A Siah3 of relief: A role for mitophagy as a fail-safe during developmental axon pruning. Academic Article uri icon

Overview

abstract

  • Developmental axon pruning is controlled by a careful balance of pro- and anti-apoptotic signals, which are activated in response to external cues to sculpt mature neuronal circuitry. In this issue of Science Signaling, Abraham et al. define a safeguard against apoptotic axon pruning and illustrate that Siah3 represses Parkin-mediated mitophagy to control the availability of axonal mitochondria that activate the pruning process.

publication date

  • October 8, 2024

Research

keywords

  • Axons
  • Mitochondria
  • Mitophagy
  • Ubiquitin-Protein Ligases

Identity

Scopus Document Identifier

  • 85205822978

Digital Object Identifier (DOI)

  • 10.1126/scisignal.ads1228

PubMed ID

  • 39378287

Additional Document Info

volume

  • 17

issue

  • 857