Cooperative action of gut-microbiota-accessible carbohydrates improves host metabolic function. Academic Article uri icon

Overview

abstract

  • Microbiota-accessible carbohydrates (MACs) exert health-promoting effects, but how each MAC impacts gut microbiota and regulates host physiology remains unclear. Here, we show that l-arabinose and sucrose cooperatively act on gut microbiota and exert anti-obesogenic effects. Specifically, l-arabinose, a monosaccharide that is poorly absorbed in the gut and inhibits intestinal sucrase, suppresses diet-induced obesity in mice in the presence of sucrose. Additionally, the suppressive effect of l-arabinose on adiposity is abrogated in mice lacking the short-chain fatty acid (SCFA) receptors GPR43 and GPR41. Mechanistically, l-arabinose increases the relative abundance of acetate and propionate producers (e.g., Bacteroides), while sucrose enhances SCFA production. Furthermore, l-arabinose and sucrose activate the glycolytic and pentose phosphate pathways of Bacteroides, respectively, indicating that they synergistically promote acetate production through distinct pathways. These findings suggest that each MAC has a unique property and thus may serve as a precision gut-microbiota modulator to promote host homeostasis.

publication date

  • July 19, 2022

Research

keywords

  • Gastrointestinal Microbiome
  • Microbiota

Identity

Scopus Document Identifier

  • 85134777535

Digital Object Identifier (DOI)

  • 10.1016/j.celrep.2022.111087

PubMed ID

  • 35858544

Additional Document Info

volume

  • 40

issue

  • 3