Hohl, Tobias M.

Publications

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selected publications

Evaluating the clinical utility of Aspergillus, Mucorales, and Nocardia bronchoalveolar PCRs for the diagnosis of invasive pulmonary infections in patients with hematological malignancies. Journal of clinical microbiology. 2025 Academic Article GET IT
Perforin-2 is dispensable for host defense against Aspergillus fumigatus and Candida albicans. mSphere. 2024 Academic Article GET IT
An IFN-STAT1-CYBB Axis Defines Protective Plasmacytoid DC to Neutrophil Crosstalk During Aspergillus fumigatus Infection. 2024 GET IT
Perforin-2 is dispensable for host defense against Aspergillus fumigatus and Candida albicans. 2024 GET IT
Antifungal heteroresistance causes prophylaxis failure and facilitates breakthrough Candida parapsilosis infections. Nature medicine. 2024 Academic Article GET IT
Epithelial responses to fungal pathogens. Current opinion in microbiology. 2024 Review GET IT
Plasma membrane abundance dictates phagocytic capacity and functional cross-talk in myeloid cells. Science immunology. 2024 Academic Article GET IT
BTK drives neutrophil activation for sterilizing antifungal immunity. The Journal of clinical investigation. 2024 Academic Article GET IT
Oral bacteria relative abundance in faeces increases due to gut microbiota depletion and is linked with patient outcomes. Nature microbiology. 2024 Academic Article GET IT
GM-CSF-mediated epithelial-immune cell crosstalk orchestrates pulmonary immunity to Aspergillus fumigatus. 2024 GET IT
Dectin-1/CARD9 induction of the TFEB and TFE3 gene network is dispensable for phagocyte anti-Aspergillus activity in the lung. Infection and immunity. 2023 Academic Article GET IT
Aspergillus fumigatus cytochrome c impacts conidial survival during sterilizing immunity. mSphere. 2023 Academic Article GET IT
Plasma membrane abundance dictates phagocytic capacity and functional crosstalk in myeloid cells. 2023 GET IT
Inflammatory ER stress responses dictate the immunopathogenic progression of systemic candidiasis. The Journal of clinical investigation. 2023 Academic Article GET IT
Times cited: 6
Dectin-1/CARD9-induction of the TFEB and TFE3 gene network is dispensable for phagocyte anti- Aspergillus activity in the lung. 2023 GET IT
Aspergillus fumigatus cytochrome c impacts conidial survival during sterilizing immunity. 2023 GET IT
Worldwide emergence of fluconazole-resistant Candida parapsilosis: current framework and future research roadmap. The Lancet. Microbe. 2023 Review GET IT
Times cited: 2
Immunocompromised Host Pneumonia: Definitions and Diagnostic Criteria: An Official American Thoracic Society Workshop Report. Annals of the American Thoracic Society. 2023 Academic Article GET IT
Immunity to fungi in the lung. Seminars in immunology. 2023 Review GET IT
Times cited: 27
Conditioning Regimens are Associated with Distinct Patterns of Microbiota Injury in Allogeneic Hematopoietic Cell Transplantation. Clinical cancer research : an official journal of the American Association for Cancer Research. 2023 Academic Article GET IT
Times cited: 25
Immune responses to human fungal pathogens and therapeutic prospects. Nature reviews. Immunology. 2023 Review GET IT
Times cited: 119
Profiling the Fungal Microbiome after Fecal Microbiota Transplantation for Graft-versus-Host Disease: Insights from a Phase 1 Interventional Study. Transplantation and cellular therapy. 2022 Academic Article GET IT
Cutting Edge: Neutrophils License the Maturation of Monocytes into Effective Antifungal Effectors. Journal of immunology (Baltimore, Md. : 1950). 2022 Academic Article GET IT
Times cited: 11
Systematic Analysis of Copy Number Variations in the Pathogenic Yeast Candida parapsilosis Identifies a Gene Amplification in RTA3 That is Associated with Drug Resistance. mBio. 2022 Academic Article GET IT
Times cited: 17
The Effect of Neutropenia and Filgrastim (G-CSF) on Cancer Patients With Coronavirus Disease 2019 (COVID-19) Infection. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2022 Academic Article GET IT
Times cited: 24
Customization of a DADA2-based pipeline for fungal internal transcribed spacer 1 (ITS1) amplicon data sets. JCI insight. 2022 Academic Article GET IT
Times cited: 18
Identification of a novel Candida metapsilosis isolate reveals multiple hybridization events. G3 (Bethesda, Md.). 2022 Academic Article GET IT
Times cited: 10
Haematopoietic cell transplantation outcomes are linked to intestinal mycobiota dynamics and an expansion of Candida parapsilosis complex species. Nature microbiology. 2021 Academic Article GET IT
