The inverse electron-demand Diels-Alder reaction as a new methodology for the synthesis of 225Ac-labelled radioimmunoconjugates. Academic Article uri icon

Overview

abstract

  • The inverse electron-demand Diels-Alder reaction between tetrazine (Tz) and trans-cyclooctene (TCO) facilitates the efficient radiosynthesis of 225Ac-labelled radioimmunoconjugates in a two-step method, outperforming conventional approaches based on isothiocyanate couplings.

publication date

  • March 8, 2018

Research

keywords

  • Actinium
  • Cycloaddition Reaction
  • Electrons
  • Immunoconjugates
  • Neoplasms, Experimental
  • Radiopharmaceuticals

Identity

PubMed Central ID

  • PMC5843558

Scopus Document Identifier

  • 85043476609

Digital Object Identifier (DOI)

  • 10.1039/c7cc09129j

PubMed ID

  • 29388990

Additional Document Info

volume

  • 54

issue

  • 21