Harnessing Frémy's salt for tyrosine-directed bioconjugations. Academic Article uri icon

Overview

abstract

  • The current bioconjugation toolbox overwhelmingly comprises strategies that modify lysine and cysteine residues within proteins and peptides. Herein, we have leveraged Frémy's salt (potassium nitrosodisulfonate) to create an approach to bioconjugation predicated on the oxidation of tyrosine residues and the subsequent strain-promoted oxidation-controlled quinone ligation between the resultant 1,2-quinones and trans-cyclooctene-bearing cargoes.

publication date

  • January 20, 2026

Identity

PubMed Central ID

  • PMC12818945

Digital Object Identifier (DOI)

  • 10.1039/d5ra06489a

PubMed ID

  • 41568207

Additional Document Info

volume

  • 16

issue

  • 5