Deitsch, Kirk W

Publications

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selected publications

Transcriptional plasticity of virulence genes provides malaria parasites with greater adaptive capacity for avoiding host immunity. 2024 GET IT
Chromatin structure and var2csa - a tango in regulation of var gene expression in the human malaria parasite, Plasmodium falciparum ? 2024 GET IT
Prevalence of Leucocytozoon infection in domestic birds in Ghana. PloS one. 2023 Academic Article GET IT
The global transcriptome of Plasmodium falciparum mid-stage gametocytes (stages II-IV) appears largely conserved and gametocyte-specific gene expression patterns vary in clinical isolates. Microbiology spectrum. 2023 Academic Article GET IT
Identification of a long noncoding RNA required for temperature induced expression of stage-specific rRNA in malaria parasites. Gene. 2023 Academic Article GET IT
Sexual differentiation in human malaria parasites is regulated by competition between phospholipid metabolism and histone methylation. Nature microbiology. 2023 Academic Article GET IT
Times cited: 1954
The human malaria parasite Plasmodium falciparum can sense environmental changes and respond by antigenic switching. Proceedings of the National Academy of Sciences of the United States of America. 2023 Academic Article GET IT
A coordinated transcriptional switching network mediates antigenic variation of human malaria parasites. eLife. 2022 Academic Article GET IT
The mystery of persistent, asymptomatic Plasmodium falciparum infections. Current opinion in microbiology. 2022 Review GET IT
Shared Mechanisms for Mutually Exclusive Expression and Antigenic Variation by Protozoan Parasites. Frontiers in cell and developmental biology. 2022 Review GET IT
Evolution of transcriptional control of antigenic variation and virulence in human and ape malaria parasites. BMC ecology and evolution. 2021 Academic Article GET IT
The Role of the Histone Methyltransferase PfSET10 in Antigenic Variation by Malaria Parasites: a Cautionary Tale. mSphere. 2021 Academic Article GET IT
Times cited: 8
Telomere length dynamics in response to DNA damage in malaria parasites. iScience. 2021 Academic Article GET IT
A Histone Methyltransferase Inhibitor Can Reverse Epigenetically Acquired Drug Resistance in the Malaria Parasite Plasmodium falciparum. Antimicrobial agents and chemotherapy. 2020 Academic Article GET IT
Times cited: 9
Vive la Différence: Exploiting the Differences between Rodent and Human Malarias. Trends in parasitology. 2020 Information Resource GET IT
Times cited: 8
Evolution of Host Specificity by Malaria Parasites through Altered Mechanisms Controlling Genome Maintenance. mBio. 2020 Academic Article GET IT
Times cited: 11
Rapid antigen diversification through mitotic recombination in the human malaria parasite Plasmodium falciparum. PLoS biology. 2019 Academic Article GET IT
Times cited: 32
Plasmodium falciparum malaria cases detected for prompt treatment by rapid diagnostic tests in the Ho Teaching Hospital of the Volta Region of Ghana. Parasite epidemiology and control. 2018 Academic Article GET IT
Times cited: 4
Gametocyte Development and Carriage in Ghanaian Individuals with Uncomplicated Plasmodium falciparum Malaria. The American journal of tropical medicine and hygiene. 2018 Academic Article GET IT
Times cited: 7
Chromosome End Repair and Genome Stability in Plasmodium falciparum. mBio. 2017 Academic Article GET IT
Times cited: 19
Parasite pathogenesis: The dynamics of chronic malaria. Nature microbiology. 2017 Article GET IT
Times cited: 1
The Link between Plasmodium falciparum Malaria and Endemic Burkitt's Lymphoma-New Insight into a 50-Year-Old Enigma. PLoS pathogens. 2016 Information Resource GET IT
Times cited: 40
Targeting protein translation, RNA splicing, and degradation by morpholino-based conjugates in Plasmodium falciparum. Proceedings of the National Academy of Sciences of the United States of America. 2015 Academic Article GET IT
Times cited: 13
Self-targeting blocks malaria parasite invasion. The Journal of experimental medicine. 2015 Article GET IT
Times cited: 2
A Unique Virulence Gene Occupies a Principal Position in Immune Evasion by the Malaria Parasite Plasmodium falciparum. PLoS genetics. 2015 Academic Article GET IT
Times cited: 32
A multifactorial role for P. falciparum malaria in endemic Burkitt's lymphoma pathogenesis. PLoS pathogens. 2014 Academic Article GET IT
Times cited: 76
Origin of robustness in generating drug-resistant malaria parasites. Molecular biology and evolution. 2014 Academic Article GET IT
Times cited: 34
Recruitment of PfSET2 by RNA polymerase II to variant antigen encoding loci contributes to antigenic variation in P. falciparum. PLoS pathogens. 2014 Academic Article GET IT
Times cited: 62
DNA secondary structures are associated with recombination in major Plasmodium falciparum variable surface antigen gene families. Nucleic acids research. 2013 Academic Article GET IT
