Balancing lysosome abundance in health and disease. Review uri icon

Overview

abstract

  • Lysosomes are catabolic organelles that govern numerous cellular processes, including macromolecule degradation, nutrient signalling and ion homeostasis. Aberrant changes in lysosome abundance are implicated in human diseases. Here we outline the mechanisms of lysosome biogenesis and turnover, and discuss how changes in the lysosome pool impact physiological and pathophysiological processes.

publication date

  • August 14, 2023

Research

keywords

  • Lysosomes
  • Organelles

Identity

Digital Object Identifier (DOI)

  • 10.1038/s41556-023-01197-7

PubMed ID

  • 37580388