REM sleep eye movement activity and CSF concentrations of 5-hydroxyindoleacetic acid in psychiatric patients. Academic Article uri icon

Overview

abstract

  • The relationship between rapid-eye-movement (REM) sleep tonic and phasic activity measures and the pre- and postprobenecid cerebrospinal fluid (CSF) concentrations of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) was examined in a sample of 14 unmedicated psychiatric patients. The average duration of an eye movement burst and the average number of eye movements within a burst were found to be inversely related to the probenecid corrected accumulation of 5-HIAA in the CSF. These results are interpreted as indicating an association between REM burst eye movement activity and serotonin turnover in psychiatric subjects.

publication date

  • January 1, 1983

Research

keywords

  • Depressive Disorder
  • Hydroxyindoleacetic Acid
  • Psychotic Disorders
  • Schizophrenia
  • Sleep, REM

Identity

Scopus Document Identifier

  • 0020702571

PubMed ID

  • 6188182

Additional Document Info

volume

  • 8

issue

  • 1