Zeglis, Brian

selected publications

Evaluating Radiotheranostic Targets for Endometrial Cancer. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2025 Academic Article GET IT
Harnessing Fc-Directed Bioconjugation for the Synthesis of Site-Specifically Modified Radioimmunoconjugates. Bioconjugate chemistry. 2025 Academic Article GET IT
Detection of HER2-Low Lesions Using HER2-Targeted PET Imaging in Patients with Metastatic Breast Cancer: A Paired HER2 PET and Tumor Biopsy Analysis. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2025 Academic Article GET IT
Comparative analysis of auger electron emission libraries and Monte Carlo track structure codes for DNA-targeted auger electron therapy. Medical physics. 2025 Academic Article GET IT
Exploring the Interplay Between Radioimmunoconjugates and Fcγ Receptors in Genetically Engineered Mouse Models of Cancer. ACS pharmacology & translational science. 2024 Academic Article GET IT
Site-specific bioconjugation and nuclear imaging. Current opinion in chemical biology. 2024 Review GET IT
Times cited: 5
Recent advances and impending challenges for the radiopharmaceutical sciences in oncology. The Lancet. Oncology. 2024 Review GET IT
Trends in nuclear medicine and the radiopharmaceutical sciences in oncology: workforce challenges and training in the age of theranostics. The Lancet. Oncology. 2024 Review GET IT
Cadherin-17 as a target for the immunoPET of adenocarcinoma. European journal of nuclear medicine and molecular imaging. 2024 Academic Article GET IT
Times cited: 2
MIB Guides: Measuring the Immunoreactivity of Radioimmunoconjugates. Molecular imaging and biology. 2024 Academic Article GET IT
Times cited: 1
Tuning Supramolecular Chirality in Iodinated Amphiphilic Peptides Through Tripeptide Linker Editing. Biomacromolecules. 2024 Academic Article GET IT
Times cited: 4
First-in-Human Evaluation of Site-Specifically Labeled ⁸⁹Zr-Pertuzumab in Patients with HER2-Positive Breast Cancer. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2024 Academic Article GET IT
Times cited: 18
Evaluating CD133 as a Radiotheranostic Target in Small-Cell Lung Cancer. Molecular pharmaceutics. 2024 Academic Article GET IT
Times cited: 4
Click Chemistry and Radiochemistry: An Update. Bioconjugate chemistry. 2023 Review GET IT
Times cited: 42
Unraveling the in vivo fate of inhaled micro- and nanoplastics with PET imaging. The Science of the total environment. 2023 Academic Article GET IT
Times cited: 20
Molecular Imaging, Radiochemistry, and Environmental Pollutants. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2023 Review GET IT
Times cited: 2
Site-selective radiolabeling using mushroom tyrosinase and the strain-promoted oxidation-controlled 1,2-quinone cycloaddition. RSC advances. 2023 Academic Article GET IT
Times cited: 6
Visualizing Galectin-3 Binding Protein Expression with ImmunoPET. Molecular pharmaceutics. 2023 Academic Article GET IT
Times cited: 6
Click chemistry: a transformative technology in nuclear medicine. Nature protocols. 2023 Review GET IT
Site-Specific Photoaffinity Bioconjugation for the Creation of ⁸⁹Zr-Labeled Radioimmunoconjugates. Molecular imaging and biology. 2023 Academic Article GET IT
Times cited: 5
Click Here for Better Chemistry. The New England journal of medicine. 2022 Academic Article GET IT
Times cited: 9
Leveraging a Dual Variable Domain Immunoglobulin to Create a Site-Specifically Modified Radioimmunoconjugate. Molecular pharmaceutics. 2022 Academic Article GET IT
Site-Specific Radiohalogenation of a HER2-Targeted Single-Domain Antibody Fragment Using a Novel Residualizing Prosthetic Agent. Journal of medicinal chemistry. 2022 Academic Article GET IT
Times cited: 16
Evolution of the vls Antigenic Variability Locus of the Lyme Disease Pathogen and Development of Recombinant Monoclonal Antibodies Targeting Conserved VlsE Epitopes. Microbiology spectrum. 2022 Academic Article GET IT
Times cited: 3
Lysine-Directed Site-Selective Bioconjugation for the Creation of Radioimmunoconjugates. Bioconjugate chemistry. 2022 Academic Article GET IT
Times cited: 10
Antibody Engineering for Nuclear Imaging and Radioimmunotherapy. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2022 Academic Article GET IT
Times cited: 18
Pretargeted PET of Osteodestructive Lesions in Dogs. Molecular pharmaceutics. 2022 Academic Article GET IT
Times cited: 15
CD133 as a Biomarker for an Autoantibody-to-ImmunoPET Paradigm for the Early Detection of Small Cell Lung Cancer. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2022 Academic Article GET IT
Times cited: 15
