Transient concordant distributions of nicotinic receptors and acetylcholinesterase activity in infant rat visual cortex.

Overview

For a short period during the second week after birth, layer IV of rat visual cortex displays intense acetylcholinesterase (AChE) activity which demarcates area 17. We now report that this transient AChE pattern is paralleled by a marked increase in [3H]nicotine binding sites in layer IV of area 17. Muscarinic receptors show a different pattern. Neonatal bilateral enucleation results in a reduction of AChE reaction product and [3H]nicotine labelling in area 17, while leaving the pattern of muscarinic labelling virtually unaffected. The close association of [3H]nicotine labelling and AChE activity suggests that presynaptic nicotinic cholinergic receptors may modulate transmitter release while functional geniculocortical synapses are being formed.