New readers and writers of RNA modifications unique to leukemia stem cells. uri icon

Overview

abstract

  • Chemical modifications of RNA are regulated by a series of readers, writers, and erasers that dictate gene expression. Two new studies in Cell Stem Cell1,2identify roles for the N6-methyladenosine (m6A) methyltransferase METTL16 and the m6A reader IGF2BP2 in leukemia-initiating cells, illuminating exciting new therapeutic targets for leukemia.

publication date

  • January 5, 2023

Research

keywords

  • Leukemia
  • RNA

Identity

Scopus Document Identifier

  • 85145182534

Digital Object Identifier (DOI)

  • 10.1016/j.stem.2022.12.011

PubMed ID

  • 36608677

Additional Document Info

volume

  • 30

issue

  • 1