GET IT
Times cited: 4
EpiMethylTag: simultaneous detection of ATAC-seq or ChIP-seq signals with DNA methylation. Genome biology. 2019 Academic Article GET IT
Times cited: 26
KLF4 is involved in the organization and regulation of pluripotency-associated three-dimensional enhancer networks. Nature cell biology. 2019 Academic Article GET IT
Times cited: 114
Identification of Cancer Drivers at CTCF Insulators in 1,962 Whole Genomes. Cell systems. 2019 Academic Article GET IT
Times cited: 50
TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC Regulatory Network. Molecular cell. 2019 Academic Article GET IT
Times cited: 30
A hPSC-based platform to discover gene-environment interactions that impact human β-cell and dopamine neuron survival. Nature communications. 2018 Academic Article GET IT
Times cited: 27
Cellular trajectories and molecular mechanisms of iPSC reprogramming. Current opinion in genetics & development. 2018 Review GET IT
Times cited: 44
Shaping the Pluripotent Genome: Switches, Borders, and Loops. Cell stem cell. 2018 Article GET IT
Nascent Induced Pluripotent Stem Cells Efficiently Generate Entirely iPSC-Derived Mice while Expressing Differentiation-Associated Genes. Cell reports. 2018 Academic Article GET IT
Times cited: 9
Widespread Mitotic Bookmarking by Histone Marks and Transcription Factors in Pluripotent Stem Cells. Cell reports. 2017 Academic Article GET IT
Times cited: 92
Expression of type III interferons (IFNλs) and their receptor in Sjögren's syndrome. Clinical and experimental immunology. 2016 Academic Article GET IT
Times cited: 33
The Chromatin Signature of Pluripotency: Establishment and Maintenance. Current stem cell reports. 2016 Information Resource GET IT
Local Genome Topology Can Exhibit an Incompletely Rewired 3D-Folding State during Somatic Cell Reprogramming. Cell stem cell. 2016 Academic Article GET IT
Times cited: 98
A Serial shRNA Screen for Roadblocks to Reprogramming Identifies the Protein Modifier SUMO2. Stem cell reports. 2016 Academic Article GET IT
Times cited: 44
PRC2 Is Required to Maintain Expression of the Maternal Gtl2-Rian-Mirg Locus by Preventing De Novo DNA Methylation in Mouse Embryonic Stem Cells. Cell reports. 2015 Academic Article GET IT
Times cited: 55
F-class cells: new routes and destinations for induced pluripotency. Cell stem cell. 2015 Academic Article GET IT
Times cited: 4
Small molecules facilitate rapid and synchronous iPSC generation. Nature methods. 2014 Academic Article GET IT
Times cited: 82
Distinct and combinatorial functions of Jmjd2b/Kdm4b and Jmjd2c/Kdm4c in mouse embryonic stem cell identity. Molecular cell. 2013 Academic Article GET IT
Times cited: 100
Rearranging the chromatin for pluripotency. Cell cycle (Georgetown, Tex.). 2013 Editorial Article GET IT
Times cited: 7
Chromatin dynamics during cellular reprogramming. Nature. 2013 Information Resource GET IT
Times cited: 313
Genome-wide chromatin interactions of the Nanog locus in pluripotency, differentiation, and reprogramming. Cell stem cell. 2013 Academic Article GET IT
Times cited: 169
A molecular roadmap of reprogramming somatic cells into iPS cells. Cell. 2012 Academic Article GET IT
Times cited: 693
Regulation of pluripotency and cellular reprogramming by the ubiquitin-proteasome system. Cell stem cell. 2012 Academic Article GET IT
Times cited: 228
Ascorbic acid prevents loss of Dlk1-Dio3 imprinting and facilitates generation of all-iPS cell mice from terminally differentiated B cells. Nature genetics. 2012 Academic Article GET IT
Times cited: 246
Genomic analysis reveals a novel nuclear factor-κB (NF-κB)-binding site in Alu-repetitive elements. The Journal of biological chemistry. 2011 Academic Article GET IT
Times cited: 48
Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells. Nature biotechnology. 2010 Academic Article GET IT
Times cited: 997
Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells. Nature. 2010 Academic Article GET IT
Times cited: 672
Pericentromeric instability and spontaneous emergence of human neoacrocentric and minute chromosomes in the alternative pathway of telomere lengthening. Cancer research. 2008 Academic Article GET IT
Times cited: 19
Virus Infection Induces NF-kappaB-dependent interchromosomal associations mediating monoallelic IFN-beta gene expression. Cell. 2008 Academic Article GET IT
Times cited: 179

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Research

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Funding awarded

Identifying and targeting 3D regulatory nodes that maintain glioblastoma programs. awarded by National Institute of Neurological Disorders & Stroke Principal Investigator 2024 - 2029
Characterizing stem cell-like B cell subpopulations and dissecting their role in tumorigenesis awarded by National Cancer Institute Principal Investigator 2023 - 2028
Interrogation of chromatin dynamics of pancreas cancer cell state transitions in 4D awarded by Starr Cancer Consortium Principal Investigator 2024 - 2026
Combing omics and imaging approaches to dissect critical regulatory proteins and enhancer hierarchies during pluripotent state transitions awarded by Tri-Institutional Stem Cell Initiative (Weill Cornell) Principal Investigator 2023 - 2025
Interrogation of the chromatin landscape to drive maturation of hPSC-derived skeletal muscle. awarded by Tri-Institutional Stem Cell Initiative (Weill Cornell) Principal Investigator 2023 - 2025
Organizational principles and functional role of 3D enhancer hubs in cell fate decisions awarded by National Institute of General Medical Sciences Principal Investigator 2020 - 2025
missing activity Principal Investigator 2021 - 2024

Dissecting genetic determinants of epigenetic instability in pluripotent stem cells awarded by National Institute of General Medical Sciences Co-Investigator 2022 - 2026
A human embryonic stem cell-based platform to understand the association between neuronal maturation and neurodevelopmental disease awarded by Tri-Institutional Stem Cell Initiative (Weill Cornell) Co-Investigator 2023 - 2024
Novel approaches to explore principles of epigenetic gene regulation during neurogenesis awarded by Tri-Institutional Stem Cell Initiative (Weill Cornell) Co-Investigator 2020 - 2022

A transgenic toolbox to dissect molecular pathologies caused by OTX2 deficiency during ex vivo human ectoderm development awarded by National Institute of Neurological Disorders & Stroke Key Personnel 2023 - 2024

Gene regulatory networks in early lung epithelial cell fate decisions awarded by National Heart, Lung, & Blood Institute Principal Investigator Subaward 2023 - 2027
Structure, Function, and Dynamics of Macro-molecular Complexes that Execute and Regulate Genome Function awarded by National Institute on Minority Health & Health Disparities Principal Investigator Subaward 2021 - 2026
Discovery of diabetes-relevant β cell enhancers through 4D enhancer mapping, integrative analysis, and large-scale CRISPRi perturbation screens awarded by Stand Up To Cancer Principal Investigator Subaward 2020 - 2025
missing activity Principal Investigator Subaward 2018 - 2024

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Background

education and training

Ph.D., University of Athens, Faculty of Medicine (Greece) 2009
B.Sc., Aristotle University of Thessaloniki (Greece) 2003

Contact

full name

Eftychia Apostolou

primary email

efa2001@med.cornell.edu

VIVO Weill Cornell Medical College

Eftychia Apostolou Associate Professor of Molecular Biology in Medicine

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email