Times cited: 39
Candida albicans Isolates 529L and CHN1 Exhibit Stable Colonization of the Murine Gastrointestinal Tract. mBio. 2021 Academic Article GET IT
Times cited: 36
Clinical and Genomic Characterization of SARS CoV-2 infections in mRNA Vaccinated Health Care Personnel in New York City. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2021 Academic Article GET IT
Global guideline for the diagnosis and management of the endemic mycoses: an initiative of the European Confederation of Medical Mycology in cooperation with the International Society for Human and Animal Mycology. The Lancet. Infectious diseases. 2021 Review GET IT
Times cited: 14
Mitochondrial Reactive Oxygen Species Enhance Alveolar Macrophage Activity against Aspergillus fumigatus but Are Dispensable for Host Protection. mSphere. 2021 Academic Article GET IT
Times cited: 10
Aspergillus fumigatus Strain-Specific Conidia Lung Persistence Causes an Allergic Broncho-Pulmonary Aspergillosis-Like Disease Phenotype. mSphere. 2021 Academic Article GET IT
Times cited: 10
Rapid transcriptional and metabolic adaptation of intestinal microbes to host immune activation. Cell host & microbe. 2021 Academic Article GET IT
Times cited: 60
Fungal Bioreporters to Monitor Outcomes of Aspergillus: Host-Cell Interactions. 2021 GET IT
Fungal Bioreporters to Monitor Outcomes of Blastomyces: Host-Cell Interactions. 2021 GET IT
Favorable outcomes of COVID-19 in recipients of hematopoietic cell transplantation. The Journal of clinical investigation. 2020 Academic Article GET IT
Times cited: 103
Shedding of Viable SARS-CoV-2 after Immunosuppressive Therapy for Cancer. The New England journal of medicine. 2020 Letter GET IT
Times cited: 339
The gut microbiota is associated with immune cell dynamics in humans. Nature. 2020 Academic Article GET IT
Times cited: 337
Enhancing mucosal immunity by transient microbiota depletion. Nature communications. 2020 Academic Article GET IT
Times cited: 12
Bacterial immunotherapy for cancer induces CD4-dependent tumor-specific immunity through tumor-intrinsic interferon-γ signaling. Proceedings of the National Academy of Sciences of the United States of America. 2020 Academic Article GET IT
Times cited: 73
Minority report: the intestinal mycobiota in systemic infections. Current opinion in microbiology. 2020 Review GET IT
Times cited: 23
Determinants of COVID-19 disease severity in patients with cancer. Nature medicine. 2020 Academic Article GET IT
Times cited: 475
During Aspergillus Infection, Monocyte-Derived DCs, Neutrophils, and Plasmacytoid DCs Enhance Innate Immune Defense through CXCR3-Dependent Crosstalk. Cell host & microbe. 2020 Academic Article GET IT
Times cited: 58
Platelets are critical for survival and tissue integrity during murine pulmonary Aspergillus fumigatus infection. PLoS pathogens. 2020 Academic Article GET IT
Times cited: 18
Antibiotic Degradation by Commensal Microbes Shields Pathogens. Infection and immunity. 2020 Academic Article GET IT
Times cited: 20
CARD9⁺ microglia promote antifungal immunity via IL-1β- and CXCL1-mediated neutrophil recruitment. Nature immunology. 2019 Academic Article GET IT
Times cited: 172
Menacing Mold: Recent Advances in Aspergillus Pathogenesis and Host Defense. Journal of molecular biology. 2019 Review GET IT
Times cited: 41
Inflammatory monocytes are detrimental to the host immune response during acute infection with Cryptococcus neoformans. PLoS pathogens. 2019 Academic Article GET IT
Times cited: 45
Serious Infections in Patients Receiving Ibrutinib for Treatment of Lymphoid Cancer. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2018 Academic Article GET IT
Times cited: 219
Cytokine Release Syndrome Grade as a Predictive Marker for Infections in Patients With Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia Treated With Chimeric Antigen Receptor T Cells. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2018 Academic Article GET IT
Times cited: 212
Interleukin 1α Is Critical for Resistance against Highly Virulent Aspergillus fumigatus Isolates. Infection and immunity. 2017 Academic Article GET IT
Times cited: 52
Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death. Science (New York, N.Y.). 2017 Academic Article GET IT
Times cited: 79
A CCR2+ myeloid cell niche required for pancreatic β cell growth. JCI insight. 2017 Academic Article GET IT
Times cited: 17
Immune responses to invasive aspergillosis: new understanding and therapeutic opportunities. Current opinion in infectious diseases. 2017 Review GET IT
