Complexity of insulin resistance in early-onset colorectal cancer. Review uri icon

Overview

abstract

  • Early-life exposure to lifestyle-associated metabolic alterations could be a key contributor to early-onset colorectal cancer (EOCRC). Notably, insulin resistance (InsR)-linked hyperinsulinemia, elevated levels of insulin-like growth factors, and chronic inflammation could trigger EOCRC by modulating gene expression/pathways that support carcinogenesis/anti-apoptosis. Here, we discuss how InsR could be the trigger that offsets metabolic homeostasis in young individuals, leading to EOCRC. Furthermore, we emphasize the need for lifestyle interventions, early detection, and targeted therapeutic interventions to mitigate this growing health concern.

publication date

  • April 17, 2025

Research

keywords

  • Colorectal Neoplasms
  • Insulin Resistance

Identity

Scopus Document Identifier

  • 105003255492

Digital Object Identifier (DOI)

  • 10.1016/j.ccell.2025.03.033

PubMed ID

  • 40250447

Additional Document Info

volume

  • 43

issue

  • 5