ImmunoPET of Ovarian and Pancreatic Cancer with AR9.6, a Novel MUC16-Targeted Therapeutic Antibody. Clinical cancer research : an official journal of the American Association for Cancer Research. 2022 Academic Article GET IT
Times cited: 29
The Impact of Tyrosine Iodination on the Aggregation and Cleavage Kinetics of MMP-9-Responsive Peptide Sequences. ACS biomaterials science & engineering. 2022 Academic Article GET IT
Times cited: 14
Inverse electron demand Diels-Alder click chemistry for pretargeted PET imaging and radioimmunotherapy. Nature protocols. 2021 Academic Article GET IT
Times cited: 34
Harnessing PET to track micro- and nanoplastics in vivo. Scientific reports. 2021 Academic Article GET IT
Times cited: 46
Synthesis and Comparative In Vivo Evaluation of Site-Specifically Labeled Radioimmunoconjugates for DLL3-Targeted ImmunoPET. Bioconjugate chemistry. 2021 Academic Article GET IT
Times cited: 14
A Theranostic Cellulose Nanocrystal-Based Drug Delivery System with Enhanced Retention in Pulmonary Metastasis of Melanoma. Small (Weinheim an der Bergstrasse, Germany). 2021 Academic Article GET IT
Times cited: 41
Targeting Triple Negative Breast Cancer with a Nucleus-Directed p53 Tetramerization Domain Peptide. Molecular pharmaceutics. 2020 Academic Article GET IT
Times cited: 5
DiPODS: A Reagent for Site-Specific Bioconjugation via the Irreversible Rebridging of Disulfide Linkages. Bioconjugate chemistry. 2020 Academic Article GET IT
Times cited: 19
On the consensus nomenclature rules for radiopharmaceutical chemistry - Reconsideration of radiochemical conversion. Nuclear medicine and biology. 2020 Letter GET IT
Times cited: 52
Harnessing ⁶⁴Cu/⁶⁷Cu for a theranostic approach to pretargeted radioimmunotherapy. Proceedings of the National Academy of Sciences of the United States of America. 2020 Academic Article GET IT
Times cited: 87
A Molecularly Targeted Intraoperative Near-Infrared Fluorescence Imaging Agent for High-Grade Serous Ovarian Cancer. Molecular pharmaceutics. 2020 Academic Article GET IT
Times cited: 17
Identification of HER2-Positive Metastases in Patients with HER2-Negative Primary Breast Cancer by Using HER2-targeted ⁸⁹Zr-Pertuzumab PET/CT. Radiology. 2020 Academic Article GET IT
Times cited: 54
⁸⁹Zr-Labeled AR20.5: A MUC1-Targeting ImmunoPET Probe. Molecules (Basel, Switzerland). 2020 Academic Article GET IT
Times cited: 8
Removal of Fc Glycans from [⁸⁹Zr]Zr-DFO-Anti-CD8 Prevents Peripheral Depletion of CD8⁺ T Cells. Molecular pharmaceutics. 2020 Academic Article GET IT
Times cited: 5
Poly(ADP-Ribose)Polymerase (PARP) Inhibitors and Radiation Therapy. Frontiers in pharmacology. 2020 Review GET IT
Times cited: 73
Manipulating the In Vivo Behaviour of ⁶⁸Ga with Tris(Hydroxypyridinone) Chelators: Pretargeting and Blood Clearance. International journal of molecular sciences. 2020 Academic Article GET IT
Times cited: 12
Targeted Brain Tumor Radiotherapy Using an Auger Emitter. Clinical cancer research : an official journal of the American Association for Cancer Research. 2020 Academic Article GET IT
Times cited: 84
The Influence of Glycans-Specific Bioconjugation on the FcγRI Binding and In vivo Performance of ⁸⁹Zr-DFO-Pertuzumab. Theranostics. 2020 Academic Article GET IT
Times cited: 44
A brief overview of metal complexes as nuclear imaging agents. Dalton transactions (Cambridge, England : 2003). 2019 Information Resource GET IT
Times cited: 38
Pretargeted radioimmunotherapy and SPECT imaging of peritoneal carcinomatosis using bioorthogonal click chemistry: probe selection and first proof-of-concept. Theranostics. 2019 Academic Article GET IT
Times cited: 26
Dual Radionuclide Theranostic Pretargeting. Molecular pharmaceutics. 2019 Academic Article GET IT
Times cited: 33
Toward the Optimization of Click-Mediated Pretargeted Radioimmunotherapy. Molecular pharmaceutics. 2019 Academic Article GET IT
Times cited: 21
Synthesis and Bioconjugation of Thiol-Reactive Reagents for the Creation of Site-Selectively Modified Immunoconjugates. Journal of visualized experiments : JoVE. 2019 Academic Article GET IT
Times cited: 5
The Impact of FcγRI Binding on Immuno-PET. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2019 Academic Article GET IT
Times cited: 48
Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction. Journal of visualized experiments : JoVE. 2019 Academic Article GET IT
Times cited: 12
Leveraging Bioorthogonal Click Chemistry to Improve ²²⁵Ac-Radioimmunotherapy of Pancreatic Ductal Adenocarcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research. 2018 Academic Article GET IT