Times cited: 25
Immunity against fungi. JCI insight. 2017 Information Resource GET IT
Times cited: 107
Live Imaging of Antifungal Activity by Human Primary Neutrophils and Monocytes in Response to A. fumigatus. Journal of visualized experiments : JoVE. 2017 Academic Article GET IT
Times cited: 8
Validation of single nucleotide polymorphisms in invasive aspergillosis following hematopoietic cell transplantation. Blood. 2017 Academic Article GET IT
Times cited: 78
BCAP inhibits proliferation and differentiation of myeloid progenitors in the steady state and during demand situations. Blood. 2017 Academic Article GET IT
Times cited: 7
Flow Cytometry of Lung and Bronchoalveolar Lavage Fluid Cells from Mice Challenged with Fluorescent Aspergillus Reporter (FLARE) Conidia. Bio-protocol. 2016 Academic Article GET IT
Heterogeneity among Isolates Reveals that Fitness in Low Oxygen Correlates with Aspergillus fumigatus Virulence. mBio. 2016 Academic Article GET IT
Times cited: 93
New advances in invasive aspergillosis immunobiology leading the way towards personalized therapeutic approaches. Cytokine. 2016 Information Resource GET IT
Times cited: 11
DAP12 Inhibits Pulmonary Immune Responses to Cryptococcus neoformans. Infection and immunity. 2016 Academic Article GET IT
Times cited: 10
Monocyte-mediated defense against bacteria, fungi, and parasites. Seminars in immunology. 2016 Information Resource GET IT
Times cited: 58
Role of Granulocyte-Macrophage Colony-Stimulating Factor Signaling in Regulating Neutrophil Antifungal Activity and the Oxidative Burst During Respiratory Fungal Challenge. The Journal of infectious diseases. 2016 Academic Article GET IT
Times cited: 53
CARD9-Dependent Neutrophil Recruitment Protects against Fungal Invasion of the Central Nervous System. PLoS pathogens. 2015 Academic Article GET IT
Times cited: 172
Zinc and Manganese Chelation by Neutrophil S100A8/A9 (Calprotectin) Limits Extracellular Aspergillus fumigatus Hyphal Growth and Corneal Infection. Journal of immunology (Baltimore, Md. : 1950). 2015 Academic Article GET IT
Times cited: 124
Intestinal Monocyte-Derived Macrophages Control Commensal-Specific Th17 Responses. Cell reports. 2015 Academic Article GET IT
Times cited: 111
Compartment-specific and sequential role of MyD88 and CARD9 in chemokine induction and innate defense during respiratory fungal infection. PLoS pathogens. 2015 Academic Article GET IT
Times cited: 94
Myeloid derived hypoxia inducible factor 1-alpha is required for protection against pulmonary Aspergillus fumigatus infection. PLoS pathogens. 2014 Academic Article GET IT
Times cited: 72
Nitric oxide regulates BAFF expression and T cell-independent antibody responses. Journal of immunology (Baltimore, Md. : 1950). 2014 Academic Article GET IT
Times cited: 20
Independent contribution of bronchoalveolar lavage and serum galactomannan in the diagnosis of invasive pulmonary aspergillosis. Transplant infectious disease : an official journal of the Transplantation Society. 2014 Academic Article GET IT
Times cited: 15
Overview of vertebrate animal models of fungal infection. Journal of immunological methods. 2014 Information Resource GET IT
Times cited: 58
Inflammatory monocytes orchestrate innate antifungal immunity in the lung. PLoS pathogens. 2014 Academic Article GET IT
Times cited: 145
Reply to King and Stover. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2013 Article GET IT
Reply to Mikulska et al. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2013 Article GET IT
Resident renal mononuclear phagocytes comprise five discrete populations with distinct phenotypes and functions. Journal of immunology (Baltimore, Md. : 1950). 2013 Academic Article GET IT
Times cited: 112
Inflammatory monocytes mediate early and organ-specific innate defense during systemic candidiasis. The Journal of infectious diseases. 2013 Academic Article GET IT
Times cited: 112
The serum galactomannan index predicts mortality in hematopoietic stem cell transplant recipients with invasive aspergillosis. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2013 Academic Article GET IT
Times cited: 56
Monocyte- and macrophage-targeted NADPH oxidase mediates antifungal host defense and regulation of acute inflammation in mice. Journal of immunology (Baltimore, Md. : 1950). 2013 Academic Article GET IT
Times cited: 67
Genetic and pharmacological targeting of CSF-1/CSF-1R inhibits tumor-associated macrophages and impairs BRAF-induced thyroid cancer progression. PloS one. 2013 Academic Article GET IT
Times cited: 121
