Methylxanthine-facilitated shock-induced aggression in the rat. Academic Article uri icon

Overview

abstract

  • The methylxanthines caffeine and aminophylline, in daily doses of 100 mg/kg, facilitated shock-induced aggression in the rat. Under the limited parameters of this study, there was no induction of mouse-killing behavior or alteration of jump thresholds. Additional studies showed the optimal dose and time course for the facilitation of shock-induced aggression by caffeine to be 50 mg/kg administered i.p. 4 h prior to testing. Facilitation of a central adrenergic system may be the mechanism of action.

publication date

  • April 11, 1978

Research

keywords

  • Aggression
  • Aminophylline
  • Caffeine
  • Electroshock

Identity

Scopus Document Identifier

  • 0018097696

PubMed ID

  • 418439

Additional Document Info

volume

  • 56

issue

  • 3