selected publications
- Genome-wide CRISPR screens in spheroid culture reveal that the tumor suppressor LKB1 inhibits growth via the PIKFYVE lipid kinase. Proceedings of the National Academy of Sciences of the United States of America. 2024 Academic Article GET IT
- Nutrient signaling: Starvation flips a phosphoinositide switch on lysosomal catabolism. Current biology : CB. 2023 Academic Article GET IT
- LKB1 suppresses growth and promotes the internalization of EGFR through the PIKFYVE lipid kinase. 2023 GET IT
- Balancing lysosome abundance in health and disease. Nature cell biology. 2023 Review GET IT
- Altered propionate metabolism contributes to tumour progression and aggressiveness. Nature metabolism. 2022 Academic Article GET IT
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Rap1-GTPases control mTORC1 activity by coordinating lysosome organization with amino acid availability.
Nature communications.
2020
Academic Article
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Times cited: 56 -
Dynamic Incorporation of Histone H3 Variants into Chromatin Is Essential for Acquisition of Aggressive Traits and Metastatic Colonization.
Cancer cell.
2019
Academic Article
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Times cited: 67 -
Regulation of GSK3 cellular location by FRAT modulates mTORC1-dependent cell growth and sensitivity to rapamycin.
Proceedings of the National Academy of Sciences of the United States of America.
2019
Academic Article
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Times cited: 19 -
ERK2 regulates epithelial-to-mesenchymal plasticity through DOCK10-dependent Rac1/FoxO1 activation.
Proceedings of the National Academy of Sciences of the United States of America.
2019
Academic Article
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Times cited: 64 -
mTORC1 Promotes Metabolic Reprogramming by the Suppression of GSK3-Dependent Foxk1 Phosphorylation.
Molecular cell.
2018
Academic Article
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Times cited: 106 -
Signal inhibition by a dynamically regulated pool of monophosphorylated MAPK.
Molecular biology of the cell.
2015
Academic Article
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Times cited: 18 -
Quantitative phosphoproteomic analysis reveals system-wide signaling pathways downstream of SDF-1/CXCR4 in breast cancer stem cells.
Proceedings of the National Academy of Sciences of the United States of America.
2014
Academic Article
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Times cited: 104 -
Proper protein glycosylation promotes mitogen-activated protein kinase signal fidelity.
Biochemistry.
2012
Academic Article
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Times cited: 8 -
Combined computational and experimental analysis reveals mitogen-activated protein kinase-mediated feedback phosphorylation as a mechanism for signaling specificity.
Molecular biology of the cell.
2012
Academic Article
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Times cited: 16 -
Positive roles for negative regulators in the mating response of yeast.
Molecular systems biology.
2012
Academic Article
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Times cited: 13 -
Checkpoints in a yeast differentiation pathway coordinate signaling during hyperosmotic stress.
PLoS genetics.
2012
Academic Article
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Times cited: 38 -
Regulation of cell signaling dynamics by the protein kinase-scaffold Ste5.
Molecular cell.
2008
Academic Article
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Times cited: 101 -
Analysis of the aerobactin and ferric hydroxamate uptake systems of Yersinia pestis.
Microbiology (Reading, England).
2007
Academic Article
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Times cited: 20 -
Emergence of a bacterial clone with enhanced virulence by acquisition of a phage encoding a secreted phospholipase A2.
Proceedings of the National Academy of Sciences of the United States of America.
2006
Academic Article
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Times cited: 74 -
Molecular genetic anatomy of inter- and intraserotype variation in the human bacterial pathogen group A Streptococcus.
Proceedings of the National Academy of Sciences of the United States of America.
2006
Academic Article
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Times cited: 160 -
Crystal structure of group A streptococcus Mac-1: insight into dimer-mediated specificity for recognition of human IgG.
Structure (London, England : 1993).
2006
Academic Article
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Times cited: 24 -
Genome sequence of a serotype M28 strain of group a streptococcus: potential new insights into puerperal sepsis and bacterial disease specificity.
The Journal of infectious diseases.
2005
Academic Article
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Times cited: 195 -
Analysis of a novel prophage-encoded group A Streptococcus extracellular phospholipase A(2).
The Journal of biological chemistry.
2004
Academic Article
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Times cited: 33