Direct sensing of dietary ω-6 linoleic acid through FABP5-mTORC1 signaling. Academic Article uri icon

Overview

abstract

  • Diet influences macronutrient availability to cells, and although mechanisms of sensing dietary glucose and amino acids are well characterized, less is known about sensing lipids. We defined a nutrient signaling mechanism involving fatty acid-binding protein 5 (FABP5) and mechanistic target of rapamycin complex 1 (mTORC1) that is activated by the essential polyunsaturated fatty acid (PUFA) ω-6 linoleic acid (LA). FABP5 directly bound to the regulatory-associated protein of mTOR (Raptor) to enhance formation of functional mTORC1 and substrate binding, ultimately converging on increased mTOR signaling and proliferation. The amounts of FABP5 protein were increased in tumors and serum from triple-negative compared with those from receptor-positive breast cancer patients, which highlights its potential role as a biomarker that mediates cellular responses to ω-6 LA intake in this disease subtype.

publication date

  • March 14, 2025

Research

keywords

  • Fatty Acid-Binding Proteins
  • Linoleic Acid
  • Mechanistic Target of Rapamycin Complex 1
  • Signal Transduction
  • TOR Serine-Threonine Kinases

Identity

Digital Object Identifier (DOI)

  • 10.1126/science.adm9805

PubMed ID

  • 40080571

Additional Document Info

volume

  • 387

issue

  • 6739