Shifting metabolism alters rRNA expression in malaria parasites.
Academic Article
Overview
abstract
Malaria parasites display the unique property of expressing distinct ribosomal RNAs at different points in their transmission cycle. Couble et al. determined that derepression of the mosquito-specific rDNA loci is initiated by altered NAD+/nicotinamide (NAM) ratios, resulting from the metabolic shift that parasites undergo as they transition into the mosquito stages.