A membrane antigen (HC1) selectively present on hairy cell leukemia cells, endothelial cells, and epidermal basal cells. Academic Article uri icon

Overview

abstract

  • A monoclonal antibody (alpha HC1) raised against HCL cells reacted specifically with HCL cells and not with other normal or leukemic B cell types. It also reacted with BC and with vascular EC. One case of Kaposi's sarcoma, a tumor thought to derive from EC, was also stained by this antibody. Sinusoidal cells of liver and spleen and EC in the brain did not stain with alpha HC1, but EC from all other tissues and EC in culture were positive. Because the exact normal cell equivalent of the leukemic hairy cell is unknown, similarities in phenotype and function between EC and hairy cells are of particular interest.

publication date

  • June 1, 1984

Research

keywords

  • Antigens, Neoplasm
  • Antigens, Surface
  • Endothelium
  • Epidermis
  • Leukemia, Hairy Cell

Identity

Scopus Document Identifier

  • 0021247944

PubMed ID

  • 6609956

Additional Document Info

volume

  • 132

issue

  • 6