Seeing More, Treating Smarter: Role of Long-axial Field-of-view PET/Computed Tomography in the Evolution of Theranostics.

Overview

Long-axial field-of-view (LAFOV) PET/computed tomography has the potential to redefine the role of molecular imaging in theranostics by making multiparametric whole-body imaging and predictive dosimetry more clinically feasible. Compared to conventional PET systems, LAFOV scanners provide dramatic gains in sensitivity and coverage, allowing dynamic acquisitions, delayed imaging, and dual-tracer protocols within clinically feasible workflows. These advances supply the quantitative data required for physiologically based pharmacokinetic modeling and the creation of theranostic digital twins, supporting true personalization of radiopharmaceutical therapy.