Epithelial responses to fungal pathogens. Review uri icon

Overview

abstract

  • Epithelial cells orchestrate immune responses against fungal pathogens. This review highlights advances in integrating epithelial cells in immune responses against inhaled molds and dimorphic fungi, and against Candida species that colonize mucosal surfaces. In the lung, epithelial cells respond to interleukin-1 (IL-1) and interferon signaling to regulate effector cell influx and fungal killing. In the alimentary and vulvovaginal tracts, epithelial cells modulate fungal commensalism, invasive growth, and local immune tone, in part by responding to damage caused by candidalysin, a C. albicans peptide toxin, and through IL-17-dependent release of antimicrobial peptides that contribute to Candida colonization resistance. Understanding fungal-epithelial interactions in mammalian models of disease is critical to predict vulnerabilities and to identify opportunities for immune-based strategies to treat fungal infections.

publication date

  • July 10, 2024

Research

keywords

  • Epithelial Cells

Identity

PubMed Central ID

  • PMC11331878

Scopus Document Identifier

  • 85197755180

Digital Object Identifier (DOI)

  • 10.1016/j.mib.2024.102508

PubMed ID

  • 38986398

Additional Document Info

volume

  • 80