Dendrimer Scaffold for the Amplification of In Vivo Pretargeting Ligations. Bioconjugate chemistry. 2018 Academic Article GET IT
Times cited: 33
Understanding the in vivo fate of radioimmunoconjugates for nuclear imaging. Journal of labelled compounds & radiopharmaceuticals. 2018 Review GET IT
Times cited: 33
PARP-1-Targeted Radiotherapy in Mouse Models of Glioblastoma. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2018 Academic Article GET IT
Times cited: 60
Thiol-Reactive Bifunctional Chelators for the Creation of Site-Selectively Modified Radioimmunoconjugates with Improved Stability. Bioconjugate chemistry. 2018 Academic Article GET IT
Times cited: 36
Click-Mediated Pretargeted Radioimmunotherapy of Colorectal Carcinoma. Molecular pharmaceutics. 2018 Academic Article GET IT
Times cited: 41
The inverse electron-demand Diels-Alder reaction as a new methodology for the synthesis of ²²⁵Ac-labelled radioimmunoconjugates. Chemical communications (Cambridge, England). 2018 Academic Article GET IT
Times cited: 38
Site-Specifically Labeled Antibody-Drug Conjugate for Simultaneous Therapy and ImmunoPET. Molecular pharmaceutics. 2018 Academic Article GET IT
Times cited: 40
Fc-Mediated Anomalous Biodistribution of Therapeutic Antibodies in Immunodeficient Mouse Models. Cancer research. 2018 Academic Article GET IT
Times cited: 93
Pretargeting of internalizing trastuzumab and cetuximab with a ¹⁸F-tetrazine tracer in xenograft models. EJNMMI research. 2017 Academic Article GET IT
Times cited: 68
Exploring Structural Parameters for Pretargeting Radioligand Optimization. Journal of medicinal chemistry. 2017 Academic Article GET IT
Times cited: 54
Pretargeted Imaging and Therapy. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2017 Review GET IT
Times cited: 171
ESPMIS: Helping Young Scientists Navigate the Molecular Imaging Landscape. Molecular imaging and biology. 2017 Academic Article GET IT
Noninvasive Interrogation of DLL3 Expression in Metastatic Small Cell Lung Cancer. Cancer research. 2017 Academic Article GET IT
Times cited: 93
A Novel Technique for Generating and Observing Chemiluminescence in a Biological Setting. Journal of visualized experiments : JoVE. 2017 Academic Article GET IT
Click Chemistry and Radiochemistry: The First 10 Years. Bioconjugate chemistry. 2016 Review GET IT
Times cited: 208
Establishment of the In Vivo Efficacy of Pretargeted Radioimmunotherapy Utilizing Inverse Electron Demand Diels-Alder Click Chemistry. Molecular cancer therapeutics. 2016 Academic Article GET IT
Times cited: 89
A Bone-Seeking trans-Cyclooctene for Pretargeting and Bioorthogonal Chemistry: A Proof of Concept Study Using ^99mTc- and ¹⁷⁷Lu-Labeled Tetrazines. Journal of medicinal chemistry. 2016 Academic Article GET IT
Times cited: 46
A Pretargeted Approach for the Multimodal PET/NIRF Imaging of Colorectal Cancer. Theranostics. 2016 Academic Article GET IT
Times cited: 54
Near-Infrared Intraoperative Chemiluminescence Imaging. ChemMedChem. 2016 Academic Article GET IT
Times cited: 9
Pretargeted PET Imaging Using a Site-Specifically Labeled Immunoconjugate. Bioconjugate chemistry. 2016 Academic Article GET IT
Times cited: 64
A comparative evaluation of the chelators H4octapa and CHX-A″-DTPA with the therapeutic radiometal (90)Y. Nuclear medicine and biology. 2016 Academic Article GET IT
Times cited: 25
Molecular Imaging of Ovarian Cancer. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2016 Review GET IT
Times cited: 16
Site-Specifically Labeled Immunoconjugates for Molecular Imaging--Part 2: Peptide Tags and Unnatural Amino Acids. Molecular imaging and biology. 2016 Review GET IT
Times cited: 69
Preclinical 89Zr Immuno-PET of High-Grade Serous Ovarian Cancer and Lymph Node Metastasis. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2016 Academic Article GET IT
Times cited: 37
Site-Specifically Labeled Immunoconjugates for Molecular Imaging--Part 1: Cysteine Residues and Glycans. Molecular imaging and biology. 2016 Review GET IT
Times cited: 104
Site-specifically labeled CA19.9-targeted immunoconjugates for the PET, NIRF, and multimodal PET/NIRF imaging of pancreatic cancer. Proceedings of the National Academy of Sciences of the United States of America. 2015 Academic Article GET IT
Times cited: 86
(18)F-Based Pretargeted PET Imaging Based on Bioorthogonal Diels-Alder Click Chemistry. Bioconjugate chemistry. 2015 Academic Article GET IT
Times cited: 138

VIVO Weill Cornell Medical College

Brian Zeglis Adjunct Assistant Professor of Chemistry in Radiology

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selected publications

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