Times cited: 33
Malaria parasites utilize both homologous recombination and alternative end joining pathways to maintain genome integrity. Nucleic acids research. 2013 Academic Article GET IT
Times cited: 74
A molecular switch in the efficiency of translation reinitiation controls expression of var2csa, a gene implicated in pregnancy-associated malaria. Molecular microbiology. 2013 Academic Article GET IT
Times cited: 33
Direct evidence for the adaptive role of copy number variation on antifolate susceptibility in Plasmodium falciparum. Molecular microbiology. 2013 Academic Article GET IT
Times cited: 43
Horizontal gene transfer of epigenetic machinery and evolution of parasitism in the malaria parasite Plasmodium falciparum and other apicomplexans. BMC evolutionary biology. 2013 Academic Article GET IT
Times cited: 27
Characterization of Plasmodium falciparum adenylyl cyclase-β and its role in erythrocytic stage parasites. PloS one. 2012 Academic Article GET IT
Times cited: 22
Molecular basis of severe malaria. Proceedings of the National Academy of Sciences of the United States of America. 2012 Article GET IT
Times cited: 9
Antigenic variation and the generation of diversity in malaria parasites. Current opinion in microbiology. 2012 Information Resource GET IT
Times cited: 36
Plasmodium falciparum STEVOR proteins impact erythrocyte mechanical properties. Blood. 2011 Academic Article GET IT
Times cited: 53
Plasmodium falciparum Sir2A preferentially hydrolyzes medium and long chain fatty acyl lysine. ACS chemical biology. 2011 Academic Article GET IT
Times cited: 58
Plasmodium falciparum var gene silencing is determined by cis DNA elements that form stable and heritable interactions. Eukaryotic cell. 2011 Academic Article GET IT
Times cited: 22
Clonally variant gene families in Plasmodium falciparum share a common activation factor. Molecular microbiology. 2009 Academic Article GET IT
Times cited: 45
The effect of Plasmodium falciparum Sir2a histone deacetylase on clonal and longitudinal variation in expression of the var family of virulence genes. International journal for parasitology. 2009 Academic Article GET IT
Times cited: 20
Common strategies for antigenic variation by bacterial, fungal and protozoan pathogens. Nature reviews. Microbiology. 2009 Information Resource GET IT
Times cited: 248
An unusual recent expansion of the C-terminal domain of RNA polymerase II in primate malaria parasites features a motif otherwise found only in mammalian polymerases. Journal of molecular evolution. 2009 Academic Article GET IT
Times cited: 28
varDB: common ground for a shifting landscape. Trends in parasitology. 2009 Article GET IT
Times cited: 3
Genetics of antigenic variation in Plasmodium falciparum. Current genetics. 2009 Information Resource GET IT
Times cited: 49
An upstream open reading frame controls translation of var2csa, a gene implicated in placental malaria. PLoS pathogens. 2009 Academic Article GET IT
Times cited: 66
Chromatin associated sense and antisense noncoding RNAs are transcribed from the var gene family of virulence genes of the malaria parasite Plasmodium falciparum. RNA (New York, N.Y.). 2008 Academic Article GET IT
Times cited: 103
Plasmodium gene regulation: far more to factor in. Trends in parasitology. 2008 Information Resource GET IT
Times cited: 21
Active transcription is required for maintenance of epigenetic memory in the malaria parasite Plasmodium falciparum. Journal of molecular biology. 2008 Academic Article GET IT
Times cited: 44
A regulatable transgene expression system for cultured Plasmodium falciparum parasites. Malaria journal. 2008 Academic Article GET IT
Frequent recombination events generate diversity within the multi-copy variant antigen gene families of Plasmodium falciparum. International journal for parasitology. 2008 Academic Article GET IT
Times cited: 50
Plasmodium falciparum regulatory subunit of cAMP-dependent PKA and anion channel conductance. PLoS pathogens. 2008 Academic Article GET IT
Times cited: 69
Nuclear non-coding RNAs are transcribed from the centromeres of Plasmodium falciparum and are associated with centromeric chromatin. The Journal of biological chemistry. 2007 Academic Article GET IT
Times cited: 60
Mechanisms underlying mutually exclusive expression of virulence genes by malaria parasites. EMBO reports. 2007 Academic Article GET IT
Times cited: 104
Epigenetics in Apicomplexa: control of gene expression during cell cycle progression, differentiation and antigenic variation. Current opinion in microbiology. 2007 Information Resource GET IT
Times cited: 63
Variable switching rates of malaria virulence genes are associated with chromosomal position. Molecular microbiology. 2007 Academic Article GET IT
Times cited: 91
Epigenetic memory at malaria virulence genes. Proceedings of the National Academy of Sciences of the United States of America. 2007 Academic Article GET IT
Times cited: 186