Hypoxia enhances innate immune activation to Aspergillus fumigatus through cell wall modulation. Microbes and infection. 2012 Academic Article GET IT
Times cited: 64
Tracing conidial fate and measuring host cell antifungal activity using a reporter of microbial viability in the lung. Cell reports. 2012 Academic Article GET IT
Times cited: 95
Immunity to fungi. Current opinion in immunology. 2012 Information Resource GET IT
Times cited: 88
Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense. Immunity. 2012 Academic Article GET IT
Times cited: 406
Monocytic CCR2(+) myeloid-derived suppressor cells promote immune escape by limiting activated CD8 T-cell infiltration into the tumor microenvironment. Cancer research. 2011 Academic Article GET IT
Times cited: 308
Ly6G+ neutrophils are dispensable for defense against systemic Listeria monocytogenes infection. Journal of immunology (Baltimore, Md. : 1950). 2011 Academic Article GET IT
Times cited: 110
In vivo hypoxia and a fungal alcohol dehydrogenase influence the pathogenesis of invasive pulmonary aspergillosis. PLoS pathogens. 2011 Academic Article GET IT
Times cited: 190
Bone marrow mesenchymal stem and progenitor cells induce monocyte emigration in response to circulating toll-like receptor ligands. Immunity. 2011 Academic Article GET IT
Times cited: 409
Dectin-1 diversifies Aspergillus fumigatus-specific T cell responses by inhibiting T helper type 1 CD4 T cell differentiation. The Journal of experimental medicine. 2011 Academic Article GET IT
Times cited: 140
Monocyte trafficking to hepatic sites of bacterial infection is chemokine independent and directed by focal intercellular adhesion molecule-1 expression. Journal of immunology (Baltimore, Md. : 1950). 2010 Academic Article GET IT
Times cited: 85
In vivo bioluminescence imaging and histopathopathologic analysis reveal distinct roles for resident and recruited immune effector cells in defense against invasive aspergillosis. BMC microbiology. 2010 Academic Article GET IT
Times cited: 70
Inflammatory monocytes facilitate adaptive CD4 T cell responses during respiratory fungal infection. Cell host & microbe. 2009 Academic Article GET IT
Times cited: 292
Essential role for neutrophils but not alveolar macrophages at early time points following Aspergillus fumigatus infection. The Journal of infectious diseases. 2009 Academic Article GET IT
Times cited: 188
Selective expansion of the monocytic lineage directed by bacterial infection. Journal of immunology (Baltimore, Md. : 1950). 2009 Academic Article GET IT
Times cited: 101
Caspofungin modulates inflammatory responses to Aspergillus fumigatus through stage-specific effects on fungal beta-glucan exposure. The Journal of infectious diseases. 2008 Academic Article GET IT
Times cited: 101
Monocyte-mediated defense against microbial pathogens. Annual review of immunology. 2008 Information Resource GET IT
Times cited: 905
Cracking the fungal armor. Nature medicine. 2006 Article GET IT
Times cited: 6
Immunity to fungi. Current opinion in immunology. 2006 Information Resource GET IT
Times cited: 74
Aspergillus fumigatus triggers inflammatory responses by stage-specific beta-glucan display. PLoS pathogens. 2005 Academic Article GET IT
Times cited: 379
Distinct CD4+-T-cell responses to live and heat-inactivated Aspergillus fumigatus conidia. Infection and immunity. 2005 Academic Article GET IT
Times cited: 79
Video-rate nonlinear microscopy of neuronal membrane dynamics with genetically encoded probes. Journal of neurophysiology. 2004 Academic Article GET IT
Times cited: 60
Molecular mass, stoichiometry, and assembly of 20 S particles. The Journal of biological chemistry. 2001 Academic Article GET IT
Times cited: 35
Arrangement of subunits in 20 S particles consisting of NSF, SNAPs, and SNARE complexes. Molecular cell. 1998 Academic Article GET IT
Times cited: 109
A revised model for the oligomeric state of the N-ethylmaleimide-sensitive fusion protein, NSF. The Journal of biological chemistry. 1998 Academic Article GET IT
Times cited: 77

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Background

education and training

M.D., Weill Cornell Medical College, Cornell University 2001
Ph.D., Cornell University Graduate School of Medical Sciences 2000
B.S., Duke University 1993

Contact

full name

Tobias M. Hohl

primary email

hohlt@mskcc.org

VIVO Weill Cornell Medical College

Tobias M. Hohl Professor of Medicine

Publications

selected publications

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Background

education and training

Contact

full name

primary email