Characterization of a parvovirus strain isolated from human adenovirus type 12.

Overview

A parvovirus strain was isolated from type 12 human adenovirus. The parvovirus multiplied without helper virus in HEp-2 cell cultures, while its multiplication was enhanced by type 12 and type 18 adenoviruses. Haemagglutinating infective virions as well as soluble haemagglutinins were demonstrated by ultracentrifugation and gel filtration. Virus haemagglutination inhibiting antibodies were found in the sera of healthy rats, whereas sera of healthy persons did not contain antibodies. The parvovirus failed to cause illness in laboratory animals (hamster, mouse, guinea pig).