Activation, silencing and mutually exclusive expression within the var gene family of Plasmodium falciparum. International journal for parasitology. 2006 Information Resource GET IT
Times cited: 44
Mutually exclusive expression of virulence genes by malaria parasites is regulated independently of antigen production. PLoS pathogens. 2006 Academic Article GET IT
Times cited: 162
Strict pairing of var promoters and introns is required for var gene silencing in the malaria parasite Plasmodium falciparum. The Journal of biological chemistry. 2006 Academic Article GET IT
Times cited: 88
Antigenic variation by protozoan parasites: insights from Babesia bovis. Molecular microbiology. 2006 Article GET IT
Times cited: 16
A silenced Plasmodium falciparum var promoter can be activated in vivo through spontaneous deletion of a silencing element in the intron. Eukaryotic cell. 2005 Academic Article GET IT
Times cited: 47
Variant surface antigens, virulence genes and the pathogenesis of malaria. Trends in parasitology. 2004 Information Resource GET IT
Times cited: 35
Plasmodium falciparum var genes are regulated by two regions with separate promoters, one upstream of the coding region and a second within the intron. The Journal of biological chemistry. 2003 Academic Article GET IT
Times cited: 134
Gene silencing and antigenic variation in malaria parasites. TheScientificWorldJournal. 2001 Information Resource GET IT
Times cited: 4
Malaria. Cooperative silencing elements in var genes. Nature. 2001 Academic Article GET IT
Times cited: 171
Host sequences in Plasmodium falciparum and Plasmodium vivax genomic DNA: horizontal transfer or contamination artifact?. FEBS letters. 2001 Article GET IT
Times cited: 9
Rapid recombination among transfected plasmids, chimeric episome formation and trans gene expression in Plasmodium falciparum. Molecular and biochemical parasitology. 2001 Academic Article GET IT
Times cited: 31
Transformation of malaria parasites by the spontaneous uptake and expression of DNA from human erythrocytes. Nucleic acids research. 2001 Academic Article GET IT
Times cited: 254
Frequent ectopic recombination of virulence factor genes in telomeric chromosome clusters of P. falciparum. Nature. 2000 Academic Article GET IT
Times cited: 389
Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance. Molecular cell. 2000 Academic Article GET IT
Times cited: 1200
Intra-cluster recombination and var transcription switches in the antigenic variation of Plasmodium falciparum. Molecular and biochemical parasitology. 1999 Academic Article GET IT
Times cited: 91
Three isoforms of a hepatocyte nuclear factor-4 transcription factor with tissue- and stage-specific expression in the adult mosquito. The Journal of biological chemistry. 1998 Academic Article GET IT
Times cited: 14
Shared themes of antigenic variation and virulence in bacterial, protozoal, and fungal infections. Microbiology and molecular biology reviews : MMBR. 1997 Information Resource GET IT
Times cited: 206
Indirect control of yolk protein genes by 20-hydroxyecdysone in the fat body of the mosquito, Aedes aegypti. Insect biochemistry and molecular biology. 1995 Academic Article GET IT
Times cited: 69
Cloning and analysis of the locus for mosquito vitellogenic carboxypeptidase. Insect molecular biology. 1993 Academic Article GET IT
Times cited: 24
An extraovarian protein accumulated in mosquito oocytes is a carboxypeptidase activated in embryos. Proceedings of the National Academy of Sciences of the United States of America. 1991 Academic Article GET IT
Times cited: 111

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Research

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Funding awarded

A structured transcriptional switching network that coordinates antigenic variation by malaria parasites awarded by National Institute of Allergy & Infectious Diseases Principal Investigator 2021 - 2026
Mechanisms of Environmental Sensing and Responses by Malaria Parasites awarded by National Institute of Allergy & Infectious Diseases Principal Investigator 2018 - 2024

Role of Translesional Polymerases in Genome Diversification of the Malaria Parasite awarded by National Institute of Allergy & Infectious Diseases Co-Investigator 2023 - 2024
Role of Translesional Polymerases in Genome Diversification of the Malaria Parasite awarded by National Institute of Allergy & Infectious Diseases Co-Investigator 2019 - 2024

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Background

education and training

Ph.D., Michigan State University 1994
B.S., Central Michigan University 1989

Contact

full name

Kirk W Deitsch

primary email

kwd2001@med.cornell.edu

webpage

https://vivo.med.cornell.edu/individual/n12515 (no url provided for link)

VIVO Weill Cornell Medical College

Kirk W Deitsch Professor of Microbiology and Immunology

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

webpage

